Effects of Secretin, Cholecystokinin and Caerulein on Gastric Secretion in Response to Sham Feeding in Dogs

Abstract

SJODIN, L. Effects of secretin, cholecystokinin and caerulein on gastric secretion inresponse to sham feeding in dogs. Acta physiol. scand. 1972. 85. 99-109. Secretin (0.75-3.0 U/kg/h) did not regularly inhibit the acid secretory response to 10 min of sham feeding to a significant degree in 3 dogs with intact antrum. Cholecystokinin (0.75-5.0 U/kg/h) and caerulein (0.06-0.30 p/kg/h) tended to increase acid output after sham feeding in these dogs. In antrectomized dogs the response to sham feeding was markedly enhanced by cholecystokinin (0.6-2.4 U/kg/h) and caerulein (0.06 pg/kg/h). Pepsin output after sham feeding was increased by secretin (3.0 U/kg/h) and tended to be reduced by cholecystokinin (3.0 U/kg/h) and caerulein (0.30 pglkglh). These findings indicate that gastric acid secretion in response to sham feeding is not inhibited by physiological amounts of secretin and in fact increased by cholecystokinin and caerulein. The pepsin output after sham feeding can be enhanced by secretin and possibly depressed by cholecystokinin. The physiological significance of these effects on pepsin secretion remains to be determined.

Actions and possible hormonal functions of circulating neurotensin

“…Ingestion of fat also inhibits the motility in the digestive tract. Moreover, as already indicated, in dogs low doses of CCK potentiates the acid secretion caused by vagal stimulation (Sjodin, 1972). Fat, like neurotensin, is also known to inhibit the rnyoelectric motor complexes in the small intestine (Al-Saf€ar & Rosell, 1981;Nebel & Castell, 1972;Thor et al, 1980).…”

“…Similarly, if the pouch is vagally denervated (Heidenhain pouch) neurotensin does not inhibit the gastric acid secretion (Anderson et a/., 1980). Chole-cystokinin in low doses inhibits the gastrin-induced acid secretion from vagally denervated pouches, but potentiates the acid secretion caused by vagal stimulation (Sjodin, 1972). Secretin effectively inhibits the gastric acid sEcretion in denervated, but less so in innervated, fundic pouches (Sjodin & Miura, 1974).…”

“…Secretin effectively inhibits the gastric acid sEcretion in denervated, but less so in innervated, fundic pouches (Sjodin & Miura, 1974). Chole-cystokinin in low doses inhibits the gastrin-induced acid secretion from vagally denervated pouches, but potentiates the acid secretion caused by vagal stimulation (Sjodin, 1972). 'Gastric inhibitory polypeptide', GIP, is also a potent inhibitor of acid secretion from vagally denervated mucosa, but produces only a moderate reduction of vagally induced secretion from the innervated stomach (Pedersen & Brown, 1972).…”

Effect of Glucagon on Food-Induced Gastrointestinal Secretions

“…8], It is of interest that secretin, which resembles glucagon in its amino acid sequence and in some aspects of its physiological activity, fails to inhibit food-stimulated gastric secretion from the Pavlov pouch [12]. However, secretin was tested in a relatively small dose and it is not excluded that if this hormone were used in a dose equal to that used for glucagon in the present study, inhibition might be achieved.…”

An Approach to the Development of Drugs for Appetite Disorders

“…Of these agents, the best studied is cholecystokinin (CCK). The ability of CCK to decrease food intake was first demon strated in the early seventies by Sjodin [17] in dogs and Gibbs et al [18] Much controversy has existed concerning whether CCK truly produces satiety or whether the decrease in food intake it produces is an aversive phenomenon. Bil lington et al [21], using the differential satiety method, clearly showed that CCK was not aversive in rats.…”