Effect of aspirin treatment in streptozotocin-induced type 2 diabetic rats

Abstract

In the present study, we aimed to investigate the role of aspirin in preventing type 2 diabetes in rats. At 5 days old, rat pups were divided into four groups. Group I pups received citrate buffer solution and served as control; group II was treated only with streptozotocin (80 mg/kg i.p.) and served as the diabetic control; groups III and IV were treated with aspirin (10 mg/kg/day p.o.) for 1 and 2 months, respectively, after streptozotocin treatment and served as treated groups. During weeks 8 and 10, blood samples were collected from all animals and fasting blood sugar, fasting insulin, insulin resistance and insulin sensitivity were determined. Treatment of rat pups with aspirin for 1 and 2 months after streptozotocin injection produced a significant (P < 0.001) reduction in fasting blood glucose and insulin resistance levels and elevation of fasting insulin and insulin sensitivity compared with the diabetic control pups. The results of the present study suggest that aspirin treatment prevents the development of type 2 diabetes by reducing insulin resistance and elevating fasting insulin and insulin sensitivity. It also seems to protect the pancreas from damage caused by streptozotocin and maintains glucose levels near normal in diabetic rats.

Carbohydrate Metabolism in Diabetic Rat’s Heart – The Effects of Acetylsalicylic Acid and Heat Preconditioning as HSP70 Inducers

“…According to Coe et al (36), aspirin therapy reduces diabetic mouse nonfasting blood glucose levels, has an ability to stimulate insulin and glucagon secretion and to provide improved glucose tolerance in control animals. However, according to Martha et al (37) aspirin pretreatment (10 mg/kg/day for one and two months) most obviously protect the pancreas from STZ-damage and regulates glucose levels in diabetic rats. Moreover, they found increased insulin sensitivity and reduced insulin resistance, which may indicate of involvement of IGF-1 in an insulin like pathway.…”

A possible Role of Salicylates in Diabetes Type II

“…Lin and his coworkers [49] treated Sprague-Dawley (SD) rats with high fat diet for a 10-week with low dose of aspirin (5 mg/kg Bw) found that lowdose aspirin ameliorated hyperinsulinemia and hyperlipidemia, recovered activated partial thromboplastin and prothrombin time, prevent adhesion molecules expression and chemokine formation. Rat pups (neonates) that were treated with 10 mg/kg BW aspirin for one month after streptozotocin administration showed significant reduction in blood glucose levels and insulin resistance and significant improvement in insulin levels and insulin sensitivity [50].…”