Effect of bile salts on drug release from HPMC matrices

Tablets With Material Gradients Fabricated by Three-Dimensional Printing

“…For SLS, owing to ion-dipole interaction and hydrophobic bonding in the presence of water, it was able to cause an apparent increase in molecular weight and in viscosity of an aqueous solution of the HPMC, [17][18][19][20] and thus enhanced the gel strength to make the tablets less susceptible to erosion. For SA, the release-retardation effect was mainly attributed to the hydrophobic nature by which it could inhibit the dissolution of the drug and HPMC from the front edge of the tablets through restraining the wetting and penetration of the dissolution medium.…”

New clothes for covered stents

“…For SLS, owing to ion–dipole interaction and hydrophobic bonding in the presence of water, it was able to cause an apparent increase in molecular weight and in viscosity of an aqueous solution of the HPMC,17–20 and thus enhanced the gel strength to make the tablets less susceptible to erosion. For SA, the release‐retardation effect was mainly attributed to the hydrophobic nature by which it could inhibit the dissolution of the drug and HPMC from the front edge of the tablets through restraining the wetting and penetration of the dissolution medium.…”

“…It has been broadly reported that incorporation of additives such as nonionic hydrophobic polymers,8–11 acrylic resin polymers,12–14 insoluble waxy materials,15, 16, or anion surfactants17–20 has a significant influence on the properties of hydrophilic matrix tablets based on hydroxypropyl methylcellulose (HPMC), and hence the drug release profiles. In order to evaluate their potential to modify drug release profiles in 3DP tablets containing HPMC, ethyl cellulose (EC), Eugragit RS‐100, stearic acid (SA), and sodium lauryl sulfate (SLS) were employed as release‐retardation materials respectively in the preparation of hydrophilic matrix tablets.…”