Effect of Bisphenol A on the Testis of Offspring of White Albino Rats during Pregnancy and Lactation: (Light and Electron Microscopic Study)

Elhady, Al Sayed A. Abd; Autifi, Mohamed A.; Gizawy, Moustafa E. El; Yousef, Moaaz M.

doi:10.21608/ejhm.2021.178609

Cited by 2 publications

(2 citation statements)

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“…The histological analysis showed testicular toxicity as changes in spermatogenic cells, spermatids, Sertoli cells, and Leydig cells. However, higher doses of maternal dose exposure markedly increased all testicular parameters, displaying hypo spermatogenesis and leading to infertility [189].…”

Section: Industrialization Pregnancymentioning

confidence: 98%

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Developmental Programming in Animal Models: Critical Evidence of Current Environmental Negative Changes

et al. 2022

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The Developmental Origins of Health and Disease (DOHaD) approach answers questions surrounding the early events suffered by the mother during reproductive stages that can either partially or permanently influence the developmental programming of children, predisposing them to be either healthy or exhibit negative health outcomes in adulthood. Globally, vulnerable populations tend to present high obesity rates, including among school-age children and women of reproductive age. In addition, adults suffer from high rates of diabetes, hypertension, cardiovascular, and other metabolic diseases. The increase in metabolic outcomes has been associated with the combination of maternal womb conditions and adult lifestylerelated factors such as malnutrition and obesity, smoking habits, and alcoholism. However, to date, "new environmental changes" have recently been considered negative factors of development, such as maternal sedentary lifestyle, lack of maternal attachment during lactation, overcrowding, smog, overurbanization, industrialization, noise pollution, and psychosocial stress experienced during the current SARS-CoV-2 pandemic. Therefore, it is important to recognize how all these factors impact offspring development during pregnancy and lactation, a period in which the subject cannot protect itself from these mechanisms. This review aims to introduce the importance of studying DOHaD, discuss classical programming studies, and address the importance of studying new emerging programming mechanisms, known as actual lifestyle factors, during pregnancy and lactation.

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Section: Industrialization Pregnancymentioning

confidence: 98%

“…In addition, Yousef MM. [189] studied male albino rat offspring from mothers exposed to a low dose of bisphenol during gestation and lactation. The histological analysis showed testicular toxicity as changes in spermatogenic cells, spermatids, Sertoli cells, and Leydig cells.…”

Section: Industrialization Pregnancymentioning

confidence: 99%