Effect of aqueous extracts of Achyranthes aspera Linn. on experimental animal model for inflammation

Bhosale, Uma A; Yegnanarayan, Radha; Pophale, Prachi; Somani, Rahul

doi:10.4103/0257-7941.107362

Cited by 41 publications

(17 citation statements)

References 5 publications

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“… Amaranthaceae Leaves Pneumonia and asthma Antihistaminic, anti-inflammatory, mast cell stabilizer and bronchoprotective effect. Inhibits action of histamine, acetylcholine and 5-HT [ 139 , 140 ] Albizia lebbeck Benth Moraceae Bark Flu, cough, lung problems Bronchodialator, Anti-allergic, Mast cell stabilizing property due to histamine release and cytokine expression of antigen –ige activated mast cells [ 141 , 142 ] Alstonia scholaris Fabaceae Bark, Leaves Asthma Bronchodialator, anti-tussive effect against sulfur dioxide induced mice coughing and citric acid induced guinea pigs coughing. Anti-asthmatic activity against histamine induced bronchoconstriction [ 143 , 144 ] Althaea officinalis L. Lythraceae Flowers, leaves, roots, fruits Asthma and bronchitis Cough suppressant activity in citric acid-induced cough reflex [ 145 ] Artemisia vulgaris Asclepiadaceae Leaves Asthma Bronchodilator due to anticholinergic and Ca 2+ antagonist mechanisms [ 146 ] Artemisia maritime Asteraceae Aerial parts Cough Bronchodilator activities mediated possibly through dual blockade of calcium channels and phosphodiesterase [ 102 ] Adhatoda vasica Capparidaceae Whole plant Cough, bronchitis, asthma Antiallergic, anti-anaphylact...…”

Section: Resultsmentioning

confidence: 99%

Traditional medicinal plants used for respiratory disorders in Pakistan: a review of the ethno-medicinal and pharmacological evidence

et al. 2018

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Respiratory disorders are a common cause of malady and demise in Pakistan due to its remoteness, cold and harsh climatic conditions as well as scarce health care facilities. The people rely upon the indigenous plant resources to cure various respiratory disorders. The primary objective of this review was to assemble all available ethno-medicinal data of plants used for respiratory disorders in Pakistan. Pharmacological activity of these plants (based upon published scientific research), distribution, diversity, use, preparation methods, economical value, conservation status and various available herbal products of some plants have also been explored. This study scrutinized various electronic databases for the literature on medicinal plants used in Pakistan to treat respiratory disorders. A total of 384 species belonging to 85 families used to treat respiratory disorders in Pakistan has been documented. Cough was the disorder treated by the highest number of species (214) followed by asthma (150), cold (57) and bronchitis (56). Most of the plants belongs to Asteraceae (32) and Solanaceae family (32) followed by moraceae (17), Poaceae (13), and Amaranthaceae (13) with their habit mostly of herb (219) followed by Shrub (112) and tree (69). Traditional healers in the region mostly prepare ethno medicinal recipes from leaves (24%) and roots (11%) in the form of decoction. Among the reported conservation status of 51 plant species, 5 were endangered, 1 critically endangered, 11 vulnerable, 14 rare, 16 least concern, 3 infrequent and 1 near threatened. We found only 53 plants on which pharmacological studies were conducted and 17 plants being used in herbal products available commercially for respiratory disorders. We showed the diversity and importance of medicinal plants used to treat respiratory disorders in the traditional health care system of Pakistan. As such disorders are still causing several deaths each year, it is of the utmost importance to conduct phytochemical and pharmacological studies on the most promising species. It is also crucial to increase access to traditional medicine, especially in rural areas. Threatened species need special attention for traditional herbal medicine to be exploited sustainably.

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Section: Resultsmentioning

confidence: 99%

Traditional medicinal plants used for respiratory disorders in Pakistan: a review of the ethno-medicinal and pharmacological evidence

et al. 2018

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“…ere is a research telling us that oxymatrine, which is one of the effective constituents of Radix Sophorae Flavescentis, exerts cardioprotective effect by preventing ventricular remodelling, myocardial hypertrophy, and myocardial fibrosis [12]. Other studies have indicated that Herba Achyranthis Asperae not only exhibits promising anti-inflammatory activity but also shows significant gastroprotective activity [13,14].…”

Section: Introductionmentioning

confidence: 99%

Safety and Efficacy Evaluation of Traditional Chinese Medicine (Qingre‐Lishi‐Yishen Formula) Based on Treatment of Regular Glucocorticoid Combined with Cyclophosphamide Pulse in Children Suffered from Moderately Severe Henoch–Schonlein Purpura Nephritis with Nephrotic Proteinuria

