Effect of autologous platelet-rich plasma in the promotion of healing of chronic ulcers

Raslan, Mohamed A.; Milad, Nader; Al-Aziz, Ahmed Abd

doi:10.18203/2349-2902.isj20175484

Cited by 6 publications

(4 citation statements)

References 17 publications

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“…Likewise, Tendas et al reported improvement in ulcers following PRP application to pressure ulcers nine times during 4 months . Raslan et al applied PRP to chronic wounds in 24 patients, including pressure ulcers, and reported a significant improvement . In a study conducted by Kakudo et al it was seen that there is a complete healing in the chronic ulcers including pressure ulcers after dressing with PRP gel.…”

Section: Discussionmentioning

confidence: 99%

Comparison of platelet‐rich plasma gel in the care of the pressure ulcers with the dressing with serum physiology in terms of healing process and dressing costs

Uçar

Çelik²

2020

International Wound Journal

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This research was carried out with the aim of comparing the effects of platelet‐rich plasma (PRP) gel and gas dressing with serum physiologic applied to stage II pressure ulcer in coccyx of patients for 2 months on healing process and dressing costs. This prospective randomised controlled experimental study was conducted with 60 patients hospitalised in the palliative care unit after surgery. The experimental group (n = 30) was dressed with platelet‐rich plasma gel. The control group (n = 30) was treated with serum physiologic dressing. At the end of the 20th observation of the patients in the experimental group, it was found that the mean scores of area, exudate, and tissue type in pressure sores decreased statistically (P < .001). In the control group, no significant difference was found between the mean PUSH score at the end of the 20th observation (P > .05). The study showed that PRP gel had a positive effect on healing of stage II pressure ulcers with platelet‐rich plasma gel dressings. In addition, when evaluated in the long term, it was concluded that platelet‐rich plasma gel is easily accessible and less costly than serum physiological dressing.

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Section: Discussionmentioning

confidence: 99%

Comparison of platelet‐rich plasma gel in the care of the pressure ulcers with the dressing with serum physiology in terms of healing process and dressing costs

Uçar

Çelik²

2020

International Wound Journal

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“…Autologous plateletderived wound-healing factors have been proposed to regulate wound healing of chronic cutaneous ulcers by promoting the formation of granulation tissue in the early healing phase. Researchers reported the usefulness of PRP in the treatment of chronic ulcers including pressure ulcer [12][13][14][15][16][17][18]. However, further studies have been suggested for consolidation of these findings [12,[16][17][18].…”

Section: Introductionmentioning

confidence: 99%

“…Researchers reported the usefulness of PRP in the treatment of chronic ulcers including pressure ulcer [12][13][14][15][16][17][18]. However, further studies have been suggested for consolidation of these findings [12,[16][17][18]. Also, most of the previous studies assessed the effect of PRP on two-dimensional characteristics, assessing the area of the ulcer and clinical improvements.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Local Autologous Platelet-Rich Plasma in the Treatment of Pressure Ulcer in Spinal Cord Injury Patients

Singh¹,

Borah²,

Khanna³

et al. 2021

Cureus

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Background: Pressure ulcer is one of the common complications occurring in spinal cord injury (SCI) patients. Platelet-rich plasma (PRP) has been found useful in the treatment of pressure ulcers in few studies. The purpose of this study was to evaluate the role of PRP in pressure ulcer healing in comparison to hydrogel dressing in SCI patients.Methods: In this randomized interventional study, 52 patients of SCI having pressure ulcers of grade III/IV were randomized into two groups of 26 each. In group A patients, hydrogel dressing was done while freshly prepared PRP was used in patients of group B. Pressure ulcers were evaluated at baseline and after three weeks and six weeks in terms of ulcer surface area, volume, Pressure Ulcer Scale for Healing (PUSH) score, histopathology, and ulcer healing parameters. Data were collected and quantitative variables were compared using unpaired t-test or Mann-Whitney test between the two groups and qualitative variables were compared using the chi-square test or Fisher's exact test. A p-value of <0.05 was considered statistically significant.Results: Baseline characteristics were comparable in both groups. There was a significant improvement in ulcers in terms of surface area, volume, and PUSH score in both the groups but it was comparable (p-value >0.05). There was a significant improvement in the PRP group as compared to the other group in terms of epithelization, granulation, and neovascularization at three and six-week follow-up.Conclusions: This study suggests that PRP is a possible and better alternative to conventional dressing methods for the treatment of pressure ulcers.

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“…Various studies have reported that PRP acts as an effective therapy for muscle injury, chronic wounds, and atrophic and contractile scars by rejuvenating skin tissue and texture (Nita et al, 2013;A Hamid et al, 2014;Raslan et al, 2017). However, other studies have shown no statistically significant difference between PRP and control groups regarding wound healing (Buchwald et al, 2008;Martinez-Zapata et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Is PRP Effective in Reducing the Scar Width of Primary Cleft Lip Repair? A Randomized Controlled Clinical Study

Refahee

Aboulhassan

Aziz

et al. 2019

The Cleft Palate-Craniofacial Journal

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Objective: To evaluate and analyze the effect of platelet-rich plasma (PRP) injection on the scar formed after unilateral complete cleft lip scar repair using a modified Millard technique. Hypothesis: An unavoidable cheiloplasty scar is a result of the wound healing process that not only influences patient self-esteem for life but also affects muscle function. Design: Blind, randomized, controlled clinical trial. Patients: From December 2016 to February 2018, 24 patients with unilateral complete cleft lip undergoing primary cheiloplasties were equally assigned to study and control groups. Intervention: All patients were treated by modified Millard cheiloplasty. In the study group, PRP was injected into the muscle and skin layers immediately after wound closure, while the control group patients were treated with no PRP injection. Outcomes Measures: Scar width was assessed after 6 months through the muscle using ultrasonography and at the skin surface via photographs. Results: Scar width showed a significant improvement in the study group. Conclusions: Injection of autologous PRP provides effective improvement of cutaneous and muscular wound healing and decreases scar tissue formation.

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Effect of autologous platelet-rich plasma in the promotion of healing of chronic ulcers

Cited by 6 publications

References 17 publications

Comparison of platelet‐rich plasma gel in the care of the pressure ulcers with the dressing with serum physiology in terms of healing process and dressing costs

Comparison of platelet‐rich plasma gel in the care of the pressure ulcers with the dressing with serum physiology in terms of healing process and dressing costs

Efficacy of Local Autologous Platelet-Rich Plasma in the Treatment of Pressure Ulcer in Spinal Cord Injury Patients

Is PRP Effective in Reducing the Scar Width of Primary Cleft Lip Repair? A Randomized Controlled Clinical Study

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