Effects of<i>Passiflora edulis</i>(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Souza, Maricelma da Silva Soares de; Barbalho, Sandra Maria; Damasceno, Débora Cristina; Rudge, Marilza Vieira Cunha; Campos, Kleber Eduardo de; Madi, Ana Carolina Goyos; Coelho, Bruno Ribeiro; Oliveira, Rodrigo Cesar Reis de; Melo, Rodrigo Cartaxo de; Donda, Vinícius Castrequini

doi:10.1089/jmf.2011.0056

Cited by 27 publications

(12 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…De Souza et al . () showed that the treatment of normotensive Wistar rats with Passiflora edulis juice decreased TBARS levels; however, this study did not investigate the effects of the juice on blood pressure. Furthermore, the present study found lower GSH content and higher TBARS levels in SHR compared to Wistar rats, which is consistent with other studies describing that hypertensive patients show greater oxidative stress with higher reactive species than that present in the normal oxidative stress response (Houston, ) and that the renal oxidative stress of SHR is higher than that of normotensive rats (Biswas and De Faria, ).…”

Section: Discussionmentioning

confidence: 79%

Evaluation of the Antihypertensive Properties of Yellow Passion Fruit Pulp (Passiflora edulis Sims f. flavicarpa Deg.) in Spontaneously Hypertensive Rats

Konta

Almeida

Amaral

et al. 2013

Phytotherapy Research

View full text Add to dashboard Cite

Various species of the genus Passiflora have been extensively used in traditional medicine as sedatives, anxiolytics, diuretics and analgesics. In the present study, after the identification and quantification of phytochemical compounds from yellow passion fruit pulp by liquid chromatography-photodiode array-mass spectrometry (HPLC-PDA-MS/MS), its antihypertensive effect was investigated on spontaneously hypertensive rats. Additionally, the renal function, evaluated by kidney/body weight, serum creatinine, proteinuria, urinary flow, reduced glutathione (GSH) levels and thiobarbituric acid-reactive substances (TBARS) and mutagenicity in bone marrow cells were assessed to evaluate the safety of passion fruit consumption. Yellow passion fruit pulp (5, 6 or 8 g/kg b.w.) was administered by gavage once a day for 5 consecutive days. HLPC-PDA-MS/MS analysis revealed that yellow passion fruit pulp contains phenolic compounds, ascorbic acid, carotenoids and flavonoids. The highest dose of passion fruit pulp significantly reduced the systolic blood pressure, increased the GSH levels and decreased TBARS. There were no changes in renal function parameters or the frequency of micronuclei in bone marrow cells. In conclusion, the antihypertensive effect of yellow passion fruit pulp, at least in part, might be due to the enhancement of the antioxidant status. The exact mechanisms responsible by this effect need further investigation.

show abstract

Section: Discussionmentioning

confidence: 79%

Evaluation of the Antihypertensive Properties of Yellow Passion Fruit Pulp (Passiflora edulis Sims f. flavicarpa Deg.) in Spontaneously Hypertensive Rats

Konta

Almeida

Amaral

et al. 2013

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…58 The consumption of P. edulis juice did not improve antioxidant enzyme status but did decrease the blood TBARS levels, indicating that the antioxidant capacity may be related to the addition of exogenous antioxidants present in the juice. 59 However, although Rudnicki et al 60 did not observe changes in liver MDA levels, the consumption of the hydroalcoholic extracts of both P. alata and P. edulis leaves had significant protective effects against carbonyl protein formation and advanced glycation end-products. In addition, those authors observed a linear relationship between total phenolic content and total antioxidant activity, indicating that these compounds might be the major contributors to animal's antioxidant activities.…”

Section: Resultsmentioning

confidence: 92%

Passiflora edulispeel intake and ulcerative colitis: Approaches for prevention and treatment

