Effect of Arthroscopic Lavage on Systemic and Synovial Fluid Serum Amyloid A in Healthy Horses

Sanchez-Teran, A.F.; Bracamonte, José L.; Hendrick, S.; Burguess, Hilary J.; Duke‐Novakovski, Tanya; Schott, Monica; Hoff, Brent; Rubio‐Martínez, Luis M.

doi:10.1111/vsu.12439

Cited by 21 publications

(37 citation statements)

References 23 publications

(90 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Jacobsen et al [27] reported slightly increased plasma SAA values up to 5 days after arthroscopy (up to 100 mg/L), however these levels remain much lower than in the cases of the present study [26]. Sanchez-Teran et al [31, 32] recently suggested in their study that in healthy adult horses neither arthroscopic lavage nor through-and-through joint lavage with needles influenced plasma SAA concentrations 48–120 h after surgery. Moreover, Pollock et al [26] described that healthy horses undergoing an elective surgery responded similar to surgical trauma than horses with elevated plasma SAA concentrations undergoing emergency surgery.…”

Section: Discussioncontrasting

confidence: 60%

Course of serum amyloid A (SAA) plasma concentrations in horses undergoing surgery for injuries penetrating synovial structures, an observational clinical study

2017

View full text Add to dashboard Cite

BackgroundInjuries penetrating synovial structures are common in equine practice and often result in septic synovitis. Significantly increased plasma levels of serum amyloid A (SAA) have been found in various infectious conditions in horses including wounds and septic arthritis. Plasma SAA levels were found to decrease rapidly once the infectious stimulus was eliminated. The purpose of the current study was to investigate the usefulness of serial measurements of plasma SAA as a monitoring tool for the response to treatment of horses presented with injuries penetrating synovial structures. In the current study plasma SAA concentrations were measured every 48 hours (h) during the course of treatment.ResultsA total of 19 horses with a wound penetrating a synovial structure were included in the current study. Horses in Group 1 (n = 12) (injuries older than 24 h) only needed one surgical intervention. Patients in this group had significantly lower median plasma SAA levels (P = 0.001) between 48 h (median 776 mg/L) and 96 h (median 202 mg/L) after surgery. A significant decrease (P = 0.004) in plasma SAA levels was also observed between 96 h after surgery (median 270 mg/L) and 6 days (d) after surgery (median 3 mg/L). Four horses (Group 2) required more than one surgical intervention. In contrast to Group 1 patients in Group 2 had either very high initial plasma concentrations (3378 mg/L), an increase or persistently high concentrations of plasma SAA after the first surgery (median 2525 mg/L). A small group of patients (n = 3) (Group 3) were admitted less than 24 h after sustaining a wound. In this group low SAA values at admission (median 23 mg/L) and peak concentrations at 48 h after surgery (median 1016 mg/L) were observed followed by a decrease in plasma SAA concentration over time.ConclusionsA decrease in plasma SAA concentrations between two consecutive time points could be associated with positive response to treatment in the current study. Therefore, serial measurements of plasma SAA could potentially be used as an additional inexpensive, quick and easy tool for monitoring the treatment response in otherwise healthy horses presented with injuries penetrating synovial structures. However further studies will be necessary to ascertain its clinical utility.

show abstract

Section: Discussioncontrasting

confidence: 60%

Course of serum amyloid A (SAA) plasma concentrations in horses undergoing surgery for injuries penetrating synovial structures, an observational clinical study

2017

View full text Add to dashboard Cite

show abstract

“…68,69 Additionally, more recent studies have found that repeated arthroscopy and repeated through-and-through joint lavage also do not affect synovial or serum SAA concentrations, whereas the nucleated cell count and total protein are increased following these procedures alone. 70,71 Although most of the SAA found within synovial fluid may be an ultrafiltrate from plasma, a jointspecific isoform of SAA is produced by synoviocytes. 72 As in other diseases, bacterial infection of joints and other synovial structures seems to be the most potent stimulant of SAA production.…”

Section: Serum Amyloid a And Diseases Of Equine Joints And Synovial Smentioning

confidence: 99%

Equine Inflammatory Markers in the Twenty-First Century

Long¹,

Nolen-Walston²

2020

Veterinary Clinics of North America: Equine Practice

View full text Add to dashboard Cite

“…Intra‐articular injection of amikacin and repeat arthrocenteses of normal joints and tendon sheaths resulted in mild increases in synovial nucleated cell count, total protein, and percentage of neutrophils . However, SAA did not increase after arthroscopic lavage on healthy horses …”

Section: Introductionmentioning

confidence: 97%

“…Unfortunately, these tests are not readily available in clinical practice. As SAA did not increase after arthroscopic lavage in healthy horses, this test seems a good candidate to monitor septic arthritis, but further studies are needed …”

Section: Introductionmentioning

confidence: 99%

“…Synovial l ‐lactate has been proposed as a diagnostic tool, and synovial serum amyloid A (SAA) is also increased in horses with septic arthritis, as well as after intra‐articular injection of lipopolysaccharide . Synovial nucleated cell count, total protein, and percentage of neutrophils were significantly increased after arthroscopic lavage in healthy horses . Intra‐articular injection of amikacin and repeat arthrocenteses of normal joints and tendon sheaths resulted in mild increases in synovial nucleated cell count, total protein, and percentage of neutrophils .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of arthroscopic lavage and repeated intra‐articular administrations of antibiotic in adult horses and foals with septic arthritis

Cousty¹,

Stack

Tricaud³

et al. 2017

Veterinary Surgery

View full text Add to dashboard Cite

show abstract

Effect of Arthroscopic Lavage on Systemic and Synovial Fluid Serum Amyloid A in Healthy Horses

Cited by 21 publications

References 23 publications

Course of serum amyloid A (SAA) plasma concentrations in horses undergoing surgery for injuries penetrating synovial structures, an observational clinical study

Course of serum amyloid A (SAA) plasma concentrations in horses undergoing surgery for injuries penetrating synovial structures, an observational clinical study

Equine Inflammatory Markers in the Twenty-First Century

Effect of arthroscopic lavage and repeated intra‐articular administrations of antibiotic in adult horses and foals with septic arthritis

Contact Info

Product

Resources

About