Effect of bisphenol A on the myocardium of adult male albino rats and the possible role of lycopene

El-Haleem, Manal R. Abd; Abass, Marwa

doi:10.1097/01.ehx.0000414921.94640.de

Cited by 6 publications

(9 citation statements)

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“…BPA is an environmental pollutant that has been shown to produce varieties of health problems depending on the dosage and the duration of exposure. In the current study, exposure to BPA led to histopathological changes in the adult rat myocardium which was consistent with previous animal studies that described similar changes in the structure of myocardium after BPA exposure either with high doses of BPA[15] or for long lifetime exposure. [34] In the current study, the increased myocardial surface area was reported after 3 weeks of BPA treatment; however, Jiang et al .…”

Section: Discussionsupporting

confidence: 92%

“…[1011] However, most of these reports studied the biochemical and the functional disturbances in the cardiovascular system after prolonged exposure to high doses of BPA. [121314] In experimental animals, exposure to a high dose of BPA (50 mg BPA orally for 8 weeks) resulted in morphological and structural changes in the rat myocardium in the form of vacuolated myocytes, focal loss of myofibrils, and distorted mitochondria and tubular system,[15] however, the effect of exposure to low doses of BPA on the rat myocardium still elusive.…”

Section: Introductionmentioning

confidence: 99%

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Potential toxic effect of bisphenol A on the cardiac muscle of adult rat and the possible protective effect of Omega-3: A histological and immunohistochemical study

Bahey

Elaziz

Gadalla

2019

J Microsc Ultrastruct

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Bisphenol A (BPA) is intensely used in the production of polycarbonate plastics and epoxy resins. Recently, BPA has been receiving increased attention due to its link to various health problems that develop after direct or indirect human exposure. Previous studies have shown the harmful effect of high doses of BPA; however, the effect of small doses of BPA on disease development is controversial. The aim of this study was to investigate the effect of a low dose of BPA on the rat myocardium and to explore the outcome of coadministration of Omega-3 fatty acid (FA). Thirty adult male rats were divided equally into control group, BPA-treated group (1.2 mg/kg/day, intraperitoneally for 3 weeks), and BPA and Omega-3-treated group (received BPA as before plus Omega-3 at a daily dose of 300 mg/kg/day orally) for 3 weeks. Exposure to BPA resulted in structural anomalies in the rat myocardium in the form of disarrangement of myofibers, hypertrophy of myocytes, myocardial fibrosis, and dilatation of intramyocardial arterioles. On the other hand, mast cell density and media-to-lumen area ratio were not significantly altered. Interestingly, concomitant administration of Omega-3 FAs with BPA significantly reduced BPA-induced changes and provided a protective effect to the myocardium. In conclusion, exposure to a low dose of BPA could potentially lead to pathological alterations in the myocardium, which could be prevented by administration of Omega-3 FA.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Potential toxic effect of bisphenol A on the cardiac muscle of adult rat and the possible protective effect of Omega-3: A histological and immunohistochemical study

Bahey

Elaziz

Gadalla

2019

J Microsc Ultrastruct

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“…Several studies propose that BPA exposure may cause potential oxidative stress and inflammation in different tissues including the heart, liver, and kidneys . BPA decreases the activity of detoxifying enzymes including superoxide dismutase, glutathione (GSH) peroxidase, and catalase, which results in increased generation of reactive oxygen species (ROS) .…”

Section: Introductionmentioning

confidence: 99%

The protective activity of nanomicelle curcumin in bisphenol A‐induced cardiotoxicity following subacute exposure in rats