Fan

Zhen

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Objective. At present, the most appropriate management of Henoch–Schonlein purpura nephritis (HSPN) with nephrotic-range proteinuria still remains controversial; thus, the purpose of this study is to evaluate safety and efficacy of traditional Chinese medicine (TCM), Qingre-Lishi-Yishen Formula (QLYF), integrated with regular oral glucocorticoid and cyclophosphamide intravenous pulse therapeutic regimen in children suffered from moderately severe HSPN with nephrotic proteinuria. Methods. From 1 January 2012, to 1 January 2016, totally 150 hospitalized children suffered from HSPN with nephrotic proteinuria were included. All were treated with glucocorticoid and cyclophosphamide, and 100 of them were treated with integrative traditional Chinese decoction QLYF. Patients were followed up for 2 years. Rate of adverse event occurrence, short-term clinical effects, long-term clinical effects, and TCM therapeutic evaluation were all compared. Results. Total adverse event rate was lower in the QLYF group (χ2 = 5.357, p=0.022); rates of respiratory infection, urinary infection, poor appetite, hepatotoxity, cardiotoxicity, and neutropenia were all decreased in patients who received QLYF (p<0.05), and no cases of hepatic and renal toxicities related to the herbal medicine were observed in the QLYF group. For short-term clinical efficacy evaluation, lower levels of 24 hour proteinuria (p<0.05) and urine blood cell count (p<0.05) were found in the QLYF group. For long-term efficacy evaluation, better clinical control rate effective rate, lower recurrence rate (p<0.05), and fewer TCM syndrome score (p<0.05) were found in the QLYF group. Conclusion. Compared with merely using regular oral glucocorticoid plus cyclophosphamide pulse therapeutic regimen, the therapeutic regimen that integrates QLYF with the abovementioned western medicine might be a safe means to decrease the occurrence rate of adverse events and improve short-term and long-term clinical effects in children who suffered from moderately severe HSPN with nephrotic proteinuria.

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“…One of the medicinal plants currently being developed is Sangketan (Achyranthes aspera L.). The plant is reported to have several medicinal properties and is used as an emmenagogue, purgative, diuretic, antimalarial, antihyperlipidemic, estrogenic, antileprotic, antispasmodic, cardiotonic, antibacterial, and antiviral agent in various traditional systems of medicine [3][4][5][6][7]. However, the raw material (Simplicia) and the extract needed to undergo a thorough standardization process.…”

Section: Introductionmentioning

confidence: 99%

Determination of Specific and Non-Specific Parameters of the Simplicia and Ethanol Extract of Sangketan (Achyranthes Aspera L.) Leaves

Harahap

Elya²,

Noviani

2020

Int J App Pharm

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Objective: With recent advancements in traditional medicine, there is an increasing need for quality assurance assessments using standardizedprocesses. In this study, we aimed to determine the specific and non-specific parameters of the Simplicia and 70% ethanol extract of Achyranthesaspera leaves from three different regions.Methods: Samples were extracted using a maceration method with 70% ethanol as the solvent. The tests for the specific and non-specific parameterswere based on the Herbal Pharmacopoeia of Indonesia.Results: Our results of the specific parameters of the Simplicia showed that the ethanol-soluble extract contained 5.83–9.36% and the water-solubleextract contained 10.25–15.44%. The chromatogram pattern used β-sitosterol as the standard, and the total phenolic content was 0.93–1.15 mg gallicacid equivalent (GAE)/g Simplicia. The results of the non-specific parameters of Simplicia showed a loss on drying of 15.25–15.91%, a total ash contentof 14.58–20.79%, and an acid-insoluble ash value of 1.75–2.19%.Conclusion: Our results of the specific parameters of A. aspera extract showed a total phenolic content of 6.49–7.68% mg GAE/g extract. Our resultsof the non-specific parameters of the extract showed a total ash value of 13.18–14.52%, an acid-insoluble ash value of 0.14–0.29%, and a moisturecontent of 10.42–11.16%.

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Effect of aqueous extracts of Achyranthes aspera Linn. on experimental animal model for inflammation

Cited by 41 publications

References 5 publications

Traditional medicinal plants used for respiratory disorders in Pakistan: a review of the ethno-medicinal and pharmacological evidence

Traditional medicinal plants used for respiratory disorders in Pakistan: a review of the ethno-medicinal and pharmacological evidence

Safety and Efficacy Evaluation of Traditional Chinese Medicine (Qingre‐Lishi‐Yishen Formula) Based on Treatment of Regular Glucocorticoid Combined with Cyclophosphamide Pulse in Children Suffered from Moderately Severe Henoch–Schonlein Purpura Nephritis with Nephrotic Proteinuria

Determination of Specific and Non-Specific Parameters of the Simplicia and Ethanol Extract of Sangketan (Achyranthes Aspera L.) Leaves

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