Effect of Bergenia crassifolia L. extracts on weight gain and feeding behavior of rats with high-caloric diet-induced obesity

Shikov, Alexander N.; Pozharitskaya, Olga N.; Макарова, М.Н.; Kovaleva, M.A.; Laakso, Into; Dorman, H. J. Damien; Hiltunen, R.; Makarov, Valery G.; Galambosi, Bertalan

doi:10.1016/j.phymed.2012.09.019

Cited by 27 publications

(13 citation statements)

References 48 publications

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“…Several medicinal plants including Platycodon Grandiflorum, Berberine, and Green Tea have anti-obesity and lipid (TG, TC and LDL) lowering properties. They also improved obesity associated metabolic problems such as cardiovascular diseases through normalizing lipid profile (22).…”

Section: Discussionmentioning

confidence: 99%

Anti-Dyslipidemic Properties of Saffron: Reduction in the Associated Risks of Atherosclerosis and Insulin Resistance

Hoshyar

Hosseinian

Naghandar

et al. 2016

Iran Red Crescent Med J

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Section: Discussionmentioning

confidence: 99%

Anti-Dyslipidemic Properties of Saffron: Reduction in the Associated Risks of Atherosclerosis and Insulin Resistance

Hoshyar

Hosseinian

Naghandar

et al. 2016

Iran Red Crescent Med J

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“…Bergenia crassifolia (L.) Fritsch, belonging to the genus Bergenia ( Saxifragaceae ), is widely used in Poland, Ukraine, Russia, Mongalia, Siberia, and Xinjiang in China as a folk medicine or tea ( Shikov et al, 2010 , 2012 ). This plant is commonly known as badan, Siberian tea, Mongolian tea, leather bergenia, winter-blooming bergenia, heartleaf bergenia and elephant’s ears ( Vereschagin et al, 1959 ).…”

Section: Introductionmentioning

confidence: 99%

Anti-biofilm Activities from Bergenia crassifolia Leaves against Streptococcus mutans

Liu

Song

et al. 2017

Front. Microbiol.

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Streptococcus mutans has been reported as a primary cariogenic pathogen associated with dental caries. The bacteria can produce glucosyltransferases (Gtfs) to synthesize extracellular polysaccharides (EPSs) that are known as virulence factors for adherence and formation of biofilms. Therefore, an ideal inhibitor for dental caries is one that can inhibit planktonic bacteria growth and prevent biofilm formation. Bergenia crassifolia (L.), widely used as a folk medicine and tea beverage, has been reported to have a variety of bioactivities. The present study aimed to explore the effect of B. crassifolia (L.) leaf extracts on the biofilm of Streptococcus mutans. The B. crassifolia (L.) leaf extracts showed inhibitory effects by decreasing viability of bacteria within the biofilm, as evidenced by the XTT assay, live/dead staining assay and LDH activity assay, and could decrease the adherence property of S. mutans through inhibiting Gtfs to synthesize EPSs. In addition, the reduced quantity of EPSs and the inhibition of Gtfs were positively correlated with concentrations of test samples. Finally, the MTT assay showed that the extracts had no cytotoxicity against normal oral cells. In conclusion, the extracts and sub-extracts of B. crassifolia leaves were found to be antimicrobial and could reduce EPS synthesis by inhibiting activities of Gtfs to prevent bacterial adhesion and biofilm formation. Therefore, B. crassifolia leaves have potential to be developed as a drug to prevent and cure dental caries.

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“…They form stable complexes and decrease structural flexibility of the enzyme Souza et al, 2011), making it insoluble to the reaction medium, inactivating it (Bhutani et al, 2007;Shikov et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Stem bark extracts of Endopleura uchi (Huber) Cuatrec: Inhibition of pancreatic lipase and antioxidant activity

Gustavo¹,

Anderson²,

Luciana³

et al. 2017

J. Med. Plants Res.

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Pancreatic lipase is considered an important target for the control of hyperlipidemia. Several plants, especially those rich in phenolic metabolites, have been shown to have anti-hyperlipidemic activity and are considered a good alternative for obesity prevention. Extracts of the stem bark of Endopleura uchi (Huber) Cuatrec (Humiriaceae) were evaluated for the inhibitory activity on the pancreatic lipase enzyme, as well as their antioxidant potential were verified in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) test. In addition, the total phenolics (TPC) and flavonoids contents (TFC) were estimated. In general way, the acetonic and ethanolic extracts showed better results than aqueous extract. At the concentration of 1 mg/mL, both acetonic and ethanolic extracts inhibited the activity of pancreatic lipase by 49.33 and 36.88%, representing 135.26 and 102.75 of inhibited lipase activity per gram of extract (ILA/g). On the other hand, the aqueous extract inhibited lipase by 47.54% at the concentration of 2 mg/mL, which means 213.84 ILA/g. The highest antioxidant activity was observed for the acetonic extract with a 50% effective concentration (EC 50 ) of 7.9 µg/mL, followed by the ethanolic extract with EC 50 of 9.7 µg/mL and the aqueous extract with EC 50 of 12.4 µg/mL. TPC in gallic acid equivalent per gram of sample (GAE/g) were 0.52, 0.51 and 0.35 respectively for the ethanolic, acetonic and aqueous extracts. In turn, TFC in quercetin equivalent per gram of sample (QE/g) were 2.13, 1.89 and 1.35 for the acetonic, ethanolic and aqueous extracts, respectively. Positive and strong correlations (r Pearson > 9.0) between TPC and antioxidant activity were found for all 3 extracts. These results suggest that both pancreatic lipase inhibition and antioxidant activity were distinguished by organic solvents and water extraction. Furthermore, organic extracts (acetone and ethanol) showed to be richer in phenolic metabolites. These metabolites may be related to the biological activities that were found, indicating the stem bark extracts of E. uchi as possible candidates for the development of strategies in the prevention of obesity and hyperlipidemia.

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Effect of Bergenia crassifolia L. extracts on weight gain and feeding behavior of rats with high-caloric diet-induced obesity

Cited by 27 publications

References 48 publications

Anti-Dyslipidemic Properties of Saffron: Reduction in the Associated Risks of Atherosclerosis and Insulin Resistance

Anti-Dyslipidemic Properties of Saffron: Reduction in the Associated Risks of Atherosclerosis and Insulin Resistance

Anti-biofilm Activities from Bergenia crassifolia Leaves against Streptococcus mutans

Stem bark extracts of Endopleura uchi (Huber) Cuatrec: Inhibition of pancreatic lipase and antioxidant activity

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