Valokola

Karimi

Razavi

et al. 2018

Environmental Toxicology

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Bisphenol A (BPA), an estrogenic compound, is used in manufacture of polycarbonate plastics and epoxy resins. Curcumin, the active ingredient of turmeric, is a potent protective compound against cardiac diseases. In this study the protective effect of nanomicelle curcumin on BPAinduced subchronic cardiotoxicity in rats was evaluated. Rats were divided into 6 groups including control, nanomicelle curcumin (50 mg/kg, gavage), BPA (50 mg/kg, gavage), nanomicelle curcumin (10, 25, and 50 mg/kg) plus BPA. The treatments were continued for 4 weeks. Results revealed that BPA significantly induced histophatological injuries including focal lymphatic inflammation, nuclear degenerative changes and cytoplasmic vacuolation, increased body weight, systolic and diastolic blood pressures, malondialdehyde and Creatine phosphokinase-MB level and decreased glutathione content in comparison with control group. In addition, in electrocardiographic graph, RR, QT, and PQ intervals were increased by BPA. Western blot analysis showed that BPA up-regulated phosphorylated p38 (p38-mitogen-activated protein kinase) and JNK (c-jun NH 2 terminal kinases), while down-regulated phosphorylated AKT (Protein Kinase B) and ERK1/2 (extracellular signal-regulated protein kinases 1 and 2). However, nanomicelle curcumin (50 mg/kg) significantly improved these toxic effects of BPA in rat heart tissue.The results provide evidence that nanomicelle curcumin showed preventive effects on subchronic exposure to BPA induced toxicity in the heart tissue in rats.

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“…There is growing evidence indicating a relationship between BPA exposure and an increased risk of hypertension, arrhythmia, heart attack, vascular diseases, and atherosclerosis in experimental animals and human populations (Bae, Kim, Lim, Park, & Hong, 2012; Patel, Raad, Sebag, & Chalifour, 2013; Yan et al, 2011). The underlying mechanisms may involve the induction of oxidative stress parameters such as malondialdehyde (MDA), reduced glutathione, systemic inflammation, deficiency of nitric oxide (NO) levels, and the inhibition of acetylcholinesterase (AchE) (Aboul Ezz, Khadrawy, & Mourad, 2015; El‐Haleem & Abass, 2012; Melzer, Rice, Lewis, Henley, & Galloway, 2010). Besides, BPA accelerated atherosclerosis by inducing the adhesion molecules expression, inflammatory reactions, and endoplasmic reticulum (ER) stress which are involved in the increasing macrophage proportions and influencing the function of endothelial cells, and smooth muscle cells (SMCs) in the arterial wall (Fang et al, 2014, 2015).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of green tea extract and epigallocatechin gallate effects on bisphenol A‐induced vascular toxicity in isolated rat aorta and cytotoxicity in human umbilical vein endothelial cells

Mohsenzadeh

Razavi

Imenshahidi

et al. 2020

Phytotherapy Research

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This study was designed to assess bisphenol A (BPA)‐induced vascular toxicity, the effectiveness of green tea extract and epigallocatechin gallate (EGCG) against BPA toxicity, and possible underlying mechanisms. In isolated rat aorta, contractile and relaxant responses as well as malondialdehyde levels were evaluated. Cell viability and effects on the protein levels of apoptotic (bax, bcl2, and caspase‐3), autophagic (LC3), and cell adhesion molecules were calculated using the MTT method and western blotting in human umbilical vein endothelial cells (HUVECs). BPA increased aorta MDA levels (p < .0001) and decreased vascular responses to KCl [20 and 40 mM (p < .0001), 80 mM (p < .001)], phenylephrine [10−8, 10−6, and 10−5 M (p < .001), 10−7 and 10−4 M (p < .0001)], and acetylcholine [10−6 M (p < .01), 10−5 and 10−4 M (p < .0001)]. In HUVECs, BPA enhanced the levels of LC3A/B, bax/bcl2 ratio, cleaved caspase‐3, and vascular cell adhesion molecule‐1. Green tea extract, EGCG, and vitamin E co‐treatment with BPA diminished the toxic effects of BPA. These findings provide evidence that green tea extract and EGCG possess beneficial effects in preventing BPA‐induced vascular toxicity through increasing the antioxidant activities and the regulation of signaling pathways.

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Effect of bisphenol A on the myocardium of adult male albino rats and the possible role of lycopene

Cited by 6 publications

References 68 publications

Potential toxic effect of bisphenol A on the cardiac muscle of adult rat and the possible protective effect of Omega-3: A histological and immunohistochemical study

Potential toxic effect of bisphenol A on the cardiac muscle of adult rat and the possible protective effect of Omega-3: A histological and immunohistochemical study

The protective activity of nanomicelle curcumin in bisphenol A‐induced cardiotoxicity following subacute exposure in rats

Evaluation of green tea extract and epigallocatechin gallate effects on bisphenol A‐induced vascular toxicity in isolated rat aorta and cytotoxicity in human umbilical vein endothelial cells

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