Effect of Aripiprazole on Cognition in the Treatment of Patients with Schizophrenia

Riedel, Michael; Spellmann, Ilja; Schennach-Wolff, Rebecca; Musil, Richard; Dehning, Sandra; Cerovecki, Anja; Opgen-Rhein, M.; Matz, Jørgen; Seemüller, Florian; Obermeier, Michael; Severus, Emanuel; Engel, Rolf R.; Müller, Norbert; Möller, H.-J.

doi:10.1055/s-0029-1239539

Cited by 40 publications

(34 citation statements)

References 29 publications

(32 reference statements)

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“…Treatment with aripiprazole did not significantly improve visual learning and memory in the study by Riedel et al (39). Tandospirone, which like aripiprazole has serotonin 5-HT 1a agonistic properties, also did not significantly enhance visual learning and memory in the study of Sumiyoshi et al (38).…”

Section: Visual Learning and Memorymentioning

confidence: 80%

“…Moreover, aripiprazole added to atypical antipsychotics did not improve verbal learning and memory in a trial by Yasui-Furukori et al (42). This discrepancy in findings could be due to practice effects in the studies of Riedel et al (39) and Bervoets et al (40), since both studies did not include a control group and did not correct for possible practice effects. Furthermore, different tasks were used which makes it difficult to directly compare the results.…”

Section: Verbal Learning and Memorymentioning

confidence: 93%

“…Sumiyoshi et al (38) found a significant improvement on verbal memory after adjunctive tandospirone (a 5-HT 1a agonist) treatment compared to patients who did not receive adjunctive tandospirone. Riedel et al (39) and Bervoets et al (40) both found a significant improvement in verbal memory in patients treated with aripiprazole, an atypical antipsychotic drug with partial D 2 agonistic and antagonistic and 5-HT 2a antagonistic properties in addition to partial agonistic activity at the 5-HT 1a receptors. However, this is contradicted by Suzuki et al (41) who compared the effects of aripiprazole, olanzapine, and perospirone on verbal memory.…”

Section: Verbal Learning and Memorymentioning

confidence: 99%

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Pharmacological Interventions for the MATRICS Cognitive Domains in Schizophrenia: What’s the Evidence?

et al. 2013

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Schizophrenia is a disabling, chronic psychiatric disorder with a prevalence rate of 0.5–1% in the general population. Symptoms include positive (e.g., delusions, hallucinations), negative (e.g., blunted affect, social withdrawal), as well as cognitive symptoms (e.g., memory and attention problems). Although 75–85% of patients with schizophrenia report cognitive impairments, the underlying neuropharmacological mechanisms are not well understood and currently no effective treatment is available for these impairments. This has led to the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative, which established seven cognitive domains that are fundamentally impaired in schizophrenia. These domains include verbal learning and memory, visual learning and memory, working memory, attention and vigilance, processing speed, reasoning and problem solving, and social cognition. Recently, a growing number of studies have been conducted trying to identify the underlying neuropharmacological mechanisms of cognitive impairments in schizophrenia patients. Specific cognitive impairments seem to arise from different underlying neuropharmacological mechanisms. However, most review articles describe cognition in general and an overview of the mechanisms involved in these seven separate cognitive domains is currently lacking. Therefore, we reviewed the underlying neuropharmacological mechanisms focusing on the domains as established by the MATRICS initiative which are considered most crucial in schizophrenia.

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Section: Visual Learning and Memorymentioning

confidence: 80%

Section: Verbal Learning and Memorymentioning

confidence: 93%

Section: Verbal Learning and Memorymentioning

confidence: 99%

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Pharmacological Interventions for the MATRICS Cognitive Domains in Schizophrenia: What’s the Evidence?

et al. 2013

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“…Desta forma, alguns estudos comparando APG e ASG vêm demonstrando que os atípicos são mais efetivos em uma série de domínios cognitivos, incluindo atenção, funções executivas e fluência verbal (Keefe et al, 1999;Meltzer e McGurk, 1999;Woodward, 2005;Burton, 2006;Riedel et al, 2010).…”

