Effect of Anthocyanin-Rich Extract from Black Rice (Oryza sativa L. Japonica) on Chronically Alcohol-Induced Liver Damage in Rats

Abstract

The study evaluated the protective effect of anthocyanin-rich extract from black rice (AEBR) on chronic ethanol-induced biochemical changes in male Wistar rats. Administration of ethanol (3.7 g/kg/day) to Wistar rats for 45 days induced liver damage with a significant increase (P < 0.05) of aspartate transaminase (AST), alanine transaminase (ALT), gamma glutamyl transferase (GGT) in the serum and the hepatic malondialdehyde (MDA) level. In contrast, administration of AEBR (500 mg/kg) along with alcohol significantly (P < 0.01) decreased the activities of liver enzymes (AST, ALT and GGT) in serum, the MDA levels and the concentrations of serum and hepatic triglyceride (TG) and total cholesterol (TCH). Rats treated with AEBR showed a better profile of the antioxidant system with normal glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and glutathione S-transferase (GST) activities. All these results were accompanied by histological observations in liver. The results demonstrate that AEBR has a beneficial effect in reducing the adverse effect of alcohol.

Thai red rice extract provides liver protection in paracetamol-treated mice by restoring the glutathione system

“…Hom-Dang extract effectively normalized the levels of hepatic transaminases GPT and GOT in paracetamol-treated mice by restoring the glutathione system. Our findings support another study where an anthocyanin-rich extract from black rice (O. sativa L. Japonica) had beneficial effects on alcoholinduced liver damage in rats (Hou et al, 2010).…”

Preventive effect of black rice antioxidant extract on oxidative stress induced by ethyl alcohol

“…The body weights in ethanol treated group rats were found to be significantly (P≤0.05) reduced as compared to the control, which is similar to the previous reports (Lieber, 1994;Hou et al, 2010); the reason may be due to malabsorption and food intake loss (Lieber, 1994). The excessive alcohol ingestion disturbs the metabolism of most nutrients in diet resulting in malnutrition (Lieber, 2000).…”

Dietary Anthocyanins: Impact on Colorectal Cancer and Mechanisms of Action

“…There are several studies, in normal cells and tissues, in which it was demonstrated that anthocyanins, probably involving some protein kinases, modulate the activity of some GSHdependent enzymes, thus ameliorating the antioxidant response (Hou et al, 2010;Suda et al, 2008;Veigas et al, 2008). GSSG formed intracellularly is continuously reduced to GSH by the activity of GR.…”