Effect of Bile Salts on Antral Gastrin Release

Bedi, B.S.; Debas, Haile T.; Gillespie, G; Gillespie, Iain

doi:10.1016/s0016-5085(71)80145-2

Cited by 49 publications

(8 citation statements)

References 13 publications

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“…The increase was in this case probably not caused by reflux of substantial amounts of alkaline duodenal contents, since the juice from the gastric cannula in all experiments was of high acidity. It has been reported that bile salts are able to release gastrin (Bedi et al 1971). Such a mechanism could have been operating in the present experiments as some bile regurgitation into the main stomach frequently took place when cholecystokinin was infused.…”

Section: Acid Secretionmentioning

confidence: 63%

Effects of Secretin, Cholecystokinin and Caerulein on Gastric Secretion in Response to Sham Feeding in Dogs

Sjödin¹

1972

Acta Physiologica Scandinavica

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SJODIN, L. Effects of secretin, cholecystokinin and caerulein on gastric secretion inresponse to sham feeding in dogs. Acta physiol. scand. 1972. 85. 99-109. Secretin (0.75-3.0 U/kg/h) did not regularly inhibit the acid secretory response to 10 min of sham feeding to a significant degree in 3 dogs with intact antrum. Cholecystokinin (0.75-5.0 U/kg/h) and caerulein (0.06-0.30 p/kg/h) tended to increase acid output after sham feeding in these dogs. In antrectomized dogs the response to sham feeding was markedly enhanced by cholecystokinin (0.6-2.4 U/kg/h) and caerulein (0.06 pg/kg/h). Pepsin output after sham feeding was increased by secretin (3.0 U/kg/h) and tended to be reduced by cholecystokinin (3.0 U/kg/h) and caerulein (0.30 pglkglh). These findings indicate that gastric acid secretion in response to sham feeding is not inhibited by physiological amounts of secretin and in fact increased by cholecystokinin and caerulein. The pepsin output after sham feeding can be enhanced by secretin and possibly depressed by cholecystokinin. The physiological significance of these effects on pepsin secretion remains to be determined.

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Section: Acid Secretionmentioning

confidence: 63%

Effects of Secretin, Cholecystokinin and Caerulein on Gastric Secretion in Response to Sham Feeding in Dogs

Sjödin¹

1972

Acta Physiologica Scandinavica

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“…This inverse relationship between gastrin release and gastric acidity has been described in atrophic gastritis (Ganguli, Cullen & Irvine, 1971;Strickland, Bhathal, Kor-man & Hansky, 197 1). However, this is a complex problem, as it has been observed that bile salts stimulate the release of gastrin from the canine antrum (Bedi, Wasunna & Gillespie, 1969), yet on the other hand the involvement of the antrum by gastritis may reduce antral gastrin secretion . In patients with both duodenal and gastric ulcers a higher gastrin secretion is associated with a higher acid secretion.…”

Section: Discussionmentioning

confidence: 99%

Gastric Ulcers with and without Associated Duodenal Ulcer Have Different Pathophysiology

Lam

Lai

1978

Clinical Science

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1. Maximal acid output after pentagastrin stimulation, and fasting and postprandial serum gastrin concentrations were determined in 25 normal subjects, 30 patients with corpus gastric ulcers, 10 patients with prepyloric ulcers and 30 patients with both duodenal and gastric ulcers. 2. Corpus ulcers and prepyloric ulcers formed one distinct group. Maximal acid output was abnormally low in the corpus ulcer patients and no different from normal in prepyloric ulcer patients, whereas fasting serum gastrin and postprandial integrated gastrin response was abnormally high in the former and no different from the normal in the latter. Furthermore, as in the normal subjects, a significant negative correlation between maximal acid output expressed in mmol h(-1) kg(-1) body weight and postprandial integrated gastrin response was observed in the corpus and prepyloric ulcer patients taken as a group. 3. In complete contrast patients with both duodenal and gastric ulcers, in whom postprandial integrated gastrin response was statistically highest amongst the three types of gastric ulcers, had a significantly positive correlation between maximal acid output and the integrated gastrin response. 4. These findings suggest the operation of different pathophysiological mechanisms in gastric ulcers with and without associated duodenal ulcers.

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“…This has been demonstrated in animal experimenta-:800 t-tion (Cross and Wangensteen, 1951;Lambert, 1962;Levrat et al, 1962;Moffat and Berkas, 1965;Gillison 6oog et al, 1972;Henderson et al, 19731, postoperatively 2 in patients following gastrectomy (Helsingen, 1960; -400 3 Cox, 1961;Kleckner et al, 1972) and in patients with -;:: achlorhydria (Palmer, 1960;Orlando and Bozymski, 1973). There is other evidence to show that the effect .loo of bile on gastric and oesophageal rnucosa is deleterious (Grant et al, 1951;Davenport, 1968;Geall et al, 1970;Black et al, 1971;Bedi et al, 1971;Safaie-Shirazi and DenBesten, 1973).…”

Section: Bile Salt Concentration a Total Bile Salts (Fasting)mentioning

confidence: 96%

The pattern of bile salt reflux and acid secretion in sliding hiatal hernia

Crumplin

Stol

Murphy

et al. 1974

Journal of British Surgery

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The role played by gastric fluid refluxed from the stomach into the oesophagus of patients with symutomatic sliding hiatal hernia has been evaluated in terms of gastric bile salt concentration and acid secretion rates. Patients with a peptic stricture had a higher basal acid output than control subjects. Approximately half of both hiatal hernia groups studied had periods of increased total bile salt concentrations either while fasting or following a test meal, This would indicate abnormal pyloric function in these patients. The quantitative examination of total and individual bile salts in solution in gastric juice suggests that a combination of gastric acid pepsin and bile may be a major, factor in the pathogenesis of the clinical responses to gastrooesophageal reflux. Neither total nor individual bile salt concentrations found in gastric juice helped to differentiate between the specific types of response seen in symptomatic sliding hiatal hernia.

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Effect of Bile Salts on Antral Gastrin Release

Cited by 49 publications

References 13 publications

Effects of Secretin, Cholecystokinin and Caerulein on Gastric Secretion in Response to Sham Feeding in Dogs

Effects of Secretin, Cholecystokinin and Caerulein on Gastric Secretion in Response to Sham Feeding in Dogs

Gastric Ulcers with and without Associated Duodenal Ulcer Have Different Pathophysiology

The pattern of bile salt reflux and acid secretion in sliding hiatal hernia

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