Effect of Barley Flour, Crude Cinnamon, and Their Combination on Glycemia, Dyslipidemia, and Adipose Tissue Hormones in Type 2 Diabetic Rats

Abstract

This study aimed to evaluate the effects of barley flour, crude cinnamon, and their combination on blood glucose, serum insulin, serum lipid profile, and serum adipose tissue hormones in streptozotocin-induced diabetic rats. Male Wistar rats (n=35) were divided into five groups: nondiabetic, diabetic, diabetic group fed 5% cinnamon, diabetic group fed 30% barley, and diabetic group fed 5% cinnamon and 30% barley. Fasting blood glucose, insulin, lipid profile, adiponectin, and leptin were measured after 8 weeks. Blood glucose significantly decreased in all treated diabetic rats compared with the diabetic group. Serum insulin and high-density lipoprotein significantly increased, while cholesterol, triglycerides, and low-density lipoprotein were significantly decreased after 8 weeks. Adiponectin significantly increased, while leptin significantly decreased with administration of either cinnamon, barley, or their combination. No significant differences were observed among the three treated groups on all parameters. A cinnamon and barley combination caused obvious improvement in insulin-positive cells of pancreatic tissue. In conclusion, consuming diets containing either cinnamon, barley, or their combination regulates blood glucose, lipid profile, and adipose tissue hormones in type 2 diabetic rats. The most effective treatment was the cinnamon and barley combination.

Maternal cinnamon extract intake during lactation leads to sex‐specific endocrine modifications in rat offspring

“…Although cinnamon has anti‐diabetogenic effects, earlier studies support the hypothesis that this effect is, at least in part, independent of adiponectin stimulation . Previously, we reported that aqueous cinnamon extract supplementation promotes a reduction in leptin serum concentration and mRNA expression in WAT, which has been corroborated in other studies . However, during lactation, this effect of cinnamon appears to be nullified.…”

“…5,16 Previously, we reported that aqueous cinnamon extract supplementation promotes a reduction in leptin serum concentration and mRNA expression in WAT, 5 which has been corroborated in other studies. 42,43 However, during lactation, this effect of cinnamon appears to be nullified. Moreover, the normal serum leptin levels were in agreement with the unchanged food intake observed in the cinnamon-supplemented dams.…”

Effects of cinnamon supplementation on body weight and composition in adults: A systematic review and meta‐analysis of controlled clinical trials

“…Furthermore, it activates transient receptor potential‐ankyrin receptor 1 (TRPA1) and genes involved in fatty acid oxidation in adipose tissue. Cinnamon might also stimulate interscapular brown adipose tissue and hyperinsulinemia, decrease serum leptin levels, regulate the expression of peroxisome proliferator‐activated receptor γ (PPARγ) and CCAAT/enhancer binding protein (C/EBPs) family, change the gut microbiota and markers of the gut barrier, and prevent adipocyte differentiation and adipogenesis (Camacho et al, ; Lee, Siaw, & Kang, ; Shatwan, Ahmed, & Badkook, ; Van Hul et al, ).…”

Therapeutic Potential of Cinnamomum Zeylanicum Extract to Mitigate Hyperglycemia

“…In a study, Shatwan et al 20 assessed the effect of cinnamon extract on feed intake of male Wistar rats. They were of the view that feed intake was significantly higher (35.99 ± 3.17 and 30.23 ± 3.58 g) in diabetic and cinnamon treated rats as compared to control (25.93 ± 1.33 g) group.…”