Abstract:Objective:The objective of the present study was to evaluate the effect of aqueous enriched fraction of Premna integrifolia root (AEFPIR) against cafeteria diet induced obesity in Swiss albino mice. Materials and Methods: Female Swiss albino mice were divided into four groups, which received cafeteria diet, standard drug simvastatin (10 mg/kg) and AEFPIR (200 and 400 mg/kg) daily for 40 days. The body weight, body mass index (BMI), food consumption, serum glucose, triglyceride, total cholesterol, high density … Show more
“…Reduction in body weights of experimental rats treated with HAE might be due to the anti-obesity potential of HAE in a dose-dependent manner. The result of the present study was in agreement with that of aqueous extract of root of P. integrifolia reported [12] , [28] . Fig.…”
Premna integrifolia Linn. is a medicinal plant used in “Dhasamula” drug preparation of Ayurvedic systems of medicine in the treatment of various ailments like bronchitis, dyspepsia, liver disorders, piles, constipation, hyperlipidemia and fever. The anti-atherosclerotic activity of hydroalcoholic extract (HAE) of root bark of P. integrifolia was evaluated in high fat diet induced atherosclerosis rats. Sixty Wistar rats were divided into six groups: the first group served as control, the second group was fed with high fat diet and the other three groups were fed with high fat diet along with various concentrations of HAE and the last group was treated with atorvastatin for 30 days. Lipid and lipoprotein profile, atherogenic index, and cardiac markers and histopathological evaluation of aorta were determined in high fat diet induced atherosclerosis rats. HAE of P. integrifolia produced a significant and dose-dependent anti-atherosclerotic activity in terms of reduction in lipids and lipoprotein profile, atherogenic index, HMG-CoA reductase activity, marker enzymes such as lactate dehydrogenase (LDH), creatine phosphokinase (CPK), aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP), alteration in collagen and calcium contents, mild mineralization and focal rupture of intima and media of aorta was noticed in treated groups as compared to the control. The results suggested that anti-atherosclerotic activity of HAE of P. integrifolia Linn. was due to its modulatory activity on metabolic pathway of lipid. The results contribute to the validation of the traditional use of Agnimantha in high fat diet induced atherosclerosis rats.
“…Reduction in body weights of experimental rats treated with HAE might be due to the anti-obesity potential of HAE in a dose-dependent manner. The result of the present study was in agreement with that of aqueous extract of root of P. integrifolia reported [12] , [28] . Fig.…”
Premna integrifolia Linn. is a medicinal plant used in “Dhasamula” drug preparation of Ayurvedic systems of medicine in the treatment of various ailments like bronchitis, dyspepsia, liver disorders, piles, constipation, hyperlipidemia and fever. The anti-atherosclerotic activity of hydroalcoholic extract (HAE) of root bark of P. integrifolia was evaluated in high fat diet induced atherosclerosis rats. Sixty Wistar rats were divided into six groups: the first group served as control, the second group was fed with high fat diet and the other three groups were fed with high fat diet along with various concentrations of HAE and the last group was treated with atorvastatin for 30 days. Lipid and lipoprotein profile, atherogenic index, and cardiac markers and histopathological evaluation of aorta were determined in high fat diet induced atherosclerosis rats. HAE of P. integrifolia produced a significant and dose-dependent anti-atherosclerotic activity in terms of reduction in lipids and lipoprotein profile, atherogenic index, HMG-CoA reductase activity, marker enzymes such as lactate dehydrogenase (LDH), creatine phosphokinase (CPK), aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP), alteration in collagen and calcium contents, mild mineralization and focal rupture of intima and media of aorta was noticed in treated groups as compared to the control. The results suggested that anti-atherosclerotic activity of HAE of P. integrifolia Linn. was due to its modulatory activity on metabolic pathway of lipid. The results contribute to the validation of the traditional use of Agnimantha in high fat diet induced atherosclerosis rats.
