Effect of anti‐embryo immunization on methylcholanthrene‐induced sarcoma growth in BALB/c mice

Parmiani, Giorgio; Lembo, Rosario

doi:10.1002/ijc.2910140416

Cited by 26 publications

(7 citation statements)

References 25 publications

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“…Some explanations for the existence of common TATA appear to be ruled out. The occurrence of tumor antigens shared with fetal or embryonic tissuesthe poorly defined "oncofetal antigens" that are supposedly activated in neoplastic cellsis not the explanation for the common antigens described by Burton and Warner (1978), (see also Parmiani and Lembo, 1974). MuLV antigens are commonly associated with chemically-induced sarcomas in the mouse.…”

Section: Discussionmentioning

confidence: 99%

Generation of crossreacting tumor antigens in ascitic derivatives from murine methylcholanthrene‐induced sarcomas

Law

1984

Intl Journal of Cancer

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Sarcomas induced by the chemical carcinogen 3-methyl-cholanthrene (MC) in pedigreed BALB/c strain mice were studied for the existence and characteristics of tumor-specific antigens that induce protective immune defenses in syngeneic mice (TATA). It was found that each of the neoplasms expressed a unique immunogenicity that was stable and heritable over a period of 125 transfers in vivo. Common or crossreacting TATA were not observed. When converted to an ascitic form, two of these sarcomas, CII-7 and CII-10, were found to be crossreactive, presumably sharing TATA with each other and with the MC-induced sarcoma Meth A. Two other neoplasms converted to the ascitic form, however, retained their unique TATA. Although the precise nature of unique and crossreacting TATA is not known, it is hoped that recent investigations in the purification of TATA of chemically induced neoplasms will shed light on the mechanisms responsible for the diversity of tumor-specific antigens.

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Section: Discussionmentioning

confidence: 99%

Generation of crossreacting tumor antigens in ascitic derivatives from murine methylcholanthrene‐induced sarcomas

Law

1984

Intl Journal of Cancer

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“…In contrast to this, several workers, using SV40-induced tumours (Coggin, Ambrose and Anderson, 1970) and Rauscher-leukaemia-virus-induced tumours (Hanna, Tennant and Coggin, 1971) have suggested that foetal immunization can confer tumour immunity. Perhaps even more striking are the examples where foetal immunization has been shown to enhance the growth of tumours expressing embryo-associated antigens (Castro et al, 1973;Parmiani and Lembo, 1974). In addition, a recent communication from this laboratory showed that * The author regrets that no reprints of this article will be available.…”

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confidence: 99%

Response of tumour-related and normal lymphocytes to antigens on fibroblasts from embryos of varying age

Gorczynski¹

1978

Br J Cancer

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Summary.-The in vitro cytotoxic immune response of spleen lymphocytes from primiparous and tumour-related mice to embryonic cells from embryos of varying age and tumour cells has been investigated. The results indicate that lymphocytes from both primiparous and tumour-related (i.e., tumour-bearing or tumour-excised) animals give a response which is greater than that from cells from control mice ("virgin cells"). Moreover, in this putative anamnestic response the immune cells detect antigenic differences in the cell populations of embryos of varying age, which are not as readily demonstrable when cytotoxicity is derived from virgin cells. As a further indication of the in vivo priming to embryo-associated antigens, the data show that the precursors of cytotoxic cells apparently undergo a blastogenic response in the presence of embryo antigen, and revert to small quiescent cells when antigen is removed, in a way entirely analogous to that described for reactivity of mixed leucocyte cultures to antigens of the major histocompatibility complex. Finally, it seems that in animals immediately after removal of embryonic antigen (and to a lesser degree in virgin or late-embryo-immune mice) there exists a suppressor cell population which inhibits an anti -embryo cytotoxic response far more than an antiallograft response.

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“…In vitro cytotoxicity of lymphoid cells from embryo-immunized rats Spleen cells and LNC taken from embryoma-excised rats and rats immunized with 3-5 weekly inoculations of 14-15-day-old rat embryo cells were tested for in vitro cytotoxicity towards tumour, embryo and normal rat target cells (Table IV) (Baldwin et al, 1973;Rees, Bray, Robins and Baldwin, 1975 Le Mevel and Wells, 1973;Parmiani and Lembo, 1974;Bendick, Borenfreund and Stonehill, 1973;Baldwin et al, 1973). This may in part reflect differences between the tumour systems studied as well as differences in the embryonic tissue used, or its method of preparation.…”

Section: Resultsmentioning

confidence: 99%

Tumour rejection in rats sensitized to embryonic tissue. I. Rejection of tumour cells implanted s.c. and detection of cytotoxic lymphoid cells

Shah¹,

Rees²,

Baldwin³

1976

Br J Cancer

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Summary.-Wistar rats were sensitized to rat embryonic tissue by immunization with irradiated (5000rad) rat embryo cells (2 x 106 s.c. + 1 x 106 i.p.) derived from embryos aged 14-15 days, or by implantation of irradiated (5000 rad) tissue grafts from these embryos. Three to five immunizations were given at weekly intervals, and the rats were then challenged subcutaneously 7-10 days after the final inoculum with minimal tumour-producing tumour cell doses. Immunization with irradiated rat embryo cells failed to influence the growth and development of tumour cells prepared from hepatoma D23 and D30, sarcoma Mc57, mammary carcinoma AAF57 or cells prepared from spontaneously arising mammary carcinomata Sp4 and Spl5. Using adoptive transfer techniques, lymphoid cells from embryo-sensitized rats, when used in a 3000 :1 ratio (lymphoid cells: tumour cells), were shown effectively to retard the growth of hepatoma D23 in 3 out of 7 experiments performed. Similar adoptive transfer procedures proved ineffective in preventing the growth of mammary carcinoma AAF57. Using in vitro cytotoxicity tests, lymph node cells and spleen cells from embryo-immunized rats were shown to be cytotoxic for several rat tumour cell targets: hepatoma D23 (7/10 tests), sarcoma Mc7 (8/12 tests), mammary carcinoma AAF57 (2/2 tests) and Sp4 (3/4 tests), and for 14-15-day-old rat embryo cells (5/10 tests). In comparative tests lymphoid cells were relatively non-cytotoxic for 20-day-old rat embryo cells (1/6 tests) or cells prepared from adult rat lung or kidney (1/10 tests). The role of embryonic antigen(s) in tumour rejection is discussed.

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Effect of anti‐embryo immunization on methylcholanthrene‐induced sarcoma growth in BALB/c mice

Cited by 26 publications

References 25 publications

Generation of crossreacting tumor antigens in ascitic derivatives from murine methylcholanthrene‐induced sarcomas

Generation of crossreacting tumor antigens in ascitic derivatives from murine methylcholanthrene‐induced sarcomas

Response of tumour-related and normal lymphocytes to antigens on fibroblasts from embryos of varying age

Tumour rejection in rats sensitized to embryonic tissue. I. Rejection of tumour cells implanted s.c. and detection of cytotoxic lymphoid cells

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