Estrogen protects dental roots from orthodontic-induced inflammatory resorption

Amaro, Eduarda R.S.; Ortiz, Fernanda Ruffo; Dorneles, Leandro S.; Santos, Mauro Augusto dos; Barrioni, Breno Rocha; Miranda, Roberta M.; Garlet, Gustavo; Teixeira, Mauro Martins; Szawka, Raphael E.; Silva, Tarcı́lia Aparecida; Macari, Soraia

doi:10.1016/j.archoralbio.2020.104820

Cited by 17 publications

(21 citation statements)

References 53 publications

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“…After surgical removal of the ovaries, there is a lack of endogenous progesterone and estrogens, resulting in bone loss that initiates in two weeks post-surgery at the earliest, reaches 50% approximately after 4 to 8 weeks, and becomes stable within 12 weeks [ 65 ]. Ovariectomy results in osteopenia and osteoporosis and, subsequently, a higher rate of tooth movement [ 66 ], while estrogen administration reduces the speed of movement in osteoporotic rats [ 67 , 68 ], as it is closely related to the activity of osteoclasts [ 69 ]. The absence of estrogens has been associated with greater root resorption following orthodontic tooth movement as well [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

“…Ovariectomy results in osteopenia and osteoporosis and, subsequently, a higher rate of tooth movement [ 66 ], while estrogen administration reduces the speed of movement in osteoporotic rats [ 67 , 68 ], as it is closely related to the activity of osteoclasts [ 69 ]. The absence of estrogens has been associated with greater root resorption following orthodontic tooth movement as well [ 68 ].…”

Section: Discussionmentioning

confidence: 99%

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Does exogenous female sex hormone administration affect the rate of tooth movement and root resorption? A systematic review of animal studies

2021

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Background The long-term use of contraceptive methods that contain estrogens, progestogens or combinations of the above among women aged 15 to 49 years is extensive. Both estrogens and progestogens affect bone metabolism. Objective To systematically investigate and appraise the quality of the available evidence from animal studies regarding the impact of exogenous administration of female sex hormones on the rate of orthodontic tooth movement and root resorption. Search methods Search without restriction in seven databases (including grey literature) and hand searching were performed until May 2021. Selection criteria We looked for controlled animal studies investigating the effect from exogenous administration of formulations containing female sex hormones on the rate of orthodontic tooth movement and root resorption. Data collection and analysis After study retrieval and selection, relevant data was extracted, and the risk of bias was assessed using the SYRCLE’s Risk of Bias Tool. The quality of available evidence was assessed with the Grades of Recommendation, Assessment, Development, and Evaluation. Results Three studies were identified, all being at unclear risk of bias. Overall, administration of progesterone and the combinations of estradiol with norgestrel and desogestrel were shown to significantly decrease the rate of orthodontic tooth movement when given for longer periods (>3 weeks). Inconsistent information was detected for shorter periods of consumption. Estradiol, with desogestrel use, resulted in less root resorption. The quality of the available evidence was considered to be low. Conclusions Exogenous administration of female sex hormones may decelerate in the long term the rate of tooth movement and decrease orthodontically induced root resorption in animals. Until more information becomes available, an orthodontist should be able to identify a patient consuming such substances and understand the potential clinical implications and adverse effects that may arise. Registration PROSPERO: CRD42017078208; https://clinicaltrials.gov/.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Does exogenous female sex hormone administration affect the rate of tooth movement and root resorption? A systematic review of animal studies

2021

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“…In the context of orthodontic treatment, ovariectomy induced estrogen deficiency has been associated with an acceleratory effect on the rate of tooth movement [ 6 ], while its administration reduces the speed of movement in osteoporotic rats [ 41 , 42 ]. The rate of tooth movement is closely related to the activity of osteoclasts [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…In such cases however, in terms of mechanotherapy, patients might present increased needs for anchorage preparation or altered biomechanical systems because of the altered bone turnover [ 66 ]. Moreover, the absence of estradiol has been associated with greater root resorption following orthodontic tooth movement [ 42 ]. Although not directly studied in the material retrieved, one could also assume that retention procedures should be initