2020
DOI: 10.3934/publichealth.2020009
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Effect of antioxidant supplements on sperm parameters in infertile male smokers: a single-blinded clinical trial

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Cited by 10 publications
(14 citation statements)
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“…In a recent single-blinded trial, Sadaghiani et al enrolled 50 oligospermic and asthenospermic subjects who were also active smokers to investigate the effect of antioxidant supplementation (30 mg CoQ10, 8 mg zinc, 100 mg vitamin C, 12 mg vitamin E, 400 µg folic acid once a day and 200 mg selenium every other day) on semen parameters. After 3 months, the mean volume of sperm rose from 3.48 ± 1.44 to 3.71 ± 1.42 mL (p = 0.032), the total sperm count rose from 21.76 ± 23.02 to 23.22 ± 23.28 × 10 6 (p = 0.001), total sperm motility changed from 27.22 ± 13.69 to 31.85 ± 5.82% (p = 0.001); progressive motility increased from 9.82 ± 9.10 to 11.57 ± 10.18% (p = 0.001), and normal sperm morphology changed from 23.22 ± 23.28 to 33.60 ± 20.01% (p = 0.003) [30].…”
Section: Compound Combinations and Male Infertilitymentioning
confidence: 99%
“…In a recent single-blinded trial, Sadaghiani et al enrolled 50 oligospermic and asthenospermic subjects who were also active smokers to investigate the effect of antioxidant supplementation (30 mg CoQ10, 8 mg zinc, 100 mg vitamin C, 12 mg vitamin E, 400 µg folic acid once a day and 200 mg selenium every other day) on semen parameters. After 3 months, the mean volume of sperm rose from 3.48 ± 1.44 to 3.71 ± 1.42 mL (p = 0.032), the total sperm count rose from 21.76 ± 23.02 to 23.22 ± 23.28 × 10 6 (p = 0.001), total sperm motility changed from 27.22 ± 13.69 to 31.85 ± 5.82% (p = 0.001); progressive motility increased from 9.82 ± 9.10 to 11.57 ± 10.18% (p = 0.001), and normal sperm morphology changed from 23.22 ± 23.28 to 33.60 ± 20.01% (p = 0.003) [30].…”
Section: Compound Combinations and Male Infertilitymentioning
confidence: 99%
“…In a study conducted on 15 infertile patients with oligozoospermia and/or asthenozoospermia, Terai et al [ 142 ] reported that the combined administration of 1000 mg of AA, 750.1 mg of L-carnitine, 30 mg of zinc, 16.05 mg of astaxanthin, 90.26 mg of coenzyme Q 10 , 60.1 µg of vitamin B 12 and 150 mg of vitamin E three times a day for 12 weeks, significantly improved only total motile sperm count, with no effects on the other semen parameters. In a single-blinded clinical trial, Sadaghiani et al [ 143 ] reported that the daily administration for three consecutive months of 100 mg of AA, 30 mg of coenzyme Q 10 , 8 mg of zinc, 12 mg of vitamin E and 400 μg of folic acid, combined with that of 200 mg of selenium every other day, to 50 infertile oligozoospermic and asthenozoospermic male smokers, beneficially affected various morpho-functional semen parameters (concentration, pH, volume, total motility, morphology, count and progressive motility). A substantially different scenario was depicted by Steiner et al [ 144 ], who conducted a randomized controlled trial on 174 infertile males (categorized into oligozoospermic, asthenozoospermic, teratozoospermic and DNA fragmented patients), analyzed for sperm analysis anomalies and clinical outcome measures of fertility (pregnancy and live birth rates).…”
Section: Antioxidant-based Therapies In the Treatment Of Male Infementioning
confidence: 99%
“…As previously underlined, most of the studies focused their attention on the effectiveness of different vitamin E-containing antioxidant mixtures [ 138 , 139 , 140 , 141 , 142 , 143 , 144 , 158 ], thus rendering it difficult (if not impossible) to separate the effects of tocopherols from those of the other administered antioxidants. In this context, in a prospective, open-labeled, nonrandomized study conducted by Lipovac et al [ 175 ], 299 subfertile males with at least one recent pathological semen analysis were treated for 3 months either with 500 mg L-carnitine/twice a day ( n = 156) or with the combination of 440 mg L-carnitine + 250 mg L-arginine + 40 mg zinc +120 mg vitamin E + 80 mg GSH + 60 μg selenium + 15 mg coenzyme Q 10 + 800 μg folic acid/once a day ( n = 143).…”
Section: Antioxidant-based Therapies In the Treatment Of Male Infementioning
confidence: 99%
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“…Hasil yang didapatkan setelah pemberian suplemen antioksidan (30 mg koenzim Q10, 8 mg seng, 100 mg vitamin C, 12 mg vitamin E, dan 400 mg asam folat sekali sehari selama 3 bulan dan 200 mg selenium setiap hari setelah makan siang), yaitu terjadi peningkatan spermatozoa setelah pemberian intervensi. 19 Penelitian ini dalam bentuk literature review memiliki kelebihan dan kekurangan. Kelebihannya adalah topik penelitian yang terkait vitamin C. Vitamin C atau sumber makanan yang mengandung vitamin C merupakan vitamin yang sudah dikenal luas di kalangan masyarakat dan sangat mudah ditemukan.…”
Section: Bahasanunclassified