Effect of Beconase nasal spray on olfactory function in post-nasal polypectomy patients: a prospective controlled trial

Abstract

Numerous studies have postulated the possible benefit of corticosteroids on olfaction in patients with nasal/sinus disease. Twenty-nine patients with bilateral nasal polyps were included in our study using strict selection criteria to reduce other aetiologies of olfactory dysfunction. The University of Pennsylvania Smell Identification Test (UPSIT) was performed pre-operatively on the right and left nostrils separately. Following intranasal polypectomy the patients received a six-week course of beclomethasone nasal spray (Beconase) to one nostril only, with the other acting as a control. The UPSIT scores were again obtained for each nostril separately. Wilcoxon Signed Rank test revealed no statistically significant difference in UPSIT scores between treated and untreated nostrils (p = 0.31; power 70 per cent; ES = 0.47). We conclude that topical beclomethasone does not improve olfaction following nasal polypectomy.

Chronic Rhinosinusitis and Olfactory Dysfunction

“…The study did not mention to what extent medical treatment was employed following surgery. That same year, El Nagger et al [54] attempted to quantitatively assess the effect of steroid nasal spray on olfaction after nasal polypectomy. Twenty-nine patients with bilateral nasal polyps received a 6-week course of beclomethasone nasal spray following intranasal polypectomy.…”

Riechstörungen

“…Darüber hinaus gibt es nur eine kontrollierte Studie,die die Wirksamkeit von topischen Steroiden auf das Riechvermö-gen von Patienten mit Nasenpolypen mit einem reproduzierbaren Verfahren, dem UPSIT (University of Pennsylvania Smell Identification Test [9]),untersucht hat [12]. Dabei konnten el Naggar et al keine zusätzliche Wirksamkeit von Beconasespray beobachten, wenn nach bilateralen Polypektomien für 6 Wochen unilateral in eine, zufällig ausgewählte Nasenseite gesprüht wurde [12].…”

“…Dabei konnten el Naggar et al keine zusätzliche Wirksamkeit von Beconasespray beobachten, wenn nach bilateralen Polypektomien für 6 Wochen unilateral in eine, zufällig ausgewählte Nasenseite gesprüht wurde [12].…”

Chronic rhinosinusitis and emerging treatment options

“…The steroid agents used were fluticasone propionate,43–56 beclomethasone dipropionate,46,51,57–59 betamethasone sodium phosphate,60 mometasone furoate,64 flunisolide,65,66 and budesonide 67–75. When compared to placebo, the steroid group could decrease symptom scores by 0.46 (95% confidence interval [CI] 0.27–0.65) and decrease polyp size score by 0.48 (95% CI 0.21–0.75).…”