Effect of Annona muricata Leaf Extract Towards the Sertoli Cells on Alloxan-Induced Mice

Gugun, Devi E; Handayani, Supri Irianti; Lisnawati, L.; Tanuarja, Budiana; Nurbaya, Siti; Prasasty, Vivitri Dewi; Sahar, Nurhuda

doi:10.3923/pjbs.2021.1316.1321

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…The mechanism of action linked to ELAM improved sperm count is flavonoids and saponins, which tend to repair tissue proteins and combat ROS formation in the testicular plasma membrane. The study has accordance with the reports of the study (65,66,68,78,79), revealing improved sperm count in testicular insult following Annona muricata extract, but contradict the findings of Oladipo et al (80) indicating significantly lowered levels of total sperm count following Annona muricata bark extracts. However, MET treatment significantly improved total sperm count, which is linked to the decline in oxidative stress and lipid peroxidation, enhancement of 5'-AMP-activated protein kinase activity, and restoration to the expected levels of pituitary-gonadal hormones (28).…”

Section: Discussionsupporting

confidence: 86%

“…Also revealed in the study is the attenuated effects of MET and ELAM in the ameliorative phase as indicated in groups C and D. The attenuated effect of MET is attributed to its ability to combat lipid peroxidation in the testicular membrane and its tissues as well, and the physiological mechanism of action by ELAM revealing a significant increase in active sperm motility and decrease in non-motile sperm levels is attributed to the presence of flavonoids and saponins, which combats redox formation by arsenic trioxide in the testicular tissue and spermatogenic process. Reports showed that Annona muricata improves sperm motility and non-motile sperm in testicular dysfunction caused by toxins, which supports the study's findings (65)(66)(67)(68)(69). However, MET administration showed improvement in sperm motility following testicular dysfunction in infertile studies (70)(71)(72)(73), which is in line with the study's outcome.…”

Section: Discussionsupporting

confidence: 85%

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The impact of Annona muricata and metformin on semen quality and hormonal profile in Arsenic trioxide-induced testicular dysfunction in male Wistar rat

A¹,

C.C²,

K.C³

et al. 2023

Magna Sci. Adv. Res. Rev.

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Male Infertility has been an issue of significant concern affecting an appraised 20-30% of couples worldwide. The study aims to access the hormonal and semen profile following metformin and ethanolic leave extract of Annona muricata (ELAM) on arsenic-induced toxicity in Male Wistar rats. Thirty-male Wistar rats were used in the study, weighing 150-170 grams, and were divided into six groups of five rats each. Group A received 50 mg/kg of arsenic trioxide (As2O3) only. Group B received feed and water ad libitum. Groups C and D received 50mg/kg of As2O3 and were immediately treated with 30 mg/kg of metformin and 500 mg/kg of ELAM. Group E received 500mg/kg of ELAM and treated immediately with As2O3, and group F received 30 mg/kg of metformin and treated immediately with As2O3. Data obtained were subjected to ANOVA followed by post Hoc LSD using SPSS version 25. Semen quality, Testosterone, FSH, LH levels, and gonadal-somatic index were analysed. Values were presented as Mean±SEM and considered significant at p<0.05. The gonadal-somatic index revealed a significant decrease in group D, while groups B, C, E, and F had no significant decrease compared to A. As2O3 treated rats showed impaired sperm motility, morphology, and total sperm count significantly in groups A to B, while groups C, D, E, and F improved sperm motility, morphology, and total sperm count. Testosterone, LH, and FSH showed a significant decline in group A compared to B, except for LH. Groups C, D, E, and F showed a significant increase in testosterone and LH, except group C in FSH. The study concluded that MET and ELAM improved semen quality and hormonal profile, which could be used in the reversing and prevention of male infecundity linked to arsenic trioxide toxicity caused by oxidative stress.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 85%

The impact of Annona muricata and metformin on semen quality and hormonal profile in Arsenic trioxide-induced testicular dysfunction in male Wistar rat

A¹,

C.C²,

K.C³

et al. 2023

Magna Sci. Adv. Res. Rev.

