Effect of Anti-inflammatory Agent No.6 for injection on the cAMP content of rat peritoneal macrophages

Chen, N; Feng, Xilian

doi:10.1007/bf02888164

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…In the abovementioned studies, bicycles as important road users were considered, but still in a limited way, with factors such as speed and relative distance, there was no in-depth analysis of the cycling behavior that could interfere with vehicles. Compared to the vehicle, which drives along the lane with a relatively simple behavior, bicycles exhibit the following two behavioral characteristics: (1) complex behavioral patterns [2]: when cyclists ride on a road segment, they tend to adopt a variety of behaviors, mainly lateral (turning the handlebars) and longitudinal (braking or accelerating) [32], and these actions tend to have diferent characteristics and cause diferent interferences with vehicles [33]. (2) High behavioral uncertainty [3]: bicycles are highly susceptible to the changing behavior, and cyclists may behave diferently in diferent scenarios, which can pose a great challenge for vehicles to cope with them [1,4], especially AVs.…”

Section: Literature Reviewmentioning

confidence: 99%

Assessing the Complexity of Potential Bicycle Interference on Vehicles on Urban Road Segments

Wang

2023

Journal of Advanced Transportation

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Interacting with bicycles on urban road segments is complex for vehicles, due to the diverse and flexible cycling behavior that can cause interferences. Studies show that driving mixed with bicycles is also a great challenge for autonomous vehicles (AVs), and it is necessary to consider the interference of bicycles when selecting public roads for testing. However, existing road evaluation methods mostly focus on autonomous driving functions and accident analysis, although bicycles have been considered, often with insufficient consideration of their interference. This study analyzes two types of cycling behavior that could interfere with vehicles, including lateral (turning handlebars) and longitudinal (braking or accelerating) behavior, with each occurrence of such behavior considered as one potential lateral or longitudinal interference. From the perspective of cycling behavior, a framework is proposed to assess the complexity of potential bicycle interference on vehicles on road segments. A higher frequency of both potential lateral and longitudinal interference represents a higher complexity of potential interference. A naturalistic field experiment was conducted to collect the potential lateral and longitudinal interference frequency and the environmental parameters of road segments. The quantile regression model was applied to analyze the environmental factors influencing different interference frequencies separately and further establish the assessing model of the potential bicycle interference complexity, and the usability of the model has been demonstrated with a case study. Results show that the potential interference complexity varies across road segments, with some factors leading to more frequent potential lateral and longitudinal interference but with varying degrees of impact (such as the separation between bicycles and vehicles), while some only affect the lateral interference frequency (such as the on-street parking condition). The proposed framework can help autonomous driving companies or evaluation agencies to select appropriate testing roads, thus promoting the development of autonomous driving.

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Section: Literature Reviewmentioning

confidence: 99%

Assessing the Complexity of Potential Bicycle Interference on Vehicles on Urban Road Segments

Wang

2023

Journal of Advanced Transportation

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Stress-induced epinephrine promotes epithelial-to-mesenchymal transition and stemness of CRC through the CEBPB/TRIM2/P53 axis

et al. 2022

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Background Previous studies have indicated that chronic emotional stressors likely participate in the occurrence of cancers. However, direct evidence connecting stress and colorectal cancer development remains almost completely unexplored. Methods Chronic stress mouse model was used to investigate the influence of stress on tumorigenesis. Several major agonists and antagonists of adrenergic receptors were applied to investigate the effects of β-adrenergic signaling on the development of CRC. Chromatin immunoprecipitation assays (CHIP) were used to investigate the binding of p53 and CEBPB to TRIM2 promoter. Mammosphere cultures, Cell Counting Kit-8 (CCK-8) assay, colony-formation assay, scratch wound healing assays, qPCR, immunofluorescence, coimmunoprecipitation and western blotting were used to explore the effect of stress-induced epinephrine on the CEBPB/TRIM2/P53 axis and the progress of CRC cells. Results In this study, we found that stress-induced epinephrine (EPI) promotes the proliferation, metastasis and CSC generation of CRC primarily through the β2-adrenergic receptor. Furthermore, our studies also confirmed that chronic stress decreased the stability of p53 protein by promoting p53 ubiquitination. Results of transcriptome sequencing indicated that TRIM2 was overexpressed in cells treated with EPI. Further studies indicated that TRIM2 could regulate the stability of p53 protein by promoting p53 ubiquitination. Finally, we further proved that CEBPB was regulated by EPI and acts as the upstream transcription factor of TRIM2. Conclusions Our studies proved that stress-induced EPI promotes the development and stemness of CRC through the CEBPB/TRIM2/P53 axis.

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Effect of Anti-inflammatory Agent No.6 for injection on the cAMP content of rat peritoneal macrophages

Cited by 2 publications

References 2 publications

Assessing the Complexity of Potential Bicycle Interference on Vehicles on Urban Road Segments

Assessing the Complexity of Potential Bicycle Interference on Vehicles on Urban Road Segments

Stress-induced epinephrine promotes epithelial-to-mesenchymal transition and stemness of CRC through the CEBPB/TRIM2/P53 axis

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