In the animal farm affiliated with the college of Agriculture/ University of Anbar / Ramadi/ Iraq, this study was conducted to examine the Selenomethionine or yeast enriched with Selenium on antioxidant and some blood characteristics in Iraqi ewes. The study started on the twenty-sixth of July /2022 until the twenty-seventh of January / 2023. Eighteen ewes with an average of age 2 - 3 years and 43 ± 2.5 kg of average body weight (bw) had used. This animal had divided randomly in to three equal groups (each group had six ewes). All ewes had fed on the same ration. Group (1) had considered as a control group and left without treatment, group (2) had treated with Selenomethionine with a dose (0.03 g/kg/bw), while group (3) had treated with yeast enriched with Selenium (Saccharomyces cerevisiae- Selenium) with a dose (0.03 g/kg/bw), agreeing to NRC (1980). The animals had treated for 45 days by dissolving the samples in 30 ml of distilled water and given orally. The samples of blood had collected from the jugular vein during first day (first period), 14th day (second period), 19th day (third period) and 45th day (fourth period) for determine changing in the levels of enzymes.