Effect of auditory cortex lesions on the discrimination of frequency‐modulated tones in rats

Rybalko, Natalia; Šuta, Daniel; Nwabueze-Ogbo, Fidel; Syka, Josef

doi:10.1111/j.1460-9568.2006.04688.x

Cited by 69 publications

(62 citation statements)

References 29 publications

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“…This AC asymmetry has recently been confirmed in rats (43). In human functional (f)MRI experiments, we found that the categorization of direction of FM stimuli produced dominant blood-oxygen leveldependent (BOLD) activation of right AC, but categorization of their duration resulted in activation of left AC (44).…”

mentioning

confidence: 70%

Global versus local processing of frequency-modulated tones in gerbils: An animal model of lateralized auditory cortex functions

Wetzel

Ohl

Scheich

2008

Proc. Natl. Acad. Sci. U.S.A.

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Hemispheric asymmetries of speech and music processing might arise from more basic specializations of left and right auditory cortex (AC). It is not clear, however, whether such asymmetries are unique to humans, i.e., consequences of speech and music, or whether comparable lateralized AC functions exist in nonhuman animals, as evolutionary precursors. Here, we investigated the cortical lateralization of perception of linearly frequency-modulated (FM) tones in gerbils, a rodent species with human-like lowfrequency hearing. Using a footshock-reinforced shuttle-box avoidance go/no-go procedure in a total of 178 gerbils, we found that (i) the discrimination of direction of continuous FM (rising versus falling sweeps, 250-ms duration) was impaired by right but not left AC lesions; (ii) the discrimination of direction of segmented FM (50-ms segments, 50-ms silent gaps, total duration 250 ms) was impaired by bilateral but not unilateral AC lesions; (iii) the discrimination of gap durations (10 -30 ms) in segmented FM was impaired by left but not right AC lesions. AC lesions before and after training resulted in similar effects. Together, these experiments suggest that right and left AC, even in rodents, use different strategies in analyzing FM stimuli. Thus, the right AC, by using global cues, determines the direction of continuous and segmented FM but cannot discriminate gap durations. The left AC, by using local cues, discriminates gap durations and determines FM direction only when additional segmental information is available.asymmetry ͉ lateralization ͉ rodents

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confidence: 70%

Global versus local processing of frequency-modulated tones in gerbils: An animal model of lateralized auditory cortex functions

Wetzel

Ohl

Scheich

2008

Proc. Natl. Acad. Sci. U.S.A.

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“…Behavioral studies in rodents (e.g., Wetzel et al, 1998;Rybalko et al, 2006) suggest an asymmetry in cortical processing, where the right hemisphere has dominance for discrimination of frequencymodulated tones. It is possible that our observations of 2-DG uptake in contralateral cortex are confounded by our manipulation of the left ear, such that if the right ear were manipulated, the results in left cortex may not be identical to our current findings.…”

Section: Cortical Reaction To Unilateral Hearing Lossmentioning

confidence: 99%

Consequences of unilateral hearing loss: Cortical adjustment to unilateral deprivation

Hutson¹,

Durham²,

Imig³

et al. 2008

Hearing Research

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The effect of unilateral hearing loss on 2-deoxyglucose (2-DG) uptake in the central auditory system was studied in post-natal day 21 gerbils. Three weeks following a unilateral conductive hearing loss (CHL) or cochlear ablation (CA), animals were injected with 2-DG and exposed to an alternating auditory stimulus (1 and 2 kHz tones). Uptake of 2-DG was measured in the inferior colliculus (IC), medial geniculate (MG), and auditory cortex (fields AI and AAF) of both sides of the brain in experimental animals and in anesthesia-only sham animals (SH). Significant differences in uptake, compared to SH, were found in the IC contralateral to the manipulated ear (CHL or CA) and in AAF contralateral to the CHL ear. We hypothesize that these findings may result from loss of functional inhibition in the IC contralateral to CA, but not CHL. Altered states of inhibition at the IC may affect activity in pathways ascending to auditory cortex, and ultimately activity in auditory cortex itself. Altered levels of activity in auditory cortex may explain some auditory processing deficits experienced by individuals with CHL.

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“…In fact, prior studies have pointed towards auditory cortex as critical for the discrimination of FM sweeps in many species including mice (Letzkus et al, 2011), rats (Rybalko et al, 2006), and Mongolian gerbils (Ohl et al, 1999). In bats, cortical circuits responsible for FM sweep processing, such as the FM-FM area involved in echolocation, have been implicated (Suga et al, 1983).…”

Section: Introductionmentioning

confidence: 99%

Multiscale mapping of frequency sweep rate in mouse auditory cortex

et al. 2017

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Functional organization is a key feature of the neocortex that often guides studies of sensory processing, development, and plasticity. Tonotopy, which arises from the transduction properties of the cochlea, is the most widely studied organizational feature in auditory cortex; however, in order to process complex sounds, cortical regions are likely specialized for higher order features. Here, motivated by the prevalence of frequency modulations in mouse ultrasonic vocalizations and aided by the use of a multiscale imaging approach, we uncover a functional organization across the extent of auditory cortex for the rate of frequency modulated (FM) sweeps. In particular, using two-photon Ca2+ imaging of layer 2/3 neurons, we identify a tone-insensitive region at the border of AI and AAF. This central sweep region behaves fundamentally differently from nearby neurons in AI and AII, responding preferentially to fast FM sweeps but not to tones or bandlimited noise. Together these findings define a second dimension of organization in the mouse auditory cortex for sweep rate complementary to that of tone frequency.

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Effect of auditory cortex lesions on the discrimination of frequency‐modulated tones in rats

Cited by 69 publications

References 29 publications

Global versus local processing of frequency-modulated tones in gerbils: An animal model of lateralized auditory cortex functions

Global versus local processing of frequency-modulated tones in gerbils: An animal model of lateralized auditory cortex functions

Consequences of unilateral hearing loss: Cortical adjustment to unilateral deprivation

Multiscale mapping of frequency sweep rate in mouse auditory cortex

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