Section: Efeito Da Medicação No Déficit Cognitivounclassified

“…Apesar dos dados inconclusivos na literatura a respeito do efeito dos antipsicóticos na cognição de pacientes com esquizofrenia, o presente estudo optou por padronizar e selecionar pacientes que tomassem apenas ASG, já que existem alguns dados apontando para uma superioridade dos atípicos em uma série de domínios cognitivos, como as funcões executivas (Keefe et al, 1999, Meltzer e McGurk, 1999Woodward, 2005;Burton, 2006;Riedel et al, 2010).…”

Section: Tabela 23 -Medidas Sintomatológicas Relacionadas à Contrataçãounclassified

Reabilitação vocacional e suas implicações no funcionamento cognitivo de pacientes esquizofrênicos

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confiança em meu trabalho e por me incentivar a trilhar os caminhos da pesquisa científica.Agradeço a equipe do Programa ReAção, em especial a assistente social Lais Aun Machado, que acolheu os pacientes e os ajudou a superar os medos e dificuldades, com muito carinho e dedicação tornou este projeto possível.Aos meus pais, Daniel e Cecília, por seu amor incondicional, por todo o esforço que fizeram para que eu pudesse estudar e por todo o incentivo para que eu alcançasse os objetivos mais distantes.A minha irmã Cibelle, por ser mais que uma irmã, uma companheira na jornada da vida, um modelo e uma amiga.Ao meu cunhado Thiago por seu interesse e apoio.As minhas avós Luiza e Zenaide, por acreditarem em mim e por terem sempre uma palavra de conforto nos momentos mais estressantes. Agradeço também por todas as orações.Ao meu namorado Daniel, que esteve ao meu lado todo o tempo, tendo sido sempre compreensivo com minhas ausências e impaciências, pelo seu interesse e por toda a ajuda.A todos os meus amigos por sua compreensão e apoio nos momentos de maior estresse e sobrecarga.A FAPESP pelo apoio financeiro desta dissertação. NORMATIZAÇÃO ADOTADAEsta dissertação está de acordo com as seguintes normas em vigor no momento desta

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Altered hippocampal centrality and dynamic anatomical covariance of intracortical microstructure in first episode psychosis

et al. 2020

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Hippocampal circuitry has been posited to be fundamental to positive symptoms in psychosis, but its contributions to other factors important for outcome remains unclear. We hypothesized that longitudinal changes in the hippocampal circuit and concomitant changes of intracortical microstructure are altered in first episode psychosis (FEP) patients and that such changes are associated with negative symptoms and verbal memory. Longitudinal brain scans (2–4 visits over 3–15 months) were acquired for 27 FEP and 29 age‐ and sex‐matched healthy controls. Quantitative T1 maps, sensitive to myelin content, were used to sample the microstructure of the hippocampal subfields and output circuitry (fimbria, alveus, fornix, mammillary bodies), and intracortical regions. Dynamic anatomical covariance in pair‐wise regional trajectories were assessed for each subject, and graph theory was used to calculate a participation coefficient metric that quantifies the similarity/divergence between hippocampal and intracortical microstructure. The mean participation coefficient of the hippocampus was significantly reduced in FEP patients compared with controls, reflecting differences in output hippocampal regions. Importantly, lower participation coefficient of the hippocampal circuit was associated with worse negative symptoms, a relationship that was mediated by changes in verbal memory. This study provides evidence for reduced hippocampal centrality in FEP and concomitant changes in intracortical anatomy. Myelin‐rich output regions of the hippocampus may be an important biological trigger in early psychosis, with cascading effects on broader cortical networks and resultant clinical profiles.

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Effect of Aripiprazole on Cognition in the Treatment of Patients with Schizophrenia

Abstract: Our results suggest that aripiprazole provides a valuable treatment option for patients with schizophrenia.

Cited by 40 publications

References 29 publications

Pharmacological Interventions for the MATRICS Cognitive Domains in Schizophrenia: What’s the Evidence?

Pharmacological Interventions for the MATRICS Cognitive Domains in Schizophrenia: What’s the Evidence?

Reabilitação vocacional e suas implicações no funcionamento cognitivo de pacientes esquizofrênicos

Altered hippocampal centrality and dynamic anatomical covariance of intracortical microstructure in first episode psychosis

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