No abstract

This study was conducted to investigate the effects of Vaccinium uliginosum L. (bilberry) on chemically induced diabetes and hypercholesterolemia. Sprague Dawley (SD) rats were divided into six groups, control (CON), bilberry added group (CBB), streptozotocin (STZ)-induced diabetic group (STZ), STZ and bilberry added group (SBB), high fat fed group (HFF) and high fat and bilberry added group (HFB). Diabetes was chemically induced by intravenous injection of 45 mg/kg body weight STZ in citrate buffer (pH 4.5). Serum triglycerides decreased significantly (p<0.05) in the STZ group that was fed bilberry. Additionally, the athrogenic index (AI) decreased significantly (p<0.05) when compared to the STZ group, while the liver triglycerides tended to decrease in the STZ group. HDL-cholesterol also increased significantly in response to bilberry. When compared to the STZ group, steady attenuation of the blood glucose level was observed upon fasting, 15 min, 30 min, 60 min and 120 min after oral glucose administration. The blood glucose level in the bilberry fed group decreased by 24% when compared to STZ group, while the superoxide dismutase (SOD) became significantly higher (p<0.05) in the STZ group when compared to the CON group. Overall, the results of this study suggest that bilberry stimulates lipid metabolism in both the serum and liver and has a positive effect on glucose metabolism in chemically induced diabetic rats.증을 감소시킨다고 보고되고 있다(3). 최근 당뇨환자의 약물 복용에 따른 부작용을 줄이기 위하여 식용 및 약용으로 민간 요법으로 사용하던 식물에 대한 연구가 활발히 이루어지고 있다.들쭉(bilberry)은 주로 북한의 백두산 고산지대, 남한에서 는 설악산, 오대산을 비롯한 강원도 고산지대에서 자생하고 있는 야생식물(4)로 예부터 한방에서 강정, 강장, 혈당저하, 모세혈관 강화, 야맹증 및 백내장 악화방지, 괴혈병의 치료, 혈전용해제 등의 약용으로 다양하게 사용하였으며, 최근에 는 약리작용에 대한 연구도 활발하게 이루어져 항산화 및 항종양활성(5-7), 기억력 증진효과(8) 등에 관한 연구가 보 고되고 있다.들쭉은 ethyl acetate 분획에서 항산화활성이 강한 5개의 단일 compound인 myricetin, quercetin, rutin, hyperin, isoquercetin 등이 밝혀진 바 있다(9). 또한 다양한 생리활성 물질 중 catechin, tannin이 2∼10%로 특히 풍부하며 myrtillin, malvidin 등의 anthocyanocide 및 quercitrin, hyperoside 등의 플라보노이드 유도체를 함유하고 있다(10).

No abstract

This study was conducted to examine antioxidative and physiological activities of water extracts from different parts (flower, leaf, root, and the whole plant) of Taraxacum officinale. The water extracts from different parts were measured to obtain total flavonoids content, total polyphenol content, electron donating ability, SOD-like activity, nitrite-scavenging ability and tyrosinase inhibition effects. Total flavonoids and total polyphenol contents in flower extract were 32.91 mg/g and 49.31 mg/g, respectively, which were much higher than those of any other parts. The electron donating abilities of flower, leaf, the whole plant, and root extracts were 87.07%, 87.66%, 81.06% and 66.20%, respectively at a concentration of 1 mg/mL. The activities increased in a dose-dependent manner. The SOD-like activity of water extracts from different parts showed 9.07～10.97% at a concentration of 1 mg/mL. The nitrite-scavenging abilities of flower and leaf extracts measured at pH 1.2 were 36.34% and 38.16%, respectively at a concentration of 1 mg/mL. Tyrosinase inhibition activity of the leaf extract at a concentration of 1 mg/mL was the highest (34.19%) and that of the whole plant and root extracts was shown to be more than 20%. These results suggest that water extracts from different parts of Taraxacum officinale could be used as an antioxidative functional food source.

No abstract