Effect of Benzoyl Peroxide on Skin Surface Lipids

Fanta, D; Müller, Michele

doi:10.1159/000250743

Cited by 10 publications

(8 citation statements)

References 3 publications

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“…Our findings are at variance with those published previously by Fanta and Müller [3]. They reported that when 5% benzoyl peroxide gel was applied to the face of 10 subjects for 4 weeks, the average 'casual' sebum levels de creased by 52% and the 'replacement sum' sebum levels by 55%.…”

Section: Discussioncontrasting

confidence: 81%

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Failure of Benzoyl Peroxide to Decrease Sebaceous Gland Secretion in Acne

Goldstein¹,

Pochi²

1981

Dermatology

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10 male patients with inflammatory facial acne were treated for 6 weeks with a 10% benzoyl peroxide gel (PanOxyl®-10) applied to the forehead. There was no significant mean change in sebaceous gland secretion after 4, 5, and 6 weeks of treatment. These findings are at variance with a previously published study which showed that 5% benzoyl peroxide gel inhibited sebaceous gland secretion. Conflicting results from the two studies may be due to differences in patient populations or, more likely, in technical factors, such as the methods used for sebum production, collection, and analysis.

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Section: Discussioncontrasting

confidence: 81%

“…More recently, attention has been directed to the possibility that benzoyl per oxide can inhibit sebaceous gland secretion. Studies have been reported to indicate that it lowers surface sebum levels and sebaceous gland mitotic ac tivity in man [3,4] and sebaceous gland size and mitotic activity in ani mals [5].…”

Section: Introductionmentioning

confidence: 99%

Failure of Benzoyl Peroxide to Decrease Sebaceous Gland Secretion in Acne

Goldstein¹,

Pochi²

1981

Dermatology

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“…Analysis of treatment and control data of individual subjects showed a de crease of SER in 4 out of 14 patients (pa tients No. 5,6,8,12), whereas a concomit ant SER reduction was observed in both treatment and control areas of 6 patients ( fig. 1).…”

Section: Resultsmentioning

confidence: 83%

“…BPO was reported to produce a primary irritant dermatitis, and patients did not re port an improvement of seborrhea [1,2], In direct methods of assessing sebum pro duction were found to indicate a sebosuppressive effect of BPO [5,8], More estab lished methods for estimating SER also sug gested that BPO exerted a sebosuppressive effect [6] and clinical observations corrobo rated these observations [4], Other studies failed to show that BPO decreases sebaceous gland secretion in acne [10,13,16]. Recent- ly, 5% BPO was reported to increase SER by 22.5% in acne patients after 1 and 2 months of treatment [2].…”

Section: Discussionmentioning

confidence: 99%

“…These findings, together with the dry appearance of the skin during treatment [4], indicated a sebum-sup pressive mode of action of BPO. Fanta and Midler [6] described a significant reduction of casual levels and sebum excretion rates (SER) in 10 patients treated with 5% BPO gel after 4 weeks of treatment. But other studies did not corroborate the sebum-sup pressive effect of BPO [13,16].…”

Section: Introductionmentioning

confidence: 99%

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Sebum Suppression by Benzoylperoxide

et al. 1985

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Sebum excretion rate (SER) was determined by thin-layer chromatography and based on densitometric data in 9 male and 5 female patients suffering from acne during treatment with 10% benzoylperoxide (BPO). BPO was applied to the forehead (treatment area), whereas gel only was applied to the chest (control area) for 6 weeks. SER decreased in 10/14 subjects, no change was found in 1 subject and 3 patients exhibited an increase in SER. Suppression varied between 12 and 86%. Concomitant SER reduction in control and treatment areas was noted in 6 patients. When treatment and control areas of individual patients were considered for data evaluation, SER decrease was noted in only 4 out of 14 subjects. Similar results were obtained when free fatty acids, triglycerides and squalene data were analyzed. Combined, these data suggest that BPO may affect SER in some patients. The present experiments indicate the importance of adequate controls in such studies.

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Cyproteronacetat, Östradiol, Benzoylperoxid eine Gegenüberstellung der Wirkeffekte auf die Talgdrüse

Wirth

1980

Fette, Seifen, Anstrichm.

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Bei der sebosuppressiven Behandlung der Akne kann man zwischen einer hormonellen und einer nicht‐hormonellen Therapie unterscheiden. In der modernen Therapie spielen bei den nicht‐hormonellen Pharmaka Benzoylperoxid, bei den hormonellen Pharmaka vor allem Östradiol und Antiandrogene eine Rolle. D. Fanta et al. und unser eigener Arbeitskreis konnten durch lipidanalytische und autoradiographische Untersuchungen zur Zellkinetik der Talgdrüse die sebosuppressive Wirkung von Benzoylperoxid nachweisen. Klinische und autoradiographische Untersuchungen zahlreicher Autoren zeigten die positive Wirkung von Östradiol und Cyproteronacetat bei der sebosuppressiven Behandlung der Akne. Bei unseren Untersuchungen an den Ohren von syrischen Goldhamstern sollte überprüft werden, ob die Zellkinetik der Talgdrüse durch hormonelle und nicht‐hormonelle Pharmaka unterschiedlich beeinflußt wird. Hierzu wurde die Autoradiographie zur Bestimmung des Thymidin‐Labelling‐Index und der DNS‐Synthesezeit sowie die Colcemidmethode zur Bestimmung des Mitoseindex herangezogen.

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Effect of Benzoyl Peroxide on Skin Surface Lipids

Cited by 10 publications

References 3 publications

Failure of Benzoyl Peroxide to Decrease Sebaceous Gland Secretion in Acne

Failure of Benzoyl Peroxide to Decrease Sebaceous Gland Secretion in Acne

Sebum Suppression by Benzoylperoxide

Cyproteronacetat, Östradiol, Benzoylperoxid eine Gegenüberstellung der Wirkeffekte auf die Talgdrüse

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