Cazarin

Silva

Colomeu

et al. 2014

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Inflammatory bowel disease is a chronic relapsing disease that affects millions of people worldwide; its pathogenesis is influenced by genetic, environmental, microbiological, and immunological factors. The aim of this study was to evaluate the effects of short- and long-term Passiflora edulis peel intake on the antioxidant status, microbiota, and short-chain fatty acids formation in rats with 2,4,6-trinitrobenzenesulphonic acid-induced colitis using two "in vivo" experiments: chronic (prevention) and acute (treatment). The colitis damage score was determined using macroscopic and microscopic analyses. In addition, the antioxidant activity in serum and other tissues (liver and colon) was evaluated. Bifidobacteria, lactobacilli, aerobic bacteria and enterobacteria, and the amount of short-chain fatty acids (acetic, butyric, and propionic acids) in cecum content were counted. Differences in the colon damage scores were observed; P. edulis peel intake improved serum antioxidant status. In the treatment protocol, decreased colon lipid peroxidation, a decreased number of aerobic bacteria and enterobacteria, and an improvement in acetic and butyric acid levels in the feces were observed. An improvement in the bifidobacteria and lactobacilli was observed in the prevention protocol. These results suggested that P. edulis peel can modulate microbiota and could be used as source of fiber and polyphenols in the prevention of oxidative stress through the improvement of serum and tissue antioxidant status.

show abstract

“…The PFJ used in this study was a commercially available PFJ produced from purple passion fruits at Doi Kham Food Products Co. Ltd., (Chiang Rai, Thailand). The concentration of PFJ was 50% (50 g/100 mL) according to a previous study by de Souza Mda et al (2012), which reported productive effects of PFJ supplementation at 1 g/kg on improving levels of plasma lipid and oxidative stress. One hundred mL of the juice provided 55 kcal, consisting of 12.5 g sugars, 1 g other carbohydrate, <0.5 g dietary fibers, and 10 g sodium.…”

Section: Methodsmentioning

confidence: 99%

Acute Effects of Passion Fruit Juice Supplementation on Cardiac Autonomic Function and Blood Glucose in Healthy Subjects

Prasertsri¹,

Booranasuksakul²,

Naravoratham³

et al. 2019

pnf

View full text Add to dashboard Cite

Ascorbic acid supplementation provides beneficial effects on enhancing cardiac autonomic function in patients with heart failure. Ascorbic acid also reduces blood sugar levels and enhances insulin activity, and encourages cardiac autonomic function. Passion fruit is rich in ascorbic acid and potential antioxidants. This study aimed to evaluate the acute effects of passion fruit juice (PFJ) supplementation primarily on cardiac autonomic function and secondary on blood glucose in healthy subjects. A randomized cross-over trial was conducted in 14 healthy subjects aged 21.29±0.73 years. Subjects were supplemented with either 50% PFJ, or glucose and fructose solution as a placebo (PLA) at 3.5 mL/kg body mass with a 1-week washout between treatments in a single-dose design. Short-term heart rate variability and blood glucose levels were evaluated prior to supplementation (T0) and following supplementation for 30, 60, 90, and 120 min (T30, T60, T90, and T120, respectively). Indexes of cardiac autonomic function at T30, including high frequency power (P=0.03) and total power (P=0.01), were significantly higher and the ratio of low frequency/high frequency power was significantly lower (P=0.01) in the PFJ group compared to the PLA group. Blood glucose levels significantly increased at T30 in both PLA (P=0.00) and PFJ (P=0.00) groups. However, there were no significant differences between groups. A single administration of PFJ enhanced cardiac autonomic function through augmentation of parasympathetic activity, although it did not attenuate postprandial hyperglycemia. PFJ may be potentially recognized as beverage able to prevent cardiovascular disease.

show abstract

Effects ofPassiflora edulis(Yellow Passion) on Serum Lipids and Oxidative Stress Status of Wistar Rats

Cited by 27 publications

References 36 publications

Evaluation of the Antihypertensive Properties of Yellow Passion Fruit Pulp (Passiflora edulis Sims f. flavicarpa Deg.) in Spontaneously Hypertensive Rats

Evaluation of the Antihypertensive Properties of Yellow Passion Fruit Pulp (Passiflora edulis Sims f. flavicarpa Deg.) in Spontaneously Hypertensive Rats

Passiflora edulispeel intake and ulcerative colitis: Approaches for prevention and treatment

Acute Effects of Passion Fruit Juice Supplementation on Cardiac Autonomic Function and Blood Glucose in Healthy Subjects

Contact Info

Product

Resources

About