Effect of aqueous extract of Ajuga iva supplementation on plasma lipid profile and tissue antioxidant status in rats fed a high-cholesterol diet

Chenni, A.; Yahia, Dalila Ait; Boukortt, Farida; Prost, Josiane; Lacaille‐Dubois, Marie‐Aleth; Bouchenak, Malika

doi:10.1016/j.jep.2006.05.036

Cited by 60 publications

(34 citation statements)

References 32 publications

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“…As, hypercholesterolemia induces cellular oxidative stress, to protect cells or tissues antioxidant systems have to fight against this. Due to hypercholesterolemia, the antioxidant systems are supposed to be altered usually [1,2,8]. In this study, it has been found that all the studied parameters (GSH, TBARS, SOD, GPx and catalase) were altered in the liver of hypercholesterolemic rats significantly, except catalase activity (catalase activity was lower in HC group than in control, but the difference was nonsignificant).…”

Section: Discussionmentioning

confidence: 62%

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Pleurotus sajor-caju and Pleurotus florida Mushrooms Improve Some Extent of the Antioxidant Systems in the Liver of Hypercholesterolemic Rats

Rahman¹,

Tania²,

Uddin³

et al. 2011

TONUTRAJ

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Abstract:Objectives: There is evidence that the antioxidant systems are imbalanced in hypercholesterolemic rats due to oxidative stress. Dietary supplementation of Pleurotus sajor-caju and P. florida are anti-hypercholesterolemic in rats. In this study, it was investigated whether these mushrooms have any effects on the antioxidant systems in hypercholesterolemic rat liver, which are altered.Methods: Twenty young Long-Evans rats were randomly divided into 4 groups: control (fed basal diet), HC (fed 1% cholesterol with basal diet), HC+PS (fed 5% P. sajor-caju powder with 1% cholesterol and basal diet) and HC+PF (fed 5% P. florida powder with 1% cholesterol and basal diet). Rats were fed for 40 days, and then after sacrifice livers were collected, washed and homogenized. The content of reduced glutathione (GSH), thiobarbituric acid reactive substance (TBARS), and the activity of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) in homogenate were measured.Results: All the studied parameters were altered in hypercholesterolemic rats significantly in comparison with control group, except catalase (non-significant). Feeding of P. florida protected liver lipid peroxidation in hypercholesterolemic rat, as TBARS was significantly lower (by 34.5%) in HC+PF group than in HC group. Feeding of both mushrooms showed significant improvement in the activity of GPx in liver of hypercholesterolemic rats (in HC+PS and HC+PF, the activity was higher by 50% and 80%, respectively than in HC group). However, mushroom feeding showed no significant effect on GSH level, SOD and catalase activity in hypercholesterolemic rats. Conclusion:This investigation confirms the antioxidant activities of P. sajor-caju and P. florida to some extent in hypercholesterolemic rats in addition to their anti-hypercholesterolemic activity.

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Section: Discussionmentioning

confidence: 62%

“…Hypercholesterolemia is also related to diabetes and it has role in inducing oxidative stress [1,2]. Oxidative stress is thought to contribute to the development of a wide range of diseases including Alzheimer's disease, Parkinson's disease, neurodegeneration, aging etc.…”

Section: Introductionmentioning

confidence: 99%

Pleurotus sajor-caju and Pleurotus florida Mushrooms Improve Some Extent of the Antioxidant Systems in the Liver of Hypercholesterolemic Rats

Rahman¹,

Tania²,

Uddin³

et al. 2011

TONUTRAJ

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“…It was reported that blood lipid was markedly decreased by intravenous injection combined with concomitant oral administration of Flos Lonicerae extract for cases of hyperlipidemia (Chang and But, 1986). We suspect that the activity of Flos Lonicerae extract may be linked with its antioxidant components, because antioxidants have been thought to be involved in reducing production of free radicals and arterial deposition of cholesterol as well as blood lipid (Chang and But, 1986;Chenni et al, 2007;Durak et al, 2004;Fernández-Checa, 2003;Joshi et al, 2001;Ramkumar et al, 2003;Yang et al, 2006;Zhang et al, 2001).…”

Section: Determination Of Antioxidant Activity Of Flos Lonicerae Extrmentioning

confidence: 96%

Effect of chlorogenic acid on antioxidant activity of Flos Lonicerae extracts

Lan

2007

J. Zhejiang Univ. - Sci. B

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Abstract:Flos Lonicerae is a medically useful traditional Chinese medicine herb. However, little is known about the antioxidant properties of Flos Lonicerae extracts. Here the antioxidant capacity of water, methanolic and ethanolic extracts prepared from Flos Lonicerae to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and reduce Fe 3+ to Fe 2+ is examined. Chlorogenic acid, a major component of Flos Lonicerae, is identified and further purified from 70% ethanolic extract with high performance liquid chromatography (HPLC) and its antioxidant capacity is characterized. The total phenolic compounds and chlorogenic acid contents in Flos Lonicerae are determined. The present results demonstrate that the Flos Lonicerae extracts exhibit antioxidant activity and chlorogenic acid is a major contributor to this activity.

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“…The levels of cholesterol, triglyceride, highdensity lipoprotein, low-density lipoprotein, and levels of alanine transaminase, aspartate transaminase and alkaline phosphatase in both the serum and tissues were determined spectrophotometrically by Hitachi U-2000 spectrophotometer on the same day [10].…”

Section: Biochemical Studiesmentioning

confidence: 99%

Combinatorial Effects of Aqueous Root Extract of Jatropha Curcas and J. Gossypiifolia in Alloxan-Induced Diabetic Rats

Aladodo

Balogun

Sunmonu

et al. 2017

IJT

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Effect of aqueous extract of Ajuga iva supplementation on plasma lipid profile and tissue antioxidant status in rats fed a high-cholesterol diet

Cited by 60 publications

References 32 publications

Pleurotus sajor-caju and Pleurotus florida Mushrooms Improve Some Extent of the Antioxidant Systems in the Liver of Hypercholesterolemic Rats

Pleurotus sajor-caju and Pleurotus florida Mushrooms Improve Some Extent of the Antioxidant Systems in the Liver of Hypercholesterolemic Rats

Effect of chlorogenic acid on antioxidant activity of Flos Lonicerae extracts

Combinatorial Effects of Aqueous Root Extract of Jatropha Curcas and J. Gossypiifolia in Alloxan-Induced Diabetic Rats

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