Effect of Antihypertensive Treatment on Lipids and Fibrinogen: Greek Multicentre Study of Cilazapril

Abstract

The effect of cilazapril (CLZ) treatment on serum lipids and fibrinogen was studied in 114 hypertensive patients for 18 weeks. Blood pressure, heart rate, lipid profile and fibrinogen were measured before and at the end of the study in all patients. Satisfactory blood pressure control was seen in 68% of the patients (group A) after 4 weeks of treatment with 5 mg CLZ monotherapy, while a single dose of chlorthalidone, 25 mg daily, was added to the therapeutic regimen of the remaining 32% of patients (group B) to achieve blood pressure control. We conclude that CLZ has a slight beneficial effect on the lipid profile and a significantly beneficial effect on fibrinogen, but its combination with a diuretic reverses this beneficial effect.

Effect of Antihypertensive Treatment on PlasmaFibrinogen and Serum HDL Levelsin Patients with Essential Hypertension

“…In contrast, Koenig et al (46) showed in 28 mild to moderate hypertensives that Fib plasma levels were significantly elevated when their treatment switched from felodipine to hydrochlorothiazide. Chlorthalidone (25 mg/day) also reversed the beneficial effect of cilazapril (5 mg/day) monotherapy on Fib concentration (39). The effect of β-blockers on plasma Fib concentration is controversial.…”

Effect ofMelothria maderaspatanaLeaf-Tea Consumption on Blood Pressure, Lipid Profile, Anthropometry, Fibrinogen, Bilirubin, and Albumin Levels in Patients with Hypertension

“…Perhaps augmented synthesis of fibrinogen may be due to increased utilization during mechanical injury caused by hypertension. Some experimental evidence suggests that administering pharmacologic agents to lower blood pressure can reduce fibrinogen levels or blood viscosity; 39,40 this also implies that high blood pressure may raise hemorrheologic parameters, rather than vice versa. Plasma fibrinogen concentration depends on the rate at which it is secreted into the blood from the liver where it is synthesized and on the rate of its elimination from the blood.…”