The protective activity of nanomicelle curcumin in bisphenol A‐induced cardiotoxicity following subacute exposure in rats

Abstract

Bisphenol A (BPA), an estrogenic compound, is used in manufacture of polycarbonate plastics and epoxy resins. Curcumin, the active ingredient of turmeric, is a potent protective compound against cardiac diseases. In this study the protective effect of nanomicelle curcumin on BPAinduced subchronic cardiotoxicity in rats was evaluated. Rats were divided into 6 groups including control, nanomicelle curcumin (50 mg/kg, gavage), BPA (50 mg/kg, gavage), nanomicelle curcumin (10, 25, and 50 mg/kg) plus BPA. The treatments were continued for 4 weeks. Results revealed that BPA significantly induced histophatological injuries including focal lymphatic inflammation, nuclear degenerative changes and cytoplasmic vacuolation, increased body weight, systolic and diastolic blood pressures, malondialdehyde and Creatine phosphokinase-MB level and decreased glutathione content in comparison with control group. In addition, in electrocardiographic graph, RR, QT, and PQ intervals were increased by BPA. Western blot analysis showed that BPA up-regulated phosphorylated p38 (p38-mitogen-activated protein kinase) and JNK (c-jun NH 2 terminal kinases), while down-regulated phosphorylated AKT (Protein Kinase B) and ERK1/2 (extracellular signal-regulated protein kinases 1 and 2). However, nanomicelle curcumin (50 mg/kg) significantly improved these toxic effects of BPA in rat heart tissue.The results provide evidence that nanomicelle curcumin showed preventive effects on subchronic exposure to BPA induced toxicity in the heart tissue in rats.

Protective Effect of Turmeric against Bisphenol-A Induced Genotoxicity in Rats

“…The results revealed that nanomicelle in curcumin could ameliorate BPA-induced toxic effects. Reduction in MDA level was observed in 50 mg/kg nanomicelle curcumin group compared to BPA groups (15). Urinary 8-OHdG is a sensitive marker for in vivo oxidative DNA damage and oxidative stress.…”

Bisphenol S and bisphenol F are less disruptive to cardiac electrophysiology and potentially safer for use in medical products, as compared to bisphenol A

“…Indeed, recent studies have shown that BPA can alter cardiac electrophysiology, likely through a calcium-dependent mechanism. Sinus bradycardia and delayed electrical conduction have been reported after BPA exposure, using in vivo and ex vivo models (Belcher et al 2015; Patel et al 2015; Posnack et al 2014; Valokola et al 2019). Patel et al observed conduction slowing in BPA-exposed animals subjected to catecholamine stress, although this effect was limited to females (Patel et al 2015).…”

Bisphenols and phthalates: Plastic chemical exposures can contribute to adverse cardiovascular health outcomes

“…BPA‐exposure can result in sinus bradycardia and delayed electrical conduction in rodent models, including prolonged P‐wave duration, PR interval and QRS duration (Belcher et al, 2015; B. B. Patel, Raad, Sebag, & Chalifour, 2015; Posnack et al, 2014; Valokola et al, 2019). Patel et al noted an exaggerated effect on electrical conduction in female BPA‐treated animals in response to catecholamine challenge (B.…”

“…Rasdi et al also reported an increase in maternal and fetal cardiac fibrosis following intrauterine BPA exposure (Rasdi et al, 2020). At higher BPA concentrations (50,000 μg kg −1 day −1 ), focal inflammation was observed in the cardiac tissue of pregnant mice, which coincided with slowing of cardiac electrical conduction and increased systolic and diastolic pressure relative to vehicle control (Valokola et al, 2019). The authors noted an attenuation of BPA‐induced effects when an anti‐inflammatory agent was administered.…”