Effect of Artemisia capillaris and Paecilomyces japonica on the Reduction of Hepatotoxicity and Lipid Metabolism Induced by Ethanol

Han, Eun-Kyung; Jin, Yong-Xie; Yoo, Yoon-Sook; Jung, Eui-Jin; Lee, Ji-Young; Chung, Cha-Kwon

doi:10.3746/jkfn.2009.38.8.1016

Cited by 17 publications

(3 citation statements)

References 12 publications

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“…It is noteworthy that CMα had a higher effect on reducing lipid accumulation in the liver as compared with the SM, one of the well-known hepatoprotective agents. These findings showed similarity with previous reports demonstrating fatty liver preventative effect of vegetable worms (Koh and Choi 2003;Han et al 2009). In addition, Guo et al showed that cordycepin markedly decreased the proportion of lipid droplets in the liver by Oil-Red O stain, thus suggesting that it plays a role in preventing lipid accumulation in the liver (Guo et al 2010).…”

Section: Discussionsupporting

confidence: 91%

“…According to Koh and Choi, there was a significant decrease in serum TG levels after treatment of 3% PJ in high-fat feeding rats (Koh and Choi 2003). Moreover, Han et al also reported that a significant decrease in serum TG levels was identified after treatment with 6% PJ (Han et al 2009). Furthermore, most of the studies in this series have reported the serum TC levels is increased due to heavy alcohol consumption, and disruption of cholesterol metabolism (Saini et al 2019;El-Tantawy and Temraz 2019).…”

Section: Discussionmentioning

confidence: 58%

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Anti-oxidant and anti-hyperlipidemic effects of cordycepin-rich Cordyceps militaris in a Sprague–Dawley rat model of alcohol-induced hyperlipidemia and oxidative stress

Ahn

Cho

2020

Bioresour. Bioprocess.

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Hyperlipidemia is involved in serious cardiovascular disease, however, synthetic drugs to reduce lipid contents in blood stream have been found to induce serious side effects. In the current study, we compared anti-oxidant and anti-hyperlipidemic effect of Paecilomyces japonica (PJ), Cordyceps militaris (CM) and cordycepin-rich Cordyceps militaris (CMα) in rats induced alcoholic hyperlipidemia (AIH) and oxidative stress. The experimental groups were divided in N (water), C (30% alcohol), PJ (30% alcohol + 3% PJ powder), CM (30% alcohol + 3% CM powder), CMα (30% alcohol + 3% CMα powder) and SM [30% alcohol + 0.1% silymarin (SM)]. Compared to C group, supplementation of PJ, CM, CMα and SM slightly alleviated the increased weight ratio of liver and kidney in the alcohol-treated rats. In addition, a significant or slight reduction was identified in total lipid, total cholesterol and HDL-cholesterol levels in the rats receiving PJ, CM and CMα as compared with C group. Administration of PJ, CM and CMα also blocked alcohol-induced lipid peroxidation via a decrease of malondialdehyde (MDA), and activated anti-oxidant enzyme, glutathione (GSH), in serum and various organ tissues. Overall, cordycepin-rich CMα showed highest anti-oxidant and anti-hyperlipidemia effect under chronic alcoholic damage. Our results indicate that CMα might be useful in inhibiting the oxidation and hyperlipidemia in alcohol-induced hepatic disease possibly because of potential anti-oxidative and anti-hyperlipidemic activities of cordycepin.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 58%

Anti-oxidant and anti-hyperlipidemic effects of cordycepin-rich Cordyceps militaris in a Sprague–Dawley rat model of alcohol-induced hyperlipidemia and oxidative stress

Ahn

Cho

2020

Bioresour. Bioprocess.

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“…Therefore, LDL-cholesterol is considered injurious, while HDL-cholesterol is beneficial to human health. Han et al (2009) reported that extracts from some plants, such as wormwood, decreased the total cholesterol and triglyceride concentrations in the plasma of rats, which was attributed to the phe-nols, terpenoids, and dietary fibre in wormwood. Extracts from green tea also arrested cholesterol biosynthesis and increased faecal fat due to suppressed lipid absorption by suppressed micelles in the small intestine (Ikeda 2008).…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary addition of wormwood on growth performance, blood characteristics and meat quality in growing-fattening pigs

Chu¹,

Park²

2022

CZECH J ANIM SCI

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This study investigated the effects of the dietary addition of wormwood (Artemisia montana Pampan) on growth performance, blood characteristics, carcass traits, and meat quality in growing-fattening pigs. One hundred eighty crossed pigs (Landrace × Yorkshire × Duroc), weighing approximately 70 kg, were divided into four groups of 15 head (eight barrows and seven gilts) per pen, and the experiment was replicated thrice. The basal diet (C) was supplemented with 0.5% (T1), 1.0% (T2), and 1.5% (T3) of dried powdered wormwood, and the pigs were fed an experimental diet for six weeks. The average daily weight gain and feed efficiency were significantly higher (P < 0.05) in treatments than in C. On the contrary, the total cholesterol concentration was significantly lower (P < 0.05) in treatments than in C. Additionally, the high-density lipoprotein cholesterol concentration was significantly higher (P < 0.05), and the carcass grade was better (P < 0.05) in the treatments than in C. The ether extract content of the longissimus dorsi (LD) muscle was lower (P < 0.05) in T2 and T3 than that in C. In contrast, the unsaturated fatty acid (USFA) composition in LD muscle was higher (P < 0.05) in the treatments than in C. Additionally, the marbling and flavour of cooked meat were better (P < 0.05) in the treatments than in C. The dietary addition of wormwood increased (P < 0.05) lightness and yellowness of the surface meat colour and decreased (P < 0.05) juiciness of the LD sensory evaluation. Therefore, the dietary addition of wormwood improved growth performance, feed efficiency, carcass grade, USFA composition, and oxidation of protein and lipids in the LD muscle of growing-fattening pigs.

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Protective effect of cordycepin-enriched Cordyceps militaris on alcoholic hepatotoxicity in Sprague–Dawley rats

Cha¹,

Ahn

Cho

et al. 2013

Food and Chemical Toxicology

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Effect of Artemisia capillaris and Paecilomyces japonica on the Reduction of Hepatotoxicity and Lipid Metabolism Induced by Ethanol

Cited by 17 publications

References 12 publications

Anti-oxidant and anti-hyperlipidemic effects of cordycepin-rich Cordyceps militaris in a Sprague–Dawley rat model of alcohol-induced hyperlipidemia and oxidative stress

Anti-oxidant and anti-hyperlipidemic effects of cordycepin-rich Cordyceps militaris in a Sprague–Dawley rat model of alcohol-induced hyperlipidemia and oxidative stress

Effects of dietary addition of wormwood on growth performance, blood characteristics and meat quality in growing-fattening pigs

Protective effect of cordycepin-enriched Cordyceps militaris on alcoholic hepatotoxicity in Sprague–Dawley rats

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