Effect of Atorvastatin on Progression of Sensorineural Hearing Loss and Tinnitus in the Elderly

Olzowy, Bernhard; Canis, Martin; Hempel, John Martin; Mazurek, Birgit; Suckf??ll, Markus

doi:10.1097/01.mao.0000265195.16507.08

Cited by 16 publications

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“…These findings emphases a possible relationship between tinnitus and metabolic alterations, which already was pointed by many investigations (6,9,(11)(12)(13)21), since degree of tinnitus impact seems to be influenced by diet because there was improvement on discomfort caused by tinnitus, after nutritional control.…”

Section: Discussionmentioning

confidence: 94%

“…Many authors related auditory disorders, including tinnitus, to metabolic alterations (6,(9)(10)(11)(12)(13)(14). Among the problems related to lipid metabolism, increasing levels of blood cholesterol and triglycerides have been described.…”

Section: Discussionmentioning

confidence: 99%

“…It was a double-blind study, where patients were randomly assigned to treatment with either atorvastatin or placebo. After 7 and 13 months, patients were reevaluated and it wasn´t observe significant difference between two groups, regarding hearing thresholds; however, there was a tendency of statistic significance regarding tinnitus relief on atorvastatin group, just as there was a significant decrease in cholesterol levels, suggesting influence of cholesterol above tinnitus (13).…”

Section: Discussionmentioning

confidence: 99%

“…Cholesterol can impair cochlear microcirculation by diminishing the release of the potent vasodilator (nitric oxide), as well as can have a direct action at the outer hair cell membrane, diminishing its motility probably because of increased stiffness caused by integration of cholesterol molecules into the lateral wall membrane, impairing normal functioning of inner ear (13).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, modifications on blood flow or metabolites may cause damage in normal functioning of inner ear, bringing adverse consequences to auditory system. Many studies related these metabolic alterations with auditory disorders, including tinnitus (6,(9)(10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

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Sensação subjetiva do zumbido pré e pós intervenção nutricional em alterações metabólicas

Almeida¹,

Samelli

Mecca

et al. 2009

Pró-Fono R. Atual. Cient.

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Background: different etiologies are related to tinnitus including metabolic disorders (blood glucose and lipids). Aim: the aim of this study was compare tinnitus severity by self-report measures pre and post nutritional intervention, using the Tinnitus Handicap Inventory. Method: participants of this study were twenty one male and female subjects, with ages ranging from 40 to 82 years. Inclusion criteria involved the presence of tinnitus and metabolic disorder diagnosed by laboratory exams. All subjects were submitted to a nutritional intervention program. Audiological evaluation and the Tinnitus Handicap Inventory were applied pre and post intervention. Results: when comparing the presence of tinnitus pre and post intervention, data analysis indicates statistical difference concerning tinnitus sensation -71.5% of the individuals referred less impact of tinnitus in daily activities. Conclusion: an important difference was observed concerning tinnitus influence in subject's life by self-report measures. A direct relation between tinnitus and metabolic disorders in cases related with this symptom was verified. Key Words: Tinnitus; Hyperglycemia; Hypertriglyceridemia; Hypercholesterolemia. ResumoTema: diferentes etiologias estão relacionadas com a presença de zumbido, incluindo doenças metabólicas (glicêmicas e lipídicas). Objetivo: comparar o grau de severidade do zumbido por meio de medidas de autoanálise em sujeitos com alterações metabólicas pré e pós-intervenção nutricional, utilizando o Questionário de Gravidade do Zumbido. Método: vinte e um sujeitos, homens e mulheres, com idade entre 40 e 82 anos, participaram deste estudo. Critérios de inclusão abrangeram a presença de zumbido e de alteração metabólica diagnosticada por meio de exames laboratoriais. Todos os sujeitos foram submetidos a um programa de intervenção nutricional. A avaliação audiológia e o questionário de gravidade de zumbido foram aplicados pré e pós-intervenção. Resultados: comparando os resultados pré e pós-intervenção os dados mostram uma diferença estatisticamente significante com relação à sensação do zumbido em 71,5% dos sujeitos, os quais referiram menor impacto do zumbido nas atividades diárias. Conclusão: uma importante diferença foi observada com relação à influência do zumbido na vida do sujeito quando utilizadas as medidas de autoanálise. Verificou-se uma relação direta entre zumbido e alterações metabólicas em casos relacionados a estes sintomas.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sensação subjetiva do zumbido pré e pós intervenção nutricional em alterações metabólicas

Almeida¹,

Samelli

Mecca

et al. 2009

Pró-Fono R. Atual. Cient.

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Irreversible Atorvastatin‐Associated Hearing Loss

et al. 2012

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Drug-associated ototoxicity is a potentially irreversible adverse event. Among the several 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) available in the United States, only atorvastatin is associated with tinnitus, but none are associated with any forms of hearing loss. A search of the published literature (1950-August 2011) revealed no published case reports of ototoxicity associated with statins. To our knowledge, we describe the first case of progressive, irreversible hearing loss in a 32-year-old man 18 months after starting atorvastatin therapy. He began taking atorvastatin 20 mg every evening for treatment of hypercholesterolemia. Six months later, he complained of occasional episodes of tinnitus, which resolved spontaneously. An audiogram was obtained and was normal. By 18 months, the tinnitus became continuous. Another audiogram revealed bilateral "cookie-bite" middle-frequency hearing loss. Atorvastatin was immediately discontinued, and the patient was fitted with hearing aids. Four years after drug discontinuation, his hearing loss had neither progressed nor regressed. Use of the Naranjo adverse drug reaction probability scale indicated a possible (score of 2) temporal and causal relationship between the patient's hearing loss and atorvastatin. Causes of "cookie-bite" hearing loss include chronic exposure to loud noises, presbycusis, genetic predisposition, and drugs. The manufacturer of atorvastatin has received three unpublished cases of deafness, but claims that causal relationships were not established. Despite these claims by the manufacturer, based on this case report, we recommend that clinicians and patients be aware of the risk of atorvastatin-associated tinnitus and permanent hearing loss. Further research is needed to better understand the mechanism and frequency of this adverse event.

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Tinnitus treatment: Are drugs effective?

Pyykkö

Zou

Kentala

et al. 2008

Audiological Medicine

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This work evaluates trials on drug treatment of tinnitus. Tinnitus is a subjective complaint and there are no objective outcome measures. The rationale of treating tinnitus is based on two major therapeutic models: 1) cochlear origin of tinnitus in that tinnitus is alleviated by cochlear mechanisms reducing the cytotoxicity induced by the metabolic stress, influencing neural transmission and restoring the cochlear homeostasis. 2) central origin of tinnitus that involves similar mechanisms to neuropathic pain. In controlled studies there are no convincing results that any treatment will be beneficial for tinnitus. There are some exceptions with drugs that antagonize neurotransmission in glutaminergic receptors, and also possibly melatonin when sleep disorders are associated with tinnitus. The central neurotransmitter agonists and antagonists seem not to be effective. Finally, novel nano-technological advances in targeted drug carrier technology that can administer growth factors and gene machinery may be useful in future treatment of tinnitus.

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Effect of Atorvastatin on Progression of Sensorineural Hearing Loss and Tinnitus in the Elderly

Cited by 16 publications

References 0 publications

Sensação subjetiva do zumbido pré e pós intervenção nutricional em alterações metabólicas

Sensação subjetiva do zumbido pré e pós intervenção nutricional em alterações metabólicas

Irreversible Atorvastatin‐Associated Hearing Loss

Tinnitus treatment: Are drugs effective?

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