Effect of antibiotics and NSAIDs on cyclooxygenase-2 in the enamel mineralization

Muñoz, Clara; Silva, Amparo Pérez; Solano, Francisco; Castells, María Teresa; Vicente, Ascensión; Ruiz, Antonio José Ortiz

doi:10.1038/s41598-018-22607-z

Cited by 16 publications

(14 citation statements)

References 32 publications

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“…Childhood infections can disturb ameloblasts during the late secretory or early maturation stage either directly or indirectly through malnutrition, an increase in temperature, pH shifts, hypoxia, or hypocalcemia. 35 – 39 Children with a breastfeeding history of >18 months presented with 3.73 times greater MIH risk. Prolonged breastfeeding may increase exposure to dioxins, which are widely spread environmental pollutants.…”

Section: Discussionmentioning

confidence: 99%

Frequency of molar incisor hypomineralization and associated factors among children with special health care needs

et al. 2021

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BACKGROUND: Molar incisor hypomineralization (MIH) is a frequently encountered oral condition that varies from mild opacities to posteruptive enamel breakdown. No previous published studies have investigated the frequency of MIH and associated risk factors among children with special health care needs (CSHCN) to our awareness. OBJECTIVES: Assess the frequency of MIH and associated risk factors among CSHCN. DESIGN: Cross-sectional. SETTING: Schools in provincial city of Saudi Arabia. PATIENTS AND METHODS: The study was conducted among 400 (180 boys and 220 girls) special needs children. Diagnosis of MIH was according to the European Academy of Paediatric Dentistry criteria. MAIN OUTCOME MEASURE: Result of logistic regression analysis that assessed the association between MIH prevalence and associated prenatal, perinatal, and postnatal factors. SAMPLE SIZE: 400 (180 boys and 220 girls) special needs children. RESULTS: Among 400 CSHCN, 98 (24.5%) presented with MIH. Children with multiple disabilities had a 3.89 times greater risk of MIH (95% CI: 1.91–6.19, P =.002). Children with positive prenatal factors had an adjusted odds ratio (aOR) of 2.31 times for MIH (95% CI: 1.22–4.73, P =.012). Children with a childhood infection history had an aOR of 2.43 times for MIH (95% CI: 1.31–5.85, P =.014). Children with a breastfeeding history >18 months had an aOR of 3.73 for MIH (95% CI: 1.62–8.60, P =.002). Permanent maxillary first molars were the most frequently affected teeth, and demarcated opacity was the most frequent MIH type. CONCLUSION: MIH should be recognized as one of the prevalent oral health problems among CSHCN to prevent tooth mortality. LIMITATIONS: A cross-sectional study cannot establish a causal relationship. CONFLICTS OF INTEREST: None.

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Section: Discussionmentioning

confidence: 99%

Frequency of molar incisor hypomineralization and associated factors among children with special health care needs

et al. 2021

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“…A previous study demonstrated that COX-2 was involved in enamel maturation and the inhibition of COX-2 could inhibit the formation of tooth enamel. 28 PGE2 also affected the maturation of mineralization. 29 The inhibitory effect of meloxicam on COX-2 and the regulation of PGE2 may be related to the maturation of odontogenic mineralization, which requires further investigation.…”

Section: Discussionmentioning

confidence: 96%

The effect of topical application of meloxicam on inflamed dental pulp

Wang

Dong

2021

Journal of Dental Sciences

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Background/purpose Effective regulation of the inflammatory process is essential for pulp repair and regeneration. Meloxicam has anti-inflammatory activity in systemic administration. The purpose of this study is to observe effects of topically applied meloxicam on inflamed pulp and to explore its potential value in the treatment of pulpitis. Materials and methods The coronal pulp tissues of rat molars were stimulated with 10 mg/mL lipopolysaccharide (LPS group) and then treated with 500 μmol/L meloxicam (meloxicam group). The untreated pulp tissues were used as the control group. After 3 h of incubation in vitro , the gene expression of interleukin-6 ( IL-6 ) and tumour necrosis factor-α ( TNF-α ) in each group was detected by real-time RT-PCR. The pulp tissues of each group were randomly subcutaneously implanted into nude mice, and 500 μmol/L meloxicam was injected into the subcutaneous pocket of the meloxicam group. Haematoxylin eosin staining, Masson staining and immunohistochemical staining were performed on samples after 3 days and 4 weeks retrieval, respectively. Results Compared with the LPS group, the mRNA expression levels of TNF-α and IL-6 of the meloxicam group were significantly reduced in vitro . The inflammatory response and cyclooxygenase-2 expression of the meloxicam group were decreased, and osteodentin-like tissue was generated in the pulp cross section of the meloxicam group in vivo . Conclusion The topical application of meloxicam inhibits the inflammatory response of inflamed pulp and further promotes the formation of osteodentin-like tissues but fails to induce the formation of the pulp–dentin complex. Topically applied meloxicam has the potential to regulate pulp inflammation.

