Effect of aswagandha, ginger and mulberry on hyperglycemia and hyperlipidemia

Andallu, B.; Radhika, B; Suryakantham, Velega

doi:10.1023/b:qual.0000040352.23559.04

Cited by 57 publications

(36 citation statements)

References 10 publications

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“…In addition, few studies have investigated the effects of ginger in diabetic patients. Andallu et al (17) indicated that daily administration of 3 g of ginger to diabetic patients with hypercholesterolemia for 3 months significantly decreased serum triglyceride concentrations. Mahluji et al (16) showed that serum triglyceride concentration reduced significantly after a 2-month supplementation of diabetic patients with 2 g/day ginger.…”

Section: Resultsmentioning

confidence: 99%

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Effects of Ginger on Serum Lipids and Lipoproteins in Peritoneal Dialysis Patients: A Randomized Controlled Trial

et al. 2016

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♦ Background: In peritoneal dialysis (PD) patients, one of the major risk factors for cardiovascular disease is lipid abnormalities. This study was designed to investigate the effects of ginger supplementation on serum lipids and lipoproteins in PD patients. ♦ Methods: In this randomized, double-blind, placebo-controlled trial, 36 PD patients were randomly assigned to either the ginger or the placebo group. The patients in the ginger group received 1,000 mg ginger daily for 10 weeks, while the placebo group received corresponding placebos. At baseline and at the end of week 10, 7 mL of blood were obtained from each patient after a 12-to 14-hour fast, and serum concentrations of triglyceride, total cholesterol, low density lipoprotein-cholesterol (LDL-C), high density lipoproteincholesterol (HDL-C), and lipoprotein (a) [Lp (a)] were measured. ♦ Results: Serum triglyceride concentration decreased significantly up to 15% in the ginger group at the end of week 10 compared with baseline (p < 0.01), and the reduction was significant in comparison with the placebo group (p < 0.05). There were no significant differences between the 2 groups in mean changes of serum total cholesterol, LDL-C, HDL-C, and Lp (a). ♦ Conclusion: This study indicates that daily administration of 1,000 mg ginger reduces serum triglyceride concentration, which is a risk factor for cardiovascular disease, in PD patients.

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Section: Resultsmentioning

confidence: 99%

“…Some studies have shown that ginger consumption could reduce serum triglyceride, total cholesterol, and LDL-C in patients with diabetes type 2 (15)(16)(17). According to the literature, such studies have not been performed on PD patients.…”

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confidence: 99%

Effects of Ginger on Serum Lipids and Lipoproteins in Peritoneal Dialysis Patients: A Randomized Controlled Trial

et al. 2016

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“…In the case of ginger extract the limited clinical studies done were often contradictory and difficult to interpret. In one study after consumption of 3 g of dry ginger powder in divided dose for 30 days, significant reduction in blood glucose, triglyceride, total cholesterol, LDL, and VLDL cholesterol was observed in diabetic patients [100]. A number of new clinical studies have been published recently.…”

Section: Further Clinical Studies On Ginger Are Neededmentioning

confidence: 99%

Zingiber officinale(Ginger): A Future Outlook on Its Potential in Prevention and Treatment of Diabetes and Prediabetic States

Roufogalis

2014

New Journal of Science

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Diabetes is reaching pandemic levels in both developing and developed countries and requires safe, affordable, and effective therapies. This report summarises work in our laboratory on the effects of Zingiber officinale (ginger) and its components in diabetes models and provides a future outlook on the potential for their use in type 2 diabetes. A high fat diet rat model showed modulation of body weight gain and normalisation of glucose and lipid metabolic disturbances, with reduction of insulin resistance in a high fat-high carbohydrate diet model. Ginger extract inhibits enhanced NF-B in liver of high fat-fed rats through inhibition of the IKK/I B /NF-B classical pathway. The major active component (S) -[6]-gingerol inhibited elevated cytokines in inflamed HuH-7 cells through suppression of COX2 expression and protection against the ROS pathway. Ginger extract and gingerols enhanced glucose uptake in L6 myotubes, by enhancing translocation of GLUT4 to the surface membrane and activation of AMPK 1 through a Ca 2+ /calmodulin-dependent protein kinase kinase pathway. (S)-[6]-Gingerol also enhanced energy metabolism through marked increment of peroxisome proliferator-activated receptor-coactivator-1 (PGC-1 ) gene expression and mitochondrial content in L6 skeletal muscle cells. Future studies will require well designed clinical trials on ginger preparations of defined chemical composition.

