Effect of Ayurvedic Intervention as an adjunct therapy in Post COVID-19 Mucormycosis (PCM): A non-randomized parallel group study

Madikonda, Praveen kumar; Perugu, Srikanth Babu; Ramadevi, C H

doi:10.1016/j.jaim.2022.100672

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…Mucormycosis is an opportunistic angio-invasive fungal infection associated with PASC 774 . In a prospective human RCT ( n = 77), Ayurvedic therapy as an adjunct to conventional medical treatments showed significant improvement across the entire spectrum of mucormycosis in PASC patients 775 .…”

Section: Long-covid/pasc: Precision Nutrition To Reset Virus-induced ...mentioning

confidence: 99%

Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID

Naidu,

Wang,

Rao

et al. 2024

npj Sci Food

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SARS‐CoV‐2, the etiological agent of COVID-19, is devoid of any metabolic capacity; therefore, it is critical for the viral pathogen to hijack host cellular metabolic machinery for its replication and propagation. This single-stranded RNA virus with a 29.9 kb genome encodes 14 open reading frames (ORFs) and initiates a plethora of virus–host protein–protein interactions in the human body. These extensive viral protein interactions with host-specific cellular targets could trigger severe human metabolic reprogramming/dysregulation (HMRD), a rewiring of sugar-, amino acid-, lipid-, and nucleotide-metabolism(s), as well as altered or impaired bioenergetics, immune dysfunction, and redox imbalance in the body. In the infectious process, the viral pathogen hijacks two major human receptors, angiotensin-converting enzyme (ACE)-2 and/or neuropilin (NRP)-1, for initial adhesion to cell surface; then utilizes two major host proteases, TMPRSS2 and/or furin, to gain cellular entry; and finally employs an endosomal enzyme, cathepsin L (CTSL) for fusogenic release of its viral genome. The virus-induced HMRD results in 5 possible infectious outcomes: asymptomatic, mild, moderate, severe to fatal episodes; while the symptomatic acute COVID-19 condition could manifest into 3 clinical phases: (i) hypoxia and hypoxemia (Warburg effect), (ii) hyperferritinemia (‘cytokine storm’), and (iii) thrombocytosis (coagulopathy). The mean incubation period for COVID-19 onset was estimated to be 5.1 days, and most cases develop symptoms after 14 days. The mean viral clearance times were 24, 30, and 39 days for acute, severe, and ICU-admitted COVID-19 patients, respectively. However, about 25–70% of virus-free COVID-19 survivors continue to sustain virus-induced HMRD and exhibit a wide range of symptoms that are persistent, exacerbated, or new ‘onset’ clinical incidents, collectively termed as post-acute sequelae of COVID-19 (PASC) or long COVID. PASC patients experience several debilitating clinical condition(s) with >200 different and overlapping symptoms that may last for weeks to months. Chronic PASC is a cumulative outcome of at least 10 different HMRD-related pathophysiological mechanisms involving both virus-derived virulence factors and a multitude of innate host responses. Based on HMRD and virus-free clinical impairments of different human organs/systems, PASC patients can be categorized into 4 different clusters or sub-phenotypes: sub-phenotype-1 (33.8%) with cardiac and renal manifestations; sub-phenotype-2 (32.8%) with respiratory, sleep and anxiety disorders; sub-phenotype-3 (23.4%) with skeleto-muscular and nervous disorders; and sub-phenotype-4 (10.1%) with digestive and pulmonary dysfunctions. This narrative review elucidates the effects of viral hijack on host cellular machinery during SARS-CoV-2 infection, ensuing detrimental effect(s) of virus-induced HMRD on human metabolism, consequential symptomatic clinical implications, and damage to multiple organ systems; as well as chronic pathophysiological sequelae in virus-free PASC patients. We have also provided a few evidence-based, human randomized controlled trial (RCT)-tested, precision nutrients to reset HMRD for health recovery of PASC patients.