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“…Ameloblasts are able to deposit the enamel matrix, but due to the low oxygen demand they have difficulties reabsorbing the proteins from the matrix, compromising the calcium phosphate deposit. This lack of oxygen can occur due to complications in childbirth, respiratory problems, renal problems that characterize an inadequate supply of calcium phosphate, diarrhea, malnutrition, and frequent childhood diseases with a history of high fever 6,10,11,14,16 .…”

Section: Discussionmentioning

confidence: 99%

“…According to some studies, patients with respiratory diseases such as asthma, bronchitis and allergic rhinitis are more likely to develop enamel defects 1,8,9 . Enamel matrix is affected due to low oxygen demand, inhibiting the action of proteolytic enzymes compromising the formation of hydroxyapatite crystal, resulting in hypo mineralized enamel 1,11 .…”

Section: Introductionmentioning

confidence: 99%

Associating the Presence of Structural Defects in Dental Enamel with Children's Health History

et al. 2021

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The enamel defects, hypoplasia and hypo mineralization, are classified as dental anomalies of structure, being frequently found in deciduous and permanent dentitions, since the permanent teeth and second deciduous molars finish their total mineralization after the age of three. The aim of the present study was to identify the presence of hypo mineralization and/or enamel hypoplasia and to associate it with respiratory problems in infant patients. Of the 90 patients evaluated, it was found that 23 male children (57.5%) and 22 female children (44%) had defects in the structure of tooth enamel. Most children were born by cesarean operation (64.4%), with no complications during birth (90.0%), 12.2% of children had dental anomalies (agenesis, ectopic canine, ankylosis, fusion, conoid tooth, and macrodontia, only 7 children showed an association between dental anomalies and enamel defects. Regarding respiratory problems that occurred up to 3 years of age, 38.9% had an episode of asthma, bronchitis, sinusitis, rhinitis, or pneumonia, and 55% had similar results at the current age. There was a positive association (Chi-square tests) between the presence of changes in the structure of tooth enamel and the presence of respiratory problems up to 3 years of age (p <0.001). It is concluded, therefore, that the presence of respiratory problems in early childhood, can interfere in amelogenesis, providing disturbances for the formation of normal enamel, causing defects or irregularities in the surface of the dental enamel, such as hypoplasias and hypo mineralization. Keywords: Dental Enamel Hypoplasia. Dental Enamel. Tooth Abnormalities. ResumoOs defeitos de esmalte, hipoplasia e hipomineralização, são classificados como anomalias dentárias de estrutura, sendo encontrados com frequência nas dentições decídua e permanente, já que os dentes permanentes e segundos molares decíduos finalizam sua total mineralização após os três anos de idade. O objetivo do presente estudo foi identificar a presença de hipomineralização e/ou hipoplasia de esmalte, e associá-la com problemas respiratórios no paciente infantil. Dos 90 pacientes avaliados, constatou-se que 23 crianças do gênero masculino (57,5%) e 22 do gênero feminino (44%) apresentaram defeitos na estrutura do esmalte dentário. A maioria das crianças nasceu de parto cesária (64,4%), sem complicação no parto (90,0%), 12,2% das crianças apresentaram anomalias dentárias (agenesia, canino ectópico, anquilose, fusão, dente conóide e macrodontia), somente 7 crianças apresentaram associação entre anomalias dentárias e defeitos de esmalte. Em relação à problemas respiratórios ocorrido até aos 3 anos de idade 38,9% apresentaram algum episódio de asma, bronquite, sinusite, rinite ou pneumonia e 55% apresentaram resultados semelhantes na idade atual. Houve associação positiva (Testes Qui Quadrado) entre a presença de alterações na estrutura do esmalte dentário e presença de problemas respiratórios até os 3 anos de idade (p<0,001). Conclui-se, portanto, que a presença de problemas respiratórios na primeira infância, podem interferir na amelogênese, proporcionando distúrbios para formação do esmalte normal, causando defeitos ou irregularidades na superfície do esmalte dentário, como hipoplasias e hipomineralizações. Palavras-chave: Hipoplasia do Esmalte Dentário. Esmalte Dentário. Anormalidades Dentárias.

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Effect of antibiotics and NSAIDs on cyclooxygenase-2 in the enamel mineralization

Cited by 16 publications

References 32 publications

Frequency of molar incisor hypomineralization and associated factors among children with special health care needs

Frequency of molar incisor hypomineralization and associated factors among children with special health care needs

The effect of topical application of meloxicam on inflamed dental pulp

Associating the Presence of Structural Defects in Dental Enamel with Children's Health History

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