Effect of behavioral inhibition system and childhood emotional neglect on serotonergic activity, negative affect, and rejection sensitivity in non-clinical adults

Abstract

IntroductionBehavioral inhibition system (BIS) has a strong genetic basis, and emotional neglect (EN) in childhood is one of many environmental experiences that can affect individuals. This study aimed to examine the effects and interaction between BIS and EN on central serotonergic activity and other negative affect and cognition.MethodsA total of 153 non-clinical volunteers (54 men and 99 women; average age, 27.72 years, standard deviation = 6.40) were included in the analyses. The Behavioral Inhibition System scale, Childhood Trauma Questionnaire, and negative affect and cognition (Beck Depression Inventory, State-Trait Anxiety Inventory, and Rejection Sensitivity Questionnaire) were measured. As a biomarker of central serotonergic activity, the loudness dependence of auditory evoked potentials was measured.ResultsHigh EN was associated with higher loudness dependence of auditory evoked potential (LDAEP) levels and low EN was associated with lower LDAEP levels in high BIS people only. People with high EN people showed significantly higher levels of depression and state anxiety than did those with low EN. Moreover, of people with low BIS, those who had more EN experience had higher levels of rejection sensitivity than did those with less EN experience, while people with high BIS did not show different patterns of rejection sensitivity regardless of the difference of EN.ConclusionsThis study revealed different effects on physiological (loudness dependence of auditory evoked potentials), intrapersonal (depression and state anxiety), and interpersonal aspects (rejection sensitivity) based on the interaction of BIS and EN. Our results suggest that the physiological and interpersonal aspects, but not the intrapersonal aspect, are significantly influenced by the interactive effect of BIS and EN.

The influence of childhood emotional neglect experience on brain dynamic functional connectivity in young adults

“…Their correlation analysis showed that positive mood was positively correlated with flexibility. Moreover, individuals with CEN, even adults, still have more negative affectivity (Jin et al, 2018 ; Schimmenti et al, 2015 ). For example, Schimmenti et al ( 2015 ) examined the relationships between CEN, current psychiatric symptoms, and negative affectivity in community adults.…”

Commonality of Emotional Trauma in Performing Arts: Implications for Training Programs

“…For the purposes of this paper, emotional neglect is the result of a caregiver's inability to provide healthy emotional stimulation due to organic issues with the caregiver, such as struggling with unresolved trauma creating low maternal/paternal warmth, substance use disorder, mental health issues, developmental disability, and/or mental health issues. Poverty can also create considerable environmental issues that result in unintentional emotional neglect (Jin et al, 2018). Psychological abuse is purposeful maltreatment that is executed with the intention to harm and/or punish a child.…”

Association Between Frontal Alpha Asymmetry With Cognitive Symptoms, Depression Severity, and Insomnia

“…A Neuroscan Syn-Amps amplifier (Compumedics USA, El Paso, TX, USA) with 64 Ag-AgCl electrodes on a Quik-Cap was used to record the EEG in an extended 10-20 placement scheme. The specific protocol has been described elsewhere [26,27].…”