Effect of bioactive glass paste on efficacy and post-operative sensitivity associated with at-home bleaching using 20% carbamide peroxide: a randomized controlled clinical trial

Abstract

Background The aim of this study was to evaluate the effect of bioactive glass (BAG) 45S5 paste on colour change and tooth sensitivity (TS) when used in combination with 20% carbamide peroxide (CP) during at-home vital tooth bleaching. Methods Twenty-four patients were selected and assigned into two experimental groups (n = 12) in a double-blind study design. Each patient received 20% CP followed by the application of either BAG paste or non-active placebo paste. The shade evaluation was performed using a digital spectrophotometer based on the CIE L*a*b* colour space system at different time points and the overall colour changes ΔE were calculated. TS was evaluated using visual analogue scale (VAS). The values of ΔE and TS were statistically analysed using paired t-test. The level of statistical significance was established at p = 0.05. Results The overall colour changes (ΔE) between baseline and each time point showed no significant differences between BAG and placebo groups (p > 0.05). The use of BAG paste significantly decreased TS reported by the participants. Conclusions The association of BAG paste with at-home bleaching treatment presents a promising method as it decreased TS and did not deteriorate bleaching efficacy. Trial registration This study was approved and registered in the Australian New Zealand Clinical Trials Registry (ANZCTR) under Registration number: ACTRN12621001334897.

The Use of Toothpastes Containing Different Formulations of Fluoride and Bioglass on Bleached Enamel

“…Following this, atomic force microscopy (AFM), which is a type of SPM with a high-resolution three-dimensional (3D) imaging technique, was used for the characterisation of surface roughness [ 19 , 21 , 22 , 23 ]. In addition to the 2D images, all samples were also scanned using the AFM’s silicon tip (OTESPA-R3, Bruker, Santa Barbara, CA 93117, USA) with the tapping mode to provide 3D images from the same area for the optimal topographic visualisation.…”

“…In addition to the 2D images, all samples were also scanned using the AFM’s silicon tip (OTESPA-R3, Bruker, Santa Barbara, CA 93117, USA) with the tapping mode to provide 3D images from the same area for the optimal topographic visualisation. The tapping mode of the AFM has the advantage of avoiding any surface dragging effects of the tip on the surface [ 19 ].…”

“…Recently, bioactive glasses have been incorporated in toothpastes, dental varnish, prophy paste, cements, glass ionomers, acrylic and composite resins [ 14 , 15 , 16 , 17 , 18 , 19 ]. Interestingly, the bioactivity of these glasses is dependent on the compositional ratio of certain glass-forming system contents.…”

“…Bioactive glasses have been reported to be effective in remineralising early enamel carious lesions in comparison to other topical agents such as casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) [ 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. Bakry et al [ 18 ] demonstrated that the calcium sodium phosphosilicate (45S5 bioglass, NovaMin; of nominal weight composition: 45% SiO 2 , 24.5% Na 2 O, 24.5% CaO, 6% P 2 O 5 ) bioglass application was able to remineralise artificially-induced erosive enamel lesions which were stored in artificial saliva (pH: 6.5) for a period of two weeks.…”

“…It was reported that hypersensitivity reduced without any deteriorating effect. However, the study population was 24 for each group and the time period was seven days only [ 19 ], which is relatively short to assess the management of hypersensitivity.…”