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Introduction: The synthetic industrial and biomedical chemicals suspected to threat the health of the living organisms by disrupting their endocrine systems, referred to as endocrine disrupting chemicals (EDCs). Objective: To study the effects of Bisphenol A (BPA) on the natal and postnatal testis by the light and electron microscope to make sure if it is harmful or not on the development of male reproductive organs in albino rats. Matrial and Methods: Chemical used: Bisphenol A. The daily single oral dose was (0.3 mg/kg BW./day). Experimental animals: Adult female rats in proestrus cycle were caged overnight with adult males of proven fertility (1 male / 2 females / cage) and produced neonatal male rats.The offspring rats were divided into five main groups: Group I (Control offspring group), Group II (Experimental low dose treated offspring group with Bisphenol A (0.3 mg/kg BW./day) for two weeks, Group III (Experimental high dose treated offspring group; 12 mg/kg b.w/day), Group IV (First recovery group ), Group V (Second recovery group), Results: Chronic Bisphenol A administration produced testicular toxicity leading to marked serious histological changes of the testis including the spermatogenic cells, spermatids, Sertoli cells and Leydig cells. These testicular changes increased with the high dose intake of BPA indicating its cumulative toxic effects that caused hypospermatogenesis, leading to infertility. Conclusion: Bisphenol A administration causes testicular toxicity. So, these serious complications on testicular structure should be considered when buying any canned foods or drinks, because it is used nowadays on a large scale allover the world.

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Background: Rosuvastatin can decrease the low-density lipoprotein cholesterol to optimal goals. Adverse effects of rosuvastatin involve the kidneys. Multiple studies explained that these side effects are due to reducing coenzyme Q ten (Q10) levels. Objective: to throw light upon the histological changes in the renal cortex of albino rats treated with rosuvastatin and explore the impact of CoQ10 co-treatment. Methods: The study was done at the Pharmacology Department lab., Faculty of Medicine, Al-Azhar University between August and October 2019. Forty adult albino rats were used in the study as follows: Group I: formed of 8 rats, given 1 ml distilled water/day for one month orally; Group II: formed of 8 rats, given 1.8 milligrams/Kilogram/day of CoQ10 for one month orally; Group III: formed of 8 rats, given 0.72 milligrams/Kilogram/day of rosuvastatin for one month orally; Group IV: formed of 8 rats, given 0.72 milligrams/Kilogram/day of rosuvastatin and 1.8 milligrams/Kilogram/day of CoQ10 for one month orally; Group V: formed of 8 rats, received the same dose of rosuvastatin as in group III then the rats were sacrificed two weeks later. Results: In group III, there were severe histo-pathological changes in the renal corpuscles and tubules. Also, the biochemical results (serum urea and creatinine) were deteriorated. In groups V and IV, the biochemical results were improved significantly. The histological integrity of the renal cortex appeared to return to the normal features found in the control group I. Conclusion: This study revealed that CoQ10 might have a protective role against rosuvastatin nephrotoxicity.