Effect of bisphenol A exposure during early development on glucose metabolism and adipokine expression in adolescent female rats

Zhang, Ling; Zhang, Hong Yuan; Cui, Cui; Zhai, Liang; Jia, Li Hong

doi:10.1007/s13273-013-0047-7

Cited by 9 publications

(8 citation statements)

References 28 publications

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“…Of these, there were nine studies on mice, of which there were one, four and four studies, respectively, in Tier 1 (van Esterik et al, 2014 [RefID 7393]), Tier 2 (Malaisé et al, 2017 [RefID 4815]; Junge et al, 2018 [RefID 12262]; Susiarjo et al, 2015 [RefID 7022] and Wang et al, 2014b [RefID 7759]) and Tier 3 (Rubin et al., 2017 [RefID 6319]; Ziv‐Gal et al, 2015 [RefID 9143]; Dobrzyńska et al, 2015 [RefID 1644] and Patel et al, 2013 [RefID 5697]). There were 12 studies on rats, of which eight, four and zero studies in Tier 1 (Hass et al, 2016 [RefID 2610]; Jiang et al, 2014 [RefID 3190]; Song et al, 2014b [RefID 6829]; Desai et al ( 2018a ) [RefID 11817]; Dunder et al, 2018 [RefID 11866]; Xia et al, 2014 [RefID 8103]; Quan et al, 2017 [RefID 6025] and Uchtmann et al, 2020 [RefID 13784]), Tier 2 (Ma et al., 2013 [RefID 4748]; Mao et al, 2017 [RefID 4865]; Zhang et al, 2013 [RefID 8798] and Anteur et al, 2016 [RefID 13773]) and Tier 3, respectively. The doses that were found to increase the body weight were in the range 0.45–10,000 μg/kg bw per day.…”

Section: Assessmentmentioning

confidence: 99%

“…In male offspring, the glucose level was increased at 3 weeks, but not at 9 weeks, whereas in female offspring, no effects were observed at 3 weeks or 9 weeks. In the Tier 2 study Zhang et al ( 2013 ) [RefID 8798], only female rats were exposed on GD6–PND21 to 33 or 310 μg/dam during gestation, 80 or 758 μg/kg bw per day at the end of gestation. In F1 females, the glucose level was increased with 80 μg, but not with 758 μg at 7 weeks of age.…”

Section: Assessmentmentioning

confidence: 99%

“…F1 females were not studied. In Zhang et al ( 2013 ) [RefID 8798], F0 dams were exposed to 33 or 310 μg/dam during gestation, 80 or 758 μg/kg bw per day at the end of gestation, on GD6–PND21. In female offspring, the insulin level was increased with both doses.…”

Section: Assessmentmentioning

confidence: 99%

“…For the endpoint adiponectin , in this exposure period, six studies, five in rats (Dunder et al, 2018 [RefID 11866]; Lejonklou et al, 2017 [RefID 3975]; Zhang et al, 2013 [RefID 8798]; Song et al, 2014b [RefID 6829]; Leung et al, 2017 [RefID 3990]) and one in mice (van Esterik et al, 2014 [RefID 7393]), were identified.…”

Section: Assessmentmentioning

confidence: 99%

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Re‐evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs

Lambré¹,

Baviera²,

Bolognesi³

et al. 2023

EFS2

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In 2015, EFSA established a temporary tolerable daily intake (t‐TDI) for BPA of 4 μg/kg body weight (bw) per day. In 2016, the European Commission mandated EFSA to re‐evaluate the risks to public health from the presence of BPA in foodstuffs and to establish a tolerable daily intake (TDI). For this re‐evaluation, a pre‐established protocol was used that had undergone public consultation. The CEP Panel concluded that it is Unlikely to Very Unlikely that BPA presents a genotoxic hazard through a direct mechanism. Taking into consideration the evidence from animal data and support from human observational studies, the immune system was identified as most sensitive to BPA exposure. An effect on Th17 cells in mice was identified as the critical effect; these cells are pivotal in cellular immune mechanisms and involved in the development of inflammatory conditions, including autoimmunity and lung inflammation. A reference point (RP) of 8.2 ng/kg bw per day, expressed as human equivalent dose, was identified for the critical effect. Uncertainty analysis assessed a probability of 57–73% that the lowest estimated Benchmark Dose (BMD) for other health effects was below the RP based on Th17 cells. In view of this, the CEP Panel judged that an additional uncertainty factor (UF) of 2 was needed for establishing the TDI. Applying an overall UF of 50 to the RP, a TDI of 0.2 ng BPA/kg bw per day was established. Comparison of this TDI with the dietary exposure estimates from the 2015 EFSA opinion showed that both the mean and the 95th percentile dietary exposures in all age groups exceeded the TDI by two to three orders of magnitude. Even considering the uncertainty in the exposure assessment, the exceedance being so large, the CEP Panel concluded that there is a health concern from dietary BPA exposure.

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Section: Assessmentmentioning

confidence: 99%

Section: Assessmentmentioning

confidence: 99%

Section: Assessmentmentioning

confidence: 99%

Section: Assessmentmentioning

confidence: 99%

See 2 more Smart Citations

Re‐evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs

Lambré¹,

Baviera²,

Bolognesi³

et al. 2023

EFS2

View full text Add to dashboard Cite

show abstract

“…Insulin resistance and common property such as hypertension, hyperlipidemia, and abdominal obesity are common phenomenon in T2DM and obesity [ 8 ]. The prevalence rate of people who have both T2DM and obesity has rapidly increased all over the world every year, and the rates of increase show no signs of slowing [ 1 , 2 , 9 ]. Even though T2DM and obesity are a risk factor for cardiovascular disease, most of the treatment of metabolic syndrome only focuses on the reduction of blood glucose levels or the regulation of body weight.…”

Section: Introductionmentioning

confidence: 99%

Antihyperglycemic and Antiobesity Effects of JAL2 on db/db Mice

Lee

Kim

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Lonicera japonica Thunb. (LJT) and Rehmannia glutinosa Libosch. (RGL) have been used traditionally as a herbal medicine in Korean medicine. Using LC/Q-TOF was performed to profile the two herbal medicines and the mixture of LJR and RGL (JAL2, ratio 1 : 1). We performed oral glucose tolerance test (OGTT) and plasma GLP-1 and insulin secretion by multiplex assays to investigate antidiabetic effects of LJT, RGL, and JAL2 in db/db mice, the mice model of type 2 diabetes mellitus (T2DM). Also, the antiobesity-related factors such as plasma peptide YY (PYY), triglyceride, total cholesterol, HDL, LDL, and weight of liver, epididymal, and retroperitoneal fat tissue were investigated. Through the multiplex assay, it was found that JAL2 treatment more efficiently attenuated high levels of blood glucose by stimulating GLP-1 secretion and reduced LDL concentration and weight of liver and retroperitoneal fat tissue compared to LJT or RGL treated separately. These results suggest that the JAL2 has antidiabetes and antiobesity effects in T2DM mice model.

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Metabolic changes in marine medaka fish (Oryzias javanicus) in response to acute 4-nonlyphenol toxicity

Yum

Woo

2015

BioChip J

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Effect of bisphenol A exposure during early development on glucose metabolism and adipokine expression in adolescent female rats

Cited by 9 publications

References 28 publications

Re‐evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs

Re‐evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs

Antihyperglycemic and Antiobesity Effects of JAL2 on db/db Mice

Metabolic changes in marine medaka fish (Oryzias javanicus) in response to acute 4-nonlyphenol toxicity

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