Effect of Glucagon on Food-Induced Gastrointestinal Secretions

Abstract

The action of glucagon on gastrointestinal secretion has been studied in two groups of 3 dogs each. The group-A dogs were prepared with gastric fistulas, Pavlov pouches and pancreatic fistulas, while the dogs in group B possessed only gastric fistulas and biliary fistulas. Glucagon infused intravenously in a dose of 25 μg/kg-h, during a steady state of half maximal secretory response to food caused a marked inhibition of acid secretion from Pavlov pouches and bicarbonate and protein secretion from pancreatic fistula. Biliary secretion was not affected by glucagon.

Effect of acetylcholine, gastrin, and glucagon alone and in combination with secretin and cholecystokinin on the secretion of the isolated perfused rat pancreas

“…On the one hand, an inhibition of the exogenously or endogenously stimulated volume and enzyme secretion has been observed in animals [16,23,34] and in man [4,6,14]. On the other hand, an increase in these parameters was also noted [21,23,26].…”

“…The conflicting observations concerning the effect of acetylcholine [9,13,22,27,31], gastrin [3,5,11,12,24,28,30,32], and glucagon [4,6,14,16,21,23,26,34] on the pancreas may be caused by the fact that these conditions were not or only partly fulfilled. Therefore, this study was directed to determine the action of these stimuli given alone or in combination with secretin (S) and cholecystokinin (CCK) in the isolated perfused pancreas and by use of dose-response curves.…”

Glucagon Ameliorates Pancreatic Subcellular Redistribution of Lysosomal Enzyme in Rats with Acute Pancreatitis of Closed Duodenal Loop

“…Glucagon inhibits pancreatic enzyme secretion [6, 7, 8]and also prevents digestive enzyme synthesis in the pancreatic acinar cells [9]. These properties could be of great significance in reducing the amount of enzyme released by pancreatic cellular damage, with an associated decrease in autodigestion.…”

“…Glucagon has been reported to inhibit pancreatic secretion as well as protein and digestive enzyme synthesis by the pancreas [6, 7, 8, 9]. As a result of these observations, it was suggested that glucagon may be of therapeutic value in the treatment of acute pancreatitis.…”

The Effect of <i>L</i>-Amino Acids Given Intravenously on Gastric Secretion Stimulated by Pentagastrin in Dogs

“…The mechanism of this fall of pentagastrin-stimulated secretion is difficult to explain. Since the intravenously administered amino acids release pancreatic glucagon (18), which in turn is known to be capable of inhibiting gastric secretion (3,11,15), stimulated by pentagastrin (15), it is possible that en dogenously released glucagon might at least contribute to the observed inhibi tion of gastric secretion. It cannot be also excluded, that this fall could be attributed to the passage of gastric acid from the main stomach to the duodenum and triggering neurohormonal mechanisms inhibiting acid secretion from the Heidenhain pouch.…”