Effect of Antioxidant Therapy on Oxidative Stress in Vivo

Pasini, Anna Maria Fratta; Cominacini, Luciano

doi:10.3390/antiox10030344

Cited by 4 publications

(2 citation statements)

References 31 publications

(31 reference statements)

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“…The phytochemical compounds identified in the studied walnut leaf extracts have a series of biological activities. These were established and published in several studies, listed in the Supplementary Material (Table S1) [6,34,39,[47][48][49][50][51][52][53][54][55][56][57][58][59][60]. The main compounds identified within this study belong to the following phytochemical classes: phenolic acids, flavonoids, flavones, flavanones, flavonones, flavanols, vitamins, tereponoids, steroids, anthocyanidins, and other compounds.…”

Section: Compoundmentioning

confidence: 96%

Superior Valorisation of Juglans regia L. Leaves of Different Maturity through the Isolation of Bioactive Compounds

Tociu,

Manolache,

Bălănucă

et al. 2023

Molecules

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Extracts rich in bioactive compounds from natural sources have received great interest due to their great impact on human health. The aim of this research is focused on the obtaining and characterization of several extracts from Juglans regia L. leaves in four different maturity phases: young green leaves (YGL), green leaves (GL), mature green leaves (MGL), and yellow leaves (YL), using different solvents: ethanol (e), water (w), or water:ethanol (1:1 (v/v)—m) by employing several methods: magnetic stirring (MS), ultrasound-assisted (UA), as well as maceration (M). The obtained extracts were quantitatively evaluated through spectrophotometric methods: Total Polyphenol Content (TPC-Folin–Ciocalteu assay) and Total Antioxidant Capacity (TEAC assay). Phytochemical screening by means of Fourier-Transform Ion–Cyclotron-Resonance High-Resolution Mass Spectrometry (FT-ICR-MS) indicated the presence of 40 compounds belonging to different phytochemical classes: phenolic acids, flavonoids, flavones, flavanones, flavonones, flavanols, vitamins, tereponoid, steroid, anthocyanidin, and other compounds. Based on TPC and TEAC assays, the water-ethanol mixture was found to be the proper extraction solvent, with the best results being obtained for YL plant material: 146.29 mg GAE/g DM (TPC) and 11.67 mM TE/g DM (TEAC). This type of extract may be used in various domains, such as the cosmetics industry, the biomedical field, and/or the design of functional foods, relying on their phytochemical composition.

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Section: Compoundmentioning

confidence: 96%

Superior Valorisation of Juglans regia L. Leaves of Different Maturity through the Isolation of Bioactive Compounds

Tociu,

Manolache,

Bălănucă

et al. 2023

Molecules

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“…Oxidative stress, resulting from excessive generation of free radicals owing to a cellular reduction-oxidation imbalance, has been recognized as a contributor to many diseases, including Alzheimer disease, type 2 diabetes mellitus, hypertension and systemic inflammatory response syndrome (Forman & Zhang, 2021;Pisoschi & Pop, 2015). Therefore, antioxidant therapy was put forward as potential strategy to treat diseases associated with oxidative stress (Pasini & Cominacini, 2022;Xiao, Fu, et al, 2022). In spite of disappointing results for small antioxidant molecules in clinical trials (Forman & Zhang, 2021), the investigation of antioxidants with low toxicity and high efficiency has become a major research topic, especially for natural antioxidants (Ramana et al, 2018;_ Zyma nczyk-Duda et al, 2018).…”

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confidence: 99%

Qualitative and quantitative method for quality control of Itea ilicifolia based on antioxidant Q‐markers

Feng

Zhang

Yang

et al. 2023

Biomedical Chromatography

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Itea ilicifolia Oliv is a folk medicine with antioxidant potential. In this study, the fingerprints of 14 batches of I. ilicifolia were established by HPLC with 17 common peaks.The similarities evaluated by Similarity Evaluation System for Chromatographic Fingerprint of Chinese Materia (version 2012) were >0.89. Ten compounds were identified with definite structures by comparing the retention time and characteristic UV spectral pattern with those of reference substances. The antioxidant capacities of 14 batches of I. ilicifolia were evaluated based on O 2 ÁÀ , DPPH and ABTS Á+ radical scavenging assays in combination with ferric reducing antioxidant power assay. Via multivariate statistical analyses of gray relation analysis, bivariate correlation analysis and partial least squares regression analysis, a study on the spectrum-effect relationship was then performed to screen eight peaks as the antioxidant Q-markers of I. ilicifolia. The contents of representative antioxidant Q-markers (isoorientin, orientin, vitexin, isovitexin and iteafuranal A) in samples were accurately determined to be 0.

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Screening Antioxidant Components in Yiwei Decoction Using Spectrum‐Effect Relationship and Network Pharmacology

Zhang,

Zhu

2024

Journal of Analytical Methods in Chemistry

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Yiwei decoction (YWD) is a classic prescription with the function of nourishing stomach yin. In this study, the effective components of antioxidant activity of YWD and its possible mechanism were discussed from the point of view of spectral effect relationship and network pharmacology. Firstly, the fingerprints of 10 batches of YWD were established by UPLC‐PDA technique, and the 1,1‐diphenyl‐2‐picryl‐hydrazyl radical (DPPH) scavenging rate and total antioxidant capacity (T‐AOC) were used as the indicators for antioxidant activity in vitro. Then, the spectral effect relationship between the fingerprint profiles and antioxidant capacity was analyzed through grey relational analysis (GRA) and orthogonal projections to latent structures (OPLS). In addition, network pharmacology was employed to predict the potential mechanisms of YWD in the treatment of antioxidant‐related diseases. The spectrum‐effect relationship indicated that three common peaks were likely to be the most decisive active components, identified as verbascoside, psoralen, and vitexin, respectively. Based on network pharmacology analysis, a total of 83 target genes shared by the active components and antioxidant‐related diseases were collected. AKT1, HSP90AA1, SRC, CASP3, and MTOR were closely related to antioxidant therapy and considered as core therapeutic targets. The potential mechanisms of YWD were obtained through gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Finally, molecular docking simulations were conducted to evaluate the binding activities between the core therapeutic targets and corresponding compounds. The excellent core protein‐compound complexes obtained by molecular docking were simulated by molecular dynamics simulation. The results showed that the active compounds had good binding ability with the selected targets. This study successfully identified the effective components of YWD and predicted the potential targets and pathways, which provided a new idea for the application of YWD in the treatment of antioxidant stress in the future. In addition, the potential active components provide valuable implications for drug screening of related diseases.

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Effect of Antioxidant Therapy on Oxidative Stress in Vivo

Abstract: Over the last few decades, many efforts have been put into fields that explore the potential benefits of antioxidants, especially with regards to aging, cancer, cardiovascular diseases, and neurodegenerative diseases. [...]

Cited by 4 publications

References 31 publications

Superior Valorisation of Juglans regia L. Leaves of Different Maturity through the Isolation of Bioactive Compounds

Superior Valorisation of Juglans regia L. Leaves of Different Maturity through the Isolation of Bioactive Compounds

Qualitative and quantitative method for quality control of Itea ilicifolia based on antioxidant Q‐markers

Screening Antioxidant Components in Yiwei Decoction Using Spectrum‐Effect Relationship and Network Pharmacology

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