1994
DOI: 10.1016/s0168-8278(05)80393-9
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Effect of antiandrogen treatment on chemical hepatocarcinogenesis in rats

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Cited by 20 publications
(11 citation statements)
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“…Nevertheless, clinical trials using various anti-androgens in the attempt to treat HCC have inconsistent conclusions (Groupe d'etude et de traitement du carcinome, H., 2004, Matsuura et al, 1994, Chao et al, 1996). Several hypotheses have been proposed to elucidate this riddle, such as the fact that most of the anti-androgen therapies were developed to reduce/antagonize androgens from binding to AR, but not to target AR itself.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Nevertheless, clinical trials using various anti-androgens in the attempt to treat HCC have inconsistent conclusions (Groupe d'etude et de traitement du carcinome, H., 2004, Matsuura et al, 1994, Chao et al, 1996). Several hypotheses have been proposed to elucidate this riddle, such as the fact that most of the anti-androgen therapies were developed to reduce/antagonize androgens from binding to AR, but not to target AR itself.…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies revealed a male predominance in HCC, which suggested that androgen/AR signals may promote hepatocarcinogenesis (Yeh and Chen, 2010). However, the results from several clinical trials using various anti-androgens to treat HCC remain controversial (Groupe d'etude et de traitement du carcinome, H., 2004, Matsuura et al, 1994, Chao et al, 1996). Interestingly, Ma et al revealed that AR might suppress advanced-stage HCC metastasis using liver-specific deletion of AR (L-ARKO) mice model and in vitro HCC cell lines, and over-expressing AR with Sorafenib treatment could better suppress the HCC progression at late stages (Ma et al, 2012).…”
Section: Introductionmentioning
confidence: 99%
“…HCC occurs much more frequently in men than in women, with a male to female ratio ranging from 2:1 to 11:1 (3). Both animal and human studies support the importance of androgen signaling in determining the male preference of HCC (4)(5)(6)(7)(8)(9)(10)(11)(12)(13). It was also noted that the expression and activation of androgen receptor (AR) is increased in the tumor tissues as well as in the surrounding nontumorous liver tissue of patients with HCC (14)(15)(16).…”
mentioning
confidence: 87%
“…Animal studies demonstrated that the expression of both AR and ER increases during preneoplastic stages and that progression towards cancer development can suppress ER and maintain AR expression levels [94,100] . Interestingly, anti-androgen treatment has been shown to reduce AR levels in liver as well as the size and number of tumors in male Spargue Dawley rat model of hepatocarcinogenesis [101] . It has been shown that inhibition of AR positive HCC with anti-androgen cypertone acetate in male mice involves cell cycle arrest and to some extent induction of apoptosis due to increased synthesis of transforming growth factor-β 1 (TGF-β1) [102] .…”
Section: Androgen Receptor Studiesmentioning
confidence: 99%