Effect of bajijiasu isolated from Morinda officinalis F. C. how on sexual function in male mice and its antioxidant protection of human sperm

Wu, Zeqing; Chen, Diling; Lin, Fei; Lin, Li; Shuai, Ou; Wang, Jin-Yu; Qi, Longkai; Zhang, Peng

doi:10.1016/j.jep.2015.02.016

Cited by 52 publications

(39 citation statements)

References 34 publications

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“…It was shown that pretreatment with aqueous extract from Morinda officinalis How could improve the sexual performance and increase the serum testosterone level of male rats suffering from reproductive impairment (21). This was consistent with results of another study, which exhibited that administration of oral bajijiasu, an extract from Morinda officinalis How, enhanced the sexual behavior and increased the testosterone concentration of both normal and kidney-yang-deficient mice (22). However, the underlying mechanism needs further investigation.…”

Section: Chinese Herbal Treatment For Edsupporting

confidence: 92%

Traditional Chinese medical therapy for erectile dysfunction

Li¹,

Jiang²,

Liu³

2017

Transl. Androl. Urol.

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Traditional Chinese medicine (TCM), including acupuncture and Chinese herbs, is used as an alternative therapy to increase the curative effect for erectile dysfunction (ED). A large number of studies have been conducted to investigate the effect and mechanism of TCM for treating ED. The therapeutic effect of acupuncture on ED is still controversial at present. However, some Chinese herbs exhibited satisfying outcomes and they might improve erectile function by activating nitric oxide synthase (NOS)-cyclic guanosine monophosphate (cGMP) pathway, increasing cyclic adenosine monophosphate (cAMP) expression, elevating testosterone level, reducing intracellular Ca2+ concentration, down-regulating transforming growth factor β1 (TGFβ1)/Smad2 signaling pathway, or ameliorating the oxidative stress.

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Section: Chinese Herbal Treatment For Edsupporting

confidence: 92%

Traditional Chinese medical therapy for erectile dysfunction

Li¹,

Jiang²,

Liu³

2017

Transl. Androl. Urol.

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“…The identified active ingredient of the plant, bajijiasu, was also shown to enhance the sexual behaviour of mice, improve the testosterone concentration and sperm quality, and protect the sperm DNA from damage by reactive oxygen species (Wu et al, ). Bajijiasu is suggested to possess androgenic properties, which increased the libido and physical sexual activity of mice (Lin, Lin, Xiao, Liu, & Wang, ; Wu et al, ). It was also found that water‐soluble polysaccharides extracted from M. officinalis stimulated gonadotrophin secretion via up‐regulating the kisspeptin 1‐GPR54 pathway and activation of MAPK phosphorylation.…”

Section: Morinda Officinalismentioning

confidence: 99%

Plants in the management of male infertility

Onuah

Singh

2020

Andrologia

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This review attempts to collate existing data and provide the perspectives for future studies on the effects of plants on the male gonads. For many of these medicinal plants such as Lepidium meyenii, Rupus coreanus, Tribulus terrestres, Panax ginseng, Petasites japonicas, Apium graveolens, Eurycoma longifólia, Pedalium murex, Corchorus depressus, Mucuna pruriens, Astragalus membranaceus, Nigella sativa, Crataegus monogyna, Fagara tessmannii, Phaleria macrocarpa, Anacyclus pyrethrum, Cynomorium songaricum and Morinda officinalis, the mechanism of actions of their active principles and crude extracts has been shown in both laboratory animals, in vitro, and human studies, and includes their antioxidant, anti‐inflammatory, spermatogenesis‐inducing, aphrodisiac, smooth muscle relaxing and androgenic properties. Several active chemical leads including glucosinolates, anthocyanins, protodioscin, ginsenosides, sesquiterpenes, phyto‐oestrogens, quassinoids, diosgenin, thymoquinone, proanthocyanidins and bajijiasu isolated from these plants are known to have target effects on the testis, but efforts have been limited in their application at the clinical level. There still appear to be many more extracts of medicinal plants that have not been characterised to determine the phytochemicals unique to them that have target effects on the gonads. Further, collaborative efforts at isolating pro‐drug candidates from medicinal plants for studies at the molecular, cellular and clinical level towards elucidating their mechanisms of action on the testes are therefore warranted in the light of the current male fertility crisis.

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“…e therapeutic effect on spermatozoa dysfunction of most of the traditional Chinese medicine contained in the prescription has also begun to be discovered, such as Cuscuta australis R. Br. [15], Morinda officinalis How [16], and Epimedium brevicomu Maxim [17]. After nearly 10 years of clinical observation and patient feedback, it was found that this prescription treated male oligospermia, asthenospermia, nonliquefaction of the seminiferous tubules, and other symptoms.…”

Section: Introductionmentioning

confidence: 99%

Duzhong Butiansu Prescription Improves Heat Stress‐Induced Spermatogenic Dysfunction by Regulating Sperm Formation and Heat Stress Pathway

Hou

Yuan

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Duzhong Butiansu (DZBTS) prescription contains many traditional Chinese medicines and has been shown to have a curative effect on male fertility. However, the efficacy and mechanism of DZBTS in the treatment of male infertility induced by heat stress have not been reported. The aim of the present study is to elucidate the effect and mechanism of DZBTS on spermatogenic function of a heat stress model in rats. Methods. Male Wistar rats (280–320 g) were given different doses of DZBTS (0.4853 g/kg/d or 0.9707 g/kg/d), Shengjing capsule (0.56 g/kg/d), or double distilled water for 15 days. A 43°C hot water bath for 30 minutes was used to stimulate the testis of rats. Sperm count, sperm motility, the organ index of kidney and gonadal organs, serum sex hormone levels, and serum oxidising reaction index were measured. Haematoxylin and eosin (HE) staining was used to observe the morphology of the testis and kidney. The expression of Hsp70 in testes was observed by immunofluorescence. The changes in heat stress, reproductive-related protein, and mRNA were measured by western blot assay and RT-qPCR. Results. Heat stress downregulated the levels of sex hormone (P<0.05 or P<0.01) and its receptor androgen receptor (AR) protein expression and mRNA (P<0.01) in rats. Meanwhile, heat stress downregulated the levels of CAMP-responsive element-binding (CREB1) protein and mRNA (P<0.01), which are involved with spermatogenesis. Heat stress also decreased the oxidative damage index. Furthermore, Hsp70 and the heat shock transcription factor 1 (HSF1) protein pathway and mRNA level were overactivated (P<0.05 or P<0.01). Finally, the organ coefficients of the kidney and gonadal organs of rats were decreased. The sperm concentration and motility also decreased significantly (P<0.01). DZBTS could recover these changes induced by heat stress. Conclusions. Our results for the first time have found that DZBTS can improve spermatogenesis disorder in a heat stress model in rats, which may be mainly by regulating AR, sperm regulatory protein CREB1, and the HSF/Hsp70 signaling pathway to decrease oxidative stress.

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Effect of bajijiasu isolated from Morinda officinalis F. C. how on sexual function in male mice and its antioxidant protection of human sperm

Cited by 52 publications

References 34 publications

Traditional Chinese medical therapy for erectile dysfunction

Traditional Chinese medical therapy for erectile dysfunction

Plants in the management of male infertility

Duzhong Butiansu Prescription Improves Heat Stress‐Induced Spermatogenic Dysfunction by Regulating Sperm Formation and Heat Stress Pathway

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