Effect of Antioxidants on Sperm Genetic Damage

Ménézo, Yves; Evenson, D.P.; Cohen, Marc; Dale, Brian

doi:10.1007/978-1-4614-7783-9_11

Cited by 33 publications

(22 citation statements)

References 71 publications

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“…The study shows that ginger powder in doses of 250 mg twice a day after 3 months is effective in reducing DNA fragmentation as compared with controls. This is the first direct demonstration of protective effect of ginger upon sperm DNA integrity in human although such an effect has previously been suggested with the use of other antioxidant (9, 23, 24). …”

Section: Discussionmentioning

confidence: 65%

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The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double-blind randomized clinical trial

Hosseini

Mamaghani

Hosseinifar

et al. 2016

IJRM

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Background:Although the effectiveness of ginger as an antioxidant agent has been exploited, little human research has been conducted on its activity on male reproductive functions.Objective:This study was designed to investigate the effects of ginger (Zingiber officinale) on sperm DNA fragmentation (SDF) in infertile men. Materials and Methods:This randomized double-blind, placebo-controlled trial with a 1:1 allocation was performed on 100 infertility treatment candidates who were admitted to Royan Institute for Reproductive Biomedicine, Tehran, Iran. Patients were randomly assigned to receive one of two treatments: ginger and placebo. Patients were given a 3-month oral treatment (members received capsules containing 250 mg of ginger powder twice a day in ginger and a placebo in other group). Before and after treatment, standardized semen samples were obtained to determine sperm concentration, motility, and SDF according to World Health Organization.Results:There was no significant difference between two groups regarding SDF at baseline (53.48. 95%CI: 37.95-69.02) in cases and (56.75, 95%CI: 40.01-73.5) in controls. The average positive percentage of SDF in patients receiving ginger (17.77, 95%CI: 6.16-29.39) was lower compared with placebo (40.54, 95%CI: 23.94-57.13) after three month of treatment (p=0.02). In multivariate analysis, SDF was significantly lower in patients receiving ginger compared with placebo (mean difference: 3.21, 95%CI: 0.78-5.63, p=0.009). There were no significant differences between two groups regarding to semen parameters.Conclusion:The present study has demonstrated that ginger in a controlled study of efficacy was effective in decreasing SDF in infertile men.

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Section: Discussionmentioning

confidence: 65%

“…Ginger also contains [6]-gingerol, 8-gingerol, 10-gingerol and 12-gingerol, which have similar anti-oxidate properties (27, 31). Animal modeling showed that ginger significantly lowered induced lipid peroxidation and amplified the levels of antioxidant enzymes, quantity and quality of sperm and plus serum glutathione (9, 16, 17, 32). …”

Section: Discussionmentioning

confidence: 99%

The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double-blind randomized clinical trial

Hosseini

Mamaghani

Hosseinifar

et al. 2016

IJRM

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“…18 Approximately 20 percent of modern couples are infertile worldwide, and about half of these couples have suffered from male infertility. 19 Therefore, it is important to develop effective preventive strategies for male infertility. As shown in the above reports, scrotal hyperthermia can induce severe oxidative damage to spermatogenesis, but curcumin might have potent antioxidant activities in disease control of humans and animals.…”

Section: Introductionmentioning

confidence: 99%

Curcumin dose-dependently improves spermatogenic disorders induced by scrotal heat stress in mice

et al. 2015

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Approximately 20% of couples worldwide are infertile and about half of these couples have male infertility. Therefore, it is important to develop effective strategies for preventing male infertility. In this study, we examined the effects and regulatory mechanisms of curcumin, an active ingredient in the traditional herbal treatment derived from the dietary spice turmeric (Curcuma longa), on exogenous scrotal heat stress-induced testicular injuries in mice. Adult mice were orally administered three different doses of curcumin (20, 40, or 80 mg per kg per day) for 14 consecutive days and then subjected to transient scrotal heat stress at 43 °C for 20 min on day 7. The testes and blood of the mice were collected on day 14. Mice exposed to heat stress showed low testicular weight, severe vacuolization of seminiferous tubules followed by loss of spermatogenic cells, and the appearance of multinucleated giant cells and degenerative Leydig cells. In addition, great changes in oxidative stress (lipid peroxidation, superoxide dismutase (SOD) activity, cytoplasmic SOD, mitochondrial SOD, and phospholipid hydroperoxide glutathione peroxidase mRNAs), apoptosis (B-cell lymphoma-extra large and caspase 3 mRNAs), heat shock reaction (heat shock transcription factor-1 and transforming growth factor-β1 mRNAs) and androgen biosynthesis (testosterone concentration and 3β-hydroxysteroid dehydrogenase mRNA) were observed. However, all these testicular injuries induced by the scrotal hyperthermia were significantly improved by curcumin treatment (20, 40 and 80 mg kg(-1)) in a dose-dependent manner via its antioxidative, anti-apoptotic and androgen synthesis effects, indicating that it has the potential to prevent male infertility.

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“…In 1980, sperm DNA integrity was first presented as an independent fertility marker by Evenson et al . Although there is no yet a clear evidence of its clinical significance (Barratt & De Jonge, ), a number of studies have demonstrated that the proportion of sperm with fragmented DNA appears to be higher in infertile males compared with fertile controls (Agarwal & Said, ; Menezo et al ., ). Moreover, Perrin et al .…”

Section: Sperm Aneuploidy Predictive Factorsmentioning

confidence: 97%

Sperm aneuploidy in infertile male patients: a systematic review of the literature

Chatziparasidou

Christoforidis

Samolada³

et al. 2014

Andrologia

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Males with abnormal karyotypes and subgroups of fertile and infertile males with normal karyotypes may be at risk of producing unbalanced or aneuploid spermatozoa. Biological, clinical, environmental and other factors may also cause additional sperm aneuploidy. However, increased risk of sperm aneuploidy is directly related to chromosomally abnormal embryo production and hence to poor reproductive potential. This systemic literature review focuses on the identification of these males because this is an essential step in the context of assisted reproduction. This research may allow for a more personalised and, hence, more accurate estimation of the risk involved in each case, which in turn will aid genetic counselling for affected couples and help with informed decision-making.

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Effect of Antioxidants on Sperm Genetic Damage

Cited by 33 publications

References 71 publications

The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double-blind randomized clinical trial

The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double-blind randomized clinical trial

Curcumin dose-dependently improves spermatogenic disorders induced by scrotal heat stress in mice

Sperm aneuploidy in infertile male patients: a systematic review of the literature

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