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“…In China, the mulberry tree has been widely cultivated and the different components of the bush have been used in traditional Chinese medicine for thousands of years. Recently, the mulberry leaves, which are an important food for silkworm, have also been found to have pharmacological benefits with regards to hyperglycemia and hyperlipidemia [1][2][3] and have an antioxidant action [4]. The fruit is also an antioxidant and tonic agent [5].…”

Section: Introductionmentioning

confidence: 99%

Rapid Analysis of Morusin from <i>Ramulus mori</i> by HPLC-DAD, Its Distribution <i>in Vivo</i> and Differentiation in the Cultivated Mulberry Species

Ma¹,

Cui²,

Zhang³

2013

FNS

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The distribution and content differentiation of morusin in the cultivated species of mulberry by HPLC-DAD are described in this paper. The experimental results showed that morusin is present in all parts of the mulberry bush. The content of morusin was highest in root bark and second highest in branch bark. The difference in morusin content of 20 different species of cultivated mulberry branch bark was significant. The level of morusin was highest in the branch bark of cultivated mulberry No. 404, a tetraploid cultivar, and third in the Husang 32 cultivar of Morus multicaulis. The method used in this study for determining morusin content exhibited good repeatability (RSD 6.02%) and recovery (100.62%). Therefore, the results from this study provide reliable data, for research and development in the future, on the level and distribution of morusin in mulberry in general and the differences found between various cultivated mulberries in particular. Furthermore, the HPLC-DAD method to determine morusin content is fast and reliable and is applicable not only to mulberry bushes but also to other plants.

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Effect of aswagandha, ginger and mulberry on hyperglycemia and hyperlipidemia

Cited by 57 publications

References 10 publications

Effects of Ginger on Serum Lipids and Lipoproteins in Peritoneal Dialysis Patients: A Randomized Controlled Trial

Effects of Ginger on Serum Lipids and Lipoproteins in Peritoneal Dialysis Patients: A Randomized Controlled Trial

Zingiber officinale(Ginger): A Future Outlook on Its Potential in Prevention and Treatment of Diabetes and Prediabetic States

Rapid Analysis of Morusin from <i>Ramulus mori</i> by HPLC-DAD, Its Distribution <i>in Vivo</i> and Differentiation in the Cultivated Mulberry Species

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Effect of aswagandha, ginger and mulberry on hyperglycemia and hyperlipidemia

Cited by 57 publications

References 10 publications

Effects of Ginger on Serum Lipids and Lipoproteins in Peritoneal Dialysis Patients: A Randomized Controlled Trial

Effects of Ginger on Serum Lipids and Lipoproteins in Peritoneal Dialysis Patients: A Randomized Controlled Trial

Zingiber officinale(Ginger): A Future Outlook on Its Potential in Prevention and Treatment of Diabetes and Prediabetic States

Rapid Analysis of Morusin from &lt;i&gt;Ramulus mori&lt;/i&gt; by HPLC-DAD, Its Distribution &lt;i&gt;in Vivo&lt;/i&gt; and Differentiation in the Cultivated Mulberry Species

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Rapid Analysis of Morusin from <i>Ramulus mori</i> by HPLC-DAD, Its Distribution <i>in Vivo</i> and Differentiation in the Cultivated Mulberry Species