Effect of Aqueous Extract of Zingiber officinale (Ginger) on Some Biochemical Parameters in Streptozotocin-induced Diabetes Rats

Abstract

Background: Appreciable number of medicinal plants are used for the treatment of diabetes in Nigeria. Aim of the Study: The present study aimed to investigate the antidiabetic activity of Zingiber officinale extracts and its potential mechanisms in streptozotocin-induced diabetic rats. Methodology: Albino rats of Wistar strain weighing between 130 g to 160 g were induced with single freshly prepared streptozotocin (55 mg/kg body weight). Diabetes was confirmed after forty eight hours in streptozotocin -induced rats showing fasting blood glucose levels > 10 mmol/l. The rats were randomly divided into four (4) experimental groups (n = 4). A (Control diabetic group fed with normal feed), Group B (Normal control fed with normal feed), Group Group C (Diabetic rats treated with 400 mg/Kg body weight extract of ginger and Group D, (Diabetic rats are treated with 400 mg/Kg body weight of metformin). After 8 days the animals were sacrificed and blood samples Jiyil et al.; AJRIMPS, 8(1-2): 1-8, 2019; Article no.AJRIMPS.51900 2 were collected for biochemical and hematological analysis. Changes in the animal body weights were also measured within the period. Results: From the results, it was observed that treatment of rats with extract of ginger compensates for the reduction of body weight, and caused an increase in the body weight of the treated rats (+11.5%) in contrast to 24.8% reduction observed in diabetic control. In the same order, serum glucose significantly decreased (p<0.05) after the 8-day treatment compared to diabetic control. The extent of reversal of hyperglycemia in the ginger extract treated animals compared well with the metformin treated group. The results, therefore, showed that ginger extract has a significant (p<0.05) hypoglycemic effect in diabetic rats and moreover, elevations in the measured biochemical parameters were significantly (p<0.05) attenuated in rats treated with ginger extract. Conclusion: Zingiber officinale extracts has a significant effect on some biochemical parameters and hematological assays. These provide scientific evidence to confirm the traditional use of Z. officinale in the treatment of diabetes mellitus. Original Research Article

Renoprotective effects of the ginger (Zingiber officinale) on Diabetic kidney disease, current knowledge and future direction: a systematic review of animal studies

“…The reduction of TC and TG were also reported by 15 [ 21 , 26 , 29 , 30 , 34 , 35 , 38 , 41 , 44 , 49 , 52 , 54 , 56 , 59 , 60 ] and 14 [ 21 , 26 , 29 , 30 , 34 , 35 , 38 , 41 , 44 , 49 , 52 , 56 , 59 , 60 ] studies respectively. Ginger has been shown to improve low-density lipoprotein-cholesterol (LDL-C) [ 26 , 29 , 30 , 35 , 38 , 52 , 54 , 56 , 59 ] and high-density lipoprotein-cholesterol (HDL-C) [ 26 , 29 , 30 , 35 , 38 , 49 , 56 , 59 , 60 ] levels in nine studies. One study reported contradictory results for TC, TG, and LDL-C, as well as two studies for HDL-C [ 23 , 44 ].…”

“…Twenty-eight of 31 studies showed that ginger intake lowers blood glucose levels [ 24 , 25 , 27 , 29 , 30 , 34 – 43 , 47 – 49 , 51 – 53 , 55 – 61 ]. On the contrary, in 2 studies, blood glucose levels increased [ 22 , 23 ].…”

Renoprotective Effects of the Ginger (Zingiber officinale) in Diabetic Kidney Disease, Current Knowledge and Future Direction: A Systematic Review of Animal Studies

“…In all studies the impact of ginger on the antioxidant defense system was evaluated, positive results were found. In all studies, ginger elevated the level of GSH [15,19,20,24,28,29,36,49,50], CAT, SOD [15,22,24,36], GR [24,28], GPx [19,22,24,28] and TAC [38,40,53,57] factors. Similarly 2 studies reported that administration of ginger decreased ROS levels [24,50].…”

“…On the contrary, creatinine levels were increased in one study [32] and not changed in 3 studies [18, 47,53]. Ginger decreased serum levels of urea, BUN, and uric acid in 13 [15-17, 19-21, 23, 29, 30, 34, 36, 47, 53], 6 [15,18,22,24,49,50], and 6 [17,20,22,29,30,43] studies, respectively. On the contrary, urea and uric acid levels were increased in one study [33].…”

“…Intervention durations ranged from 2 to 16 weeks. Location of studies performed as follows: 9 in Egypt [15][16][17][18][19][20][21][22][23], 8 in India [24][25][26][27][28][29][30][31], 6 in Saudi Arabia [32][33][34][35][36][37], 4 in Iran [38][39][40][41], 3 in Kuwait [42][43][44], 3 in Pakistan [45,46], 2 in Nigeria [47,48], 2 in China [49,50], 1 in South Korea [51], Jordan [52], Iraq [53] and Malaysia [54]. Studies were done from 2006 to2021.…”