Combinatorial Effects of Aqueous Root Extract of Jatropha Curcas and J. Gossypiifolia in Alloxan-Induced Diabetic Rats

Aladodo, Raliat Abimbola; Balogun, Elizabeth Abidemi; Sunmonu, Taofik O.; Nurain, Ismaila Olanrewaju

doi:10.29252/arakmu.11.1.11

Cited by 8 publications

(11 citation statements)

References 16 publications

(14 reference statements)

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“…Diabetes mellitus has been characterized by anaemia as reported by, 37 which is supported by the present study especially in diabetic control rats ( Table 2 ). This might due to excess glucose in the hemoglobin, results in glycosylated hemoglobin with decrease in red blood cell (RBC) and packed cell volume (PCV), an indicator of imbalance between its synthesis and destruction.…”

Section: Resultssupporting

confidence: 90%

Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic Rats

et al. 2018

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Purpose: Diabetes mellitus is one of the major endocrine disorders, characterized by impaired insulin action and deficiency. Traditionally, Artocarpus heterophyllus stem bark has been reputably used in the management of diabetes mellitus and its complications. The present study evaluates the ameliorative activity of ethanol extract of Artocarpus heterophyllus stem bark in alloxan-induced diabetic rats.Methods: Diabetes mellitus was induced by single intraperitoneal injection of 150 mg/kg body weight of alloxan and the animals were orally administered with 50, 100 and 150 mg/kg body weight ethanol extract of Artocarpus heterophyllus stem bark once daily for 21 days.Results: At the end of the intervention, diabetic control rats showed significant (p<0.05) weight reduction, abnormal haematological parameters, high serum lipids (except high density lipoprotein) concentrations, increased creatinine, bilirubin and urea levels with decreased in albumin level when compared with non-diabetic control rats. All these alterations were reverted to normal after administered with different doses of ethanol extract of Artocarpus heterophyllus stem bark most especially at 150 mg/kg body weight which exhibited no significant (p>0.05) different with non-diabetic rats.Conclusion: The results suggest that ethanol extract of Artocarpus heterophyllus stem bark may be useful in ameliorating complications associated with diabetes mellitus patients.

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Section: Resultssupporting

confidence: 90%

Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic Rats

et al. 2018

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“…Hyperglycemia reoccurrence during diabetes leads to body proteins being glycated, that successively results in complications affecting body organs and arteries [5]. Stiffening of red blood cells could be liable for and or related to, large vessel disease in diabetes state [6]. Management option for DM is predicated on insulin therapy and oral hypoglycemic agents that have several facet effects [7].…”

Section: Introductionmentioning

confidence: 99%

“…Management option for DM is predicated on insulin therapy and oral hypoglycemic agents that have several facet effects [7]. In diabetes state, the effects and locations of involvement in biochemical activity are varied and elevated serum total triglyceride level, increase level of transaminase, creatinine and urea are of concerned [6]. Additional major issue, that confounds diabetic state, leading to death is hyperlipidemia [8].…”

Section: Introductionmentioning

confidence: 99%

Antihyperlipidemic Activities and Hematological Properties of Ethanol Extract of Blighia Sapida Koenig Bark in Alloxan-Induced Diabetic Rats

Ojo

Ojo²,

Ajiboye

et al. 2020

Serbian Journal of Experimental and Clinical Research

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Blighia sapida (BS) has been shown to be rich sources of antioxidant, thus, we evaluated effects of B. sapida Koenig stem bark ethanol extract (BSE) on lipid metabolism and hematological indices in diabetes rats. Thirty male rats were divided into six groups of five rats each. Diabetes was elicited by intraperitoneal injection of alloxan (65 mg/kg body weight) once and orally administered with glibenclamide (5 mg/kg), B. sapida extract (50, 100 and 150 mg/kg body weight (bw) once daily for 21 days. Serum lipid profile, markers of hepato-renal toxicity and hematological indices were examined using automated analyzer. Data were analyzed using one-way ANOVA and p < 0.05 was considered to be statistically different. Diabetic untreated animals showed considerably elevated total cholesterol p < 0.05, also, significant increase in AST, ALT, ALP, urea and creatinine compared to control. Triglycerides, LDL-c, VLDL-c, AI and CRI decreased with extract administration and HDL-c increased considerable compared to untreated diabetic rats. Furthermore, significant lower hemoglobin (Hb) levels, packed cell volume (PCV), red blood cells (RBCs) levels, white blood cells (WBCs) compared to normal animals was recorded in the untreated group. These changes were returned to normal after the administration of extract 50, 100 and 150 mg/ kg body weight. Hence, these effects were most prominent in the animals treated with 150 mg/kg body weight of B. sapida bark. This indicates that B. sapida stem bark possess anti-hyperlipidemic activity and improved the biochemical parameters within the hematological profile of diabetic rats.

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“…Diabetes mellitus is a multi-systemic complex disorder primarily caused by absolute or relative insulin deficiency that deprives the body the ability to effectively carry out glucose homeostasis (Aladodo et al 2013, Ezeja et al 2014). Diabetes mellitus may occur due to impairment of β-cells of the pancreas that thus decreases the secretion of insulin.…”

Section: Introductionmentioning

confidence: 99%

Nutrient composition and ameliorative effects of Cocos nucifera products on Alloxan-induced diabetic wistar rats

Augustine

Charity

Amadi

et al. 2017

IJM

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Using standard methods, this study investigated the ameliorative effects of coconut products during alloxan-induced diabetic conditions. Experimental animals were divided into five groups, group 1 served as normal control rats fed only rat chow and saline, group 2 were diabetic control rats intraperitoneally treated with 150mg/kg body weight alloxan monohydrate, group 3 were diabetic rats orally treated with 4ml/day of coconut milk, group 4 were diabetic rats orally treated with 4ml/day of coconut water, and group 5 were diabetic rats orally treated with 4ml/day of a mixture of coconut milk and coconut water. The coconut products had high moisture, fats, potassium, magnesium, and sodium contents. Coconut milk exhibited the most effective glucose lowering effect, and on the 21st day. The total cholesterol was completely normalized on treatment with coconut milk after alloxan induced diabetes, while the administration of the mixture of coconut milk and water had a comparable effect to administering only coconut milk on HDL, LDL, and TG. The alloxan-induced derangements on SOD, catalase and GPx were completely normalized after the coconut milk administration, while the mixture of coconut milk and water restored only SOD and GPx, and coconut water, ineffective on most of the antioxidant enzymes. Coconut water was ineffective on the RBC and HB of diabetic rats, while coconut milk and the mixture of coconut milk and water showed the most hematoameliorative effect. This study has shown the effectiveness of coconut products in the management of diabetes, with coconut milk the most effective.

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Combinatorial Effects of Aqueous Root Extract of Jatropha Curcas and J. Gossypiifolia in Alloxan-Induced Diabetic Rats

Abstract: Background: Combinatorial effects of aqueous root extract of Jatropha curcas (Jc) and J.

Cited by 8 publications

References 16 publications

Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic Rats

Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic Rats

Antihyperlipidemic Activities and Hematological Properties of Ethanol Extract of Blighia Sapida Koenig Bark in Alloxan-Induced Diabetic Rats

Nutrient composition and ameliorative effects of Cocos nucifera products on Alloxan-induced diabetic wistar rats

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