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Section: Long-covid/pasc: Precision Nutrition To Reset Virus-induced ...mentioning

confidence: 99%

Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID

Naidu,

Wang,

Rao

et al. 2024

npj Sci Food

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“…CAM telah meningkat pesat selama dua tahun pandemi terakhir karena vitamin, obat-obatan herbal, dan suplemen lainnya dapat menjadi pilihan yang hemat biaya dan aman untuk mempertahankan status kesehatan dan khususnya untuk pertahanan kekebalan yang optimal (Conti et al, 2023). Terapi herbal tidak dapat digunakan sebagai pengobatan tunggal dan harus digunakan bersama dengan pengobatan medis konvensional (Madikonda et al, 2022). Meski demikian, complementary and 6265 Fahrun Nur Rosyid, Promosi Kesehatan untuk… alternative medicine/ CAM dengan pengobatan herbal secara signifikan mengurangi gejala fisik (faktor inflamasi, aktivitas fisik, nyeri dada, dan fungsi pernapasan) dan gejala psikologis (depresi, kecemasan, stres), kualitas tidur, emosi negatif, dan kualitas hidup pada pasien COVID-19.…”

Section: B Metode Pelaksanaanunclassified

Promosi Kesehatan Untuk Meningkatkan Kualitas Hidup Pasca Menderita Infeksi Covid-19

Rosyid,

Kristinawati,

Nurcahyanto

et al. 2023

JMM

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Abstrak: Pasca COVID-19 dapat menimbulkan dampak yang signifikan pada kualitas hidup terkait kesehatan individu yang terinfeksi, yaitu memburuknya kualitas hidup mereka. Kegiatan promosi kesehatan ini bertujuan untuk meningkatkan pengetahuan masyarakat terkait pemanfaatan produk herbal habbatusauda, madu dan minyak VCO. Pengabdian kepada masyarakat ini diawali dengan melakukan pretest untuk mengetahui pengetahuan perta promosi kesehatan sebelum dilakukan edukasi. Kegiatan PkM dilanjutkan dengan penberian edukasi dan diakhiri dengan melakukan evaluasi paska dilakuakna edukasi untuk menilai pengetahuan posttest edukasi kesehatan. Pelaksanaan PkM dilakukan terhadap mitra pertama yang berjumlah 15 orang pada hari Kamis, 16 Desember 2021 dan mitra kedua yang juga berjumlah 15 orang pada hari Jum’at, 17 Desember 2021 dengan tema edukasi yang sama yaitu tentang manfaat suplemen herbal untuk meningkatkan kualitas hidup pasien paska infeksi COVID-19 dengan menurunkan atau menghilangkan gejala sisa persisten yang dialaminya. Hasil pemberian edukasi setelah dilakukan evaluasi menunjukan perubahan signifikan skor pengetahuan peserta sebelum (30%) dan setelah edukasi (66%).Abstract: Post-COVID-19 can have a significant impact on the health-related quality of life of infected individuals, namely worsening their quality of life. This health promotion activity aims to increase public knowledge regarding the use of black seed herbal products, honey and VCO oil. This community service begins with conducting a pretest to find out knowledge about health promotion before education is carried out. PkM activities continue with providing education and end with conducting a post-education evaluation to assess knowledge of the health education posttest. The implementation of PkM was carried out on the first partner, numbering 15 people, on Thursday, 16 December 2021 and the second partner, also numbering 15 people, on Friday, 17 December 2021 with the same educational theme, namely about the benefits of herbal supplements to improve the quality of life of patients. Post-COVID-19 infection by reducing or eliminating the persistent residual symptoms they experience. The results of providing education after the evaluation showed significant changes in participants' knowledge scores before (30%) and after education (66%).

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Black fungus – An emerging threat

Kumar,

Mohan,

Venkatesha

et al. 2024

JADE

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The term “black fungus” is referred to fulminating, dreadful fungus mucormycosis infection, so-called because of the black-colored necrotic areas it causes due to the black-colored colonies of the fungus, which thrives in infected tissues. Recently, in this COVID-19 pandemic, it has emerged as a new threat to the world. This article enlightens us with the predisposing factors, pathogenesis, types, clinical features, diagnostic modalities, and treatment of Mucormycosis.

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Effect of Ayurvedic Intervention as an adjunct therapy in Post COVID-19 Mucormycosis (PCM): A non-randomized parallel group study

Cited by 4 publications

References 14 publications

Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID

Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID

Promosi Kesehatan Untuk Meningkatkan Kualitas Hidup Pasca Menderita Infeksi Covid-19

Black fungus – An emerging threat

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