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“…The clinical efficacy is probably due to the capability of Annona muricata and ellagic acid to induce cell-cycle arrest in the G1 phase, DNA reparation and apoptosis [10]. Moreover, Annona muricata seems to also have a protective role in Sertoli cells in the animal model and could be an interesting drug for male fertility [11]. Interesting findings have been reported for ellagic acid too [12].…”

Section: Introductionmentioning

confidence: 99%

The Use of Ellagic Acid and Annona muricata Complex in Male Subjects with Oligospermia and HPV-Related Infections: Results from a Pilot Study

Cai

Tiscione

Puglisi

et al. 2022

Uro

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Background: Human papilloma virus (HPV) has been recognized as one of the most common sexually transmitted infections and has been correlated with poor semen quality and male hypofertility. Ellagic acid and Annona muricate have been considered as fascinating compounds in the chemoprevention of HPV-related lesions of the cervix. Here, we aimed to evaluate the role of ellagic acid and Annona muricata (OASIT-k®) in managing male subjects with oligospermia and HPV-related infections. Methods: From January 2017 to January 2019, all patients attending our center for oligospermia were evaluated for HPV-DNA. All HPV-DNA positive patients underwent orally administered OASIT-k 1 tablet/day for 3 months. After 6 months, all patients underwent spermiogram, HPV-DNA analysis on seminal plasma and urological visit. The main outcome measures were HPV-DNA clearance rate and improvement of semen parameters. Results: Forty-three patients (aged 22–43 years) were enrolled and treated. At the end of the treatment, the clearance of HPV-DNA infections was 62.7% (27/43). Seminal parameters were improved by treatment in terms of the number of spermatozoa (10.6 vs. 15.8) and mobility (27.5% vs. 36.1%). Conclusions: The therapy with OASIT-K was efficient in improving the HPV-DNA clearance and seminal parameters. These promising data emphasize the importance of redirecting the immune responses in viral infections.

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The Role of Ellagic Acid and Annona muricata in the Management of Human Papillomavirus (HPV)-Related Genital Lesions: A Systematic Review

Cai

Rizzo

Liguori

et al. 2023

Uro

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Background: Several reports highlighted the role of nutraceutical compounds in the prevention and management of HPV-related genital lesions both in men and women, with interesting results. Here, we reviewed the effect of ellagic acid and Annona muricata for managing HPV-related genital lesions. Methods: Relevant databases were searched by using methods recommended by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The primary endpoint was the clinical cure, defined as the clinical and/or laboratory and/or histopatologically demonstrated absence of HPV-related lesions at the end of the treatment. Results: We enclosed two retrospective studies, two prospective studies and one randomized controlled trial. In men, ellagic acid and Annona muricata complex improves seminal parameters and HPV-DNA clearance. In women, it has a chemopreventive action in cervical cancer and increases the HPV viral clearance. No clinically significant adverse effects have been reported. Conclusions: In conclusion, the combination of ellagic acid and Annona muricata shows interesting and promising results in terms of HPV viral clearance and HPV related genital lesions. However, more data are necessary to confirm these results.

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Effect of Annona muricata Leaf Extract Towards the Sertoli Cells on Alloxan-Induced Mice

Cited by 3 publications

References 16 publications

The impact of Annona muricata and metformin on semen quality and hormonal profile in Arsenic trioxide-induced testicular dysfunction in male Wistar rat

The impact of Annona muricata and metformin on semen quality and hormonal profile in Arsenic trioxide-induced testicular dysfunction in male Wistar rat

The Use of Ellagic Acid and Annona muricata Complex in Male Subjects with Oligospermia and HPV-Related Infections: Results from a Pilot Study

The Role of Ellagic Acid and Annona muricata in the Management of Human Papillomavirus (HPV)-Related Genital Lesions: A Systematic Review

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