“…The AEFPIR (400 mg/kg) supplementation attenuated all the above alterations, which indicates the protective effect against cafeteria diet induced obesity that was further confirmed by histopathological analysis. [ 41 ] Hypolipidemic activity was also evaluated using hypercholesterolemic rabbit model in comparison to the established hypolipidemic drug atorvastatin. Lipid profile which includes total cholesterol, triglyceride, LDL, VLDL, HDL, fasting blood glucose and body weight were measured (i) at baseline, (ii) after 6 weeks of cholesterol feeding and (iii) 12 weeks i.e.…”
Premna integrifolia Linn. (Verbenaceae) is an important constituent of the formulation of ten roots of herbs known as Daśamūla and is widely used for treating various ailments in the Indian system of medicine. Aim of this review is to provide comprehensive information on the pharmacological activities of various parts of P. integrifolia. All the relevant universally accepted electronic databases were searched with respect to the terms “Agnimanthā”, “Headache tree”, “Premna integrifolia”, “Premna obtusifolia”, “Premna serratifolia” including Indian classical texts, pharmacopoeias, Ayurvedic books, journals, etc., for information without specific timeline. Complete information of the plant has been collected manually since the year 1964 and has been arranged chronologically. The collected data reflects that many ethno-medicinal claims have been confirmed through the modern in-vitro and in-vivo pharmacological studies using different extracts and their isolates of P. integrifolia. The isolation of active constituents, their biological actions, clinical safety and validation of traditional uses of P. integrifolia could provide leads for further scientific research. The information collected here will be useful to set-up research protocols for modern drugs and Ayurvedic formulation development.
“… 2003 ). This activity was further evaluated by Mali ( 2013 ) using cafeteria diet induced mice (inbreed) through various parameters (body-mass index, blood glucose, lipid profile, histology valuation) and comparison with a standard drug (simvastatin). The findings indicated significant protective effect of the roots of P. integrifolia at doses of 200 and 400 mg/kg.…”
Section: Pharmacological Activitiesmentioning
confidence: 99%
“… 2004c ). Meanwhile, Mali ( 2013 ) reported the effect of P. integrifolia roots on lipid profile parameters of caffeinated-diet mice. Additionally, the antihyperlipidemic effect of the leaves and roots of P. esculenta was evaluated in vivo by using Poloxamer 407-induced hyperlipidemis mice and rats (Mahmud et al.…”
Context: The genus Premna (Lamiaceae), distributed throughout tropical and subtropical Asia, Africa, Australia and the Pacific Islands, is used in folk medicine primarily to treat inflammation, immune-related diseases, stomach disorders, wound healing, and skin diseases.
Objectives: This review exhaustively gathers available information on ethnopharmacological uses, phytochemistry, and bioactivity studies on more than 20 species of Premna and critically analyzes the reports to provide the perspectives and directions for future research for the plants as potential source of drug leads and pharmaceutical agents.
Methods: A literature search was performed on Premna species based on books of herbal medicine, major scientific databases including Chemical Abstract, Pubmed, SciFinder, Springerlink, Science Direct, Scopus, the Web of Science, Google Scholar, and ethnobotanical databases.
Results: More than 250 compounds have been isolated and identified from Premna species, comprising of diterpenoids, iridoid glycosides, and flavonoids as the most common secondary metabolites, followed by sesquiterpenes, lignans, phenylethanoids, megastigmanes, glyceroglycolipids, and ceramides. Many in vitro and in vivo studies have been conducted to evaluate the biological and pharmacological properties of the extracts, and isolated compounds of Premna species with antimicrobial, antioxidant, anti-inflammatory, immunomodulatory, antihyperglycaemia, and cytotoxic activities.
Conclusion: The bioactive compounds responsible for the bioactivities of most plants have not been well identified as the reported in vivo pharmacological studies were mostly carried out on the crude extracts. The isolated bioactive components should also be further subjected to more preclinical studies and elaborate toxicity study before clinical trials can be pursued.
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