Effect of antifreeze proteins on frozen primary prostatic adenocarcinoma cells

Koushafar, Homayoon; Rubinsky, Boris

doi:10.1016/s0090-4295(96)00572-9

Cited by 58 publications

(24 citation statements)

References 10 publications

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“…Using prostate cancer cells in vitro, Koushafar and Rubinsky have shown that the destructive effects of freezing are enhanced by antifreeze proteins [109]. The intracellular ice crystals, which form at warm freezing temperatures, cause mechanical damage to the cells.…”

Section: Adjunctive Therapymentioning

confidence: 99%

Experimental cryosurgery investigations in vivo

2009

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Cryosurgery is the use of freezing temperatures to elicit an ablative response in a targeted tissue. This review provides a global overview of experimentation in vivo which has been the basis of advancement of this widely applied therapeutic option. The cellular and tissue-related events that underlie the mechanisms of destruction, including direct cell injury (cryolysis), vascular stasis, apoptosis and necrosis, are described and are related to the optimal methods of technique of freezing to achieve efficacious therapy. In vivo experiments with major organs, including wound healing, the putative immunological response following thawing, and the use of cryoadjunctive strategies to enhance cancer cell sensitivity to freezing, are described.

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Section: Adjunctive Therapymentioning

confidence: 99%

Experimental cryosurgery investigations in vivo

2009

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“…tissues, red blood cells and sperms) have shown promising and beneficial effects. It was reported that the survival of oocytes, spermatozoa, and adenocarcinoma cells is raised at the presence of AFPs (Arav, Rubinsky, Fletcher, & Seren, 1993;Koushafar & Rubinsky, 1997;Payne, Oliver, & Upreti, 1996). Adding AFPs also increases the quality of ice cream and ice slurries (Grandum, Yabe, Tanaka, Takemura, & Nakagomi, 1997;Payne & Young, 1995;Warren, Mueller, & McKown, 1992).…”

Section: Introductionmentioning

confidence: 99%

Effect of carrot (Daucus carota) antifreeze proteins on the fermentation capacity of frozen dough

Zhang

Wang

2007

Food Research International

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“…Type I AFP-driven intracellular ice crystals destroyed human primary prostatic adenocarcinoma cells [106,152], and subcutaneous tumors of mice were destroyed to a much better extent than in the case of treatment without type I AFP injection prior to freezing [153,154]. …”

Section: Application Studiesmentioning

confidence: 99%

Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology

et al. 2013

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Antifreeze proteins (AFPs) and glycoproteins (AFGPs), collectively called AF(G)Ps, constitute a diverse class of proteins found in various Arctic and Antarctic fish, as well as in amphibians, plants, and insects. These compounds possess the ability to inhibit the formation of ice and are therefore essential to the survival of many marine teleost fishes that routinely encounter sub-zero temperatures. Owing to this property, AF(G)Ps have potential applications in many areas such as storage of cells or tissues at low temperature, ice slurries for refrigeration systems, and food storage. In contrast to AFGPs, which are composed of repeated tripeptide units (Ala-Ala-Thr)n with minor sequence variations, AFPs possess very different primary, secondary, and tertiary structures. The isolation and purification of AFGPs is laborious, costly, and often results in mixtures, making characterization difficult. Recent structural investigations into the mechanism by which linear and cyclic AFGPs inhibit ice crystallization have led to significant progress toward the synthesis and assessment of several synthetic mimics of AFGPs. This review article will summarize synthetic AFGP mimics as well as current challenges in designing compounds capable of mimicking AFGPs. It will also cover our recent efforts in exploring whether peptoid mimics can serve as structural and functional mimics of native AFGPs.

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Effect of antifreeze proteins on frozen primary prostatic adenocarcinoma cells

Cited by 58 publications

References 10 publications

Experimental cryosurgery investigations in vivo

Experimental cryosurgery investigations in vivo

Effect of carrot (Daucus carota) antifreeze proteins on the fermentation capacity of frozen dough

Antifreeze Peptides and Glycopeptides, and Their Derivatives: Potential Uses in Biotechnology

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