Effect of bisphosphonates on orthodontic tooth movement in osteoporotic patients: A review

Arbelaez, Mary Luz; Garcia, Sergio Marino Viafara; López, Juan Pablo; Fernández-Ávila, Daniel G.; Munévar, Juan Carlos; Pauwels, Andres

doi:10.1016/j.ejwf.2018.03.001

Cited by 2 publications

(1 citation statement)

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“…The effects of bisphosphonates on orthodontic tooth movement in osteoporotic patients have already been explored in the literature. 38 However, the effects of the risedronate should be better elucidated. In accordance with the aforementioned studies, treatment time was enhanced because of the reduced mechanical-load tooth movement in the aforementioned case report.…”

Section: Discussionmentioning

confidence: 99%

Influence of risedronate on orthodontic tooth movement in rodents: a systematic review and case report

MIRANDA,

FERNANDES,

SANTOS

et al. 2023

Dental Press J. Orthod.

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Introduction: Bisphosphonates have an inhibitory impact on osteoclastic activity, reducing bone resorption. However, the influence of risedronate on tooth movement is not well-defined. Objective: This systematic review assessed the effect of risedronate intake on orthodontic tooth movement. A case report was also provided. Methods: Two independent reviewers searched six databases (PubMed, Web of Science, Ovid, Lilacs, Scopus, and Open Grey). The searches were carried out in April/2020, and an update was set in place in June/2023. Therefore, the searches considered a timeline from the databases’ inception date until June/2023, with no publication date and/or language restrictions. The clinical question focused on evaluating the orthodontic tooth movement and relapse movement (Outcome) in animals (Population) exposed to risedronate (Exposure), compared to control groups (Comparison). The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines were applied, and the protocol was registered in PROSPERO (CRD42020168581). The risk of bias was determined using the Systematic Review Centre for Laboratory Animal Experimentation protocol (SYRCLE). Results: Two studies in rats and one in guinea pigs were included in the systematic review. The studies reported a decrease in orthodontic tooth movement, a reduction in the relapse movement, and a reduced number of positive tartrate-resistant acid phosphatase (TRAP) cells, with a significantly reduced number of bone gaps after the administration of risedronate in rats. A case report illustrated the effects of risedronate administration in one patient. Conclusion: Based on the systematic review, risedronate seems to impair orthodontic tooth movement and relapse due to a decrease in bone resorption cells.

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Section: Discussionmentioning

confidence: 99%