Effect of Bauhinia forficata extract in diabetic pregnant rats: maternal repercussions

Damasceno, Débora Cristina; Volpato, Gustavo Tadeu; Calderon, Iracema de Mattos Paranhos; Aguilar, Raul; Rudge, Marilza

doi:10.1078/0944-7113-00348

Cited by 60 publications

(61 citation statements)

References 11 publications

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“…[1][2][3] According to the World Health Organization, about 80% of the people in the world use medicinal herbs to treat and prevent diseases instead of primary medical assistance because of low prices and the ease of obtaining such medicinal plants. 4 Literature data confirm the significant effects of alternative medicine to control hyperglycemia 5,6 and lipid levels. [7][8][9] Hypercaloric diets are very common nowadays and increase the occurrence of hypercholesterolemia and low levels of high-density lipoprotein-cholesterol (HDL-c), resulting in higher risks of cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 92%

Effects ofPassiflora edulis(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Souza

Barbalho

Damasceno

et al. 2012

Journal of Medicinal Food

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The aim of this study was to evaluate the effects of Passiflora edulis f. flavicarpa Degener (yellow passion) juice on the lipid profile and oxidative stress status of Wistar rats. Adult male Wistar rats were divided in two groups (n = 8 animals per group): the control group, which received water, and the treated group, which was given P. edulis juice (1,000 mg/kg). Both groups received by gavage treatment twice a day for 28 days. The treated group showed an increased high-density lipoproteincholesterol level and decreased low-density lipoprotein-cholesterol and free fatty acid levels compared with the control group. Levels of triglycerides and and very low-density lipoprotein-cholesterol, superoxide dismutase activity, and total glutathione concentration were not statistically different between the two groups, but the thiobarbituric acid-reactive substances concentration (indicating lipid peroxidation) decreased in the treated group. These findings suggests that P. edulis juice in the experimental conditions used showed beneficial effects on lipid profile and improved lipid peroxidation in Wistar rats.

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Section: Introductionmentioning

confidence: 92%

Effects ofPassiflora edulis(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Souza

Barbalho

Damasceno

et al. 2012

Journal of Medicinal Food

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“…Rev Assoc Med Bras 2009; 55(4): 384-8 utilizing high doses of STZ during the adult life of animals 8,9,10,11 . Experimental mild diabetes (fasting glycemic level from 120 to 360 mg/dL) characterizes clinical status of type 2 Diabetes mellitus (DM2).…”

Section: Discussionmentioning

confidence: 99%

Neonatally-induced diabetes: lipid profile outcomes and oxidative stress status in adult rats

Sinzato¹,

Lima²,

Campos³

et al. 2009

Rev. Assoc. Med. Bras.

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0.05) in the n5-STZ animals when compared to control group. However n5-STZ animals showed a significant decreased HDL-cholesterol rate (p<0.05). CONCLUSION: This streptozotocin-induced diabetes model in rats caused hyperglycemia (120-360mg/dL), characterizing mild diabetes. This glycemic level led to HDL-lipoprotein alteration, which was not sufficient to impair antioxidant enzyme activities or determination of lipid peroxidation in adult life of rats. Further this experimental investigation contributed to the understanding of different results found in other models for mild/moderate diabetes induction in laboratory animals as well as to a better comprehension of the pathophysiological mechanisms of mild diabetes or hyperglycemia in humans.]]>

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“…Thus, besides its antidiabetic action, C. sicyoides has been furthermore evaluated for its anticonvulsant property in Brazil, where it is also used against epilepsy (Elisabetsky et al, 1988). In fact, in the leaves of this species has been identified the presence of α-tocopherol, a compound proved to protect against pentylenotetrazol pharmacological potency (Havsteen, 1983) and, among some of the constituents of B. forficata, most studies have examined the effects of natural flavonoids in physiological and pathological conditions of glucose metabolism, as well as in lipid peroxidation (Damasceno et al, 2004;De Sousa et al, 2004). Thus, such studies evidenced that B. forficata has significant antioxidant activity, beneficial in the prevention of diabetes complications associated with oxidative stress (Khalil et al, 2008).…”

Section: Bauhinia Forficata Link Fabaceae (Mororó)mentioning

confidence: 99%

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

Silva¹,

Melo²,

Vasconcelos³

et al. 2012

Rev. bras. farmacogn.

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Abstract:Medicinal plants have been used in traditional medicine for several thousand years all over the world. In this sense, information from Brazilian ethnic groups on folk medicine have contributed to the discovery of pharmacological activities from various plant-derived agents potentially leading to the innovative drugs. The Caatinga (semi-arid) vegetation is a highly threatened biome, covering a vast area in northeastern Brazil and has suffered from strong human influence for many decades. Many plants species found in the Caatinga have been widely used in folk medicine and for commercial manufacturing of phytotherapeutic products. Thus, the present review aims to disseminate to the scientific community some known species of medicinal plants found in the Caatinga that have been studied and analyzed in pharmacological scientific assays. Among the species that stood out for their local importance and multiplicity of uses were: Amburana cearensisand Zingiber officinalis L. (gengibre). The present study shows that several herbal constituents from Caatinga plants, whose pharmacological actions have been well characterized, may be relevant candidates for future and innovative therapeutic development.

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Effect of Bauhinia forficata extract in diabetic pregnant rats: maternal repercussions

Cited by 60 publications

References 11 publications

Effects ofPassiflora edulis(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Effects ofPassiflora edulis(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Neonatally-induced diabetes: lipid profile outcomes and oxidative stress status in adult rats

Bioactivity and potential therapeutic benefits of some medicinal plants from the Caatinga (semi-arid) vegetation of Northeast Brazil: a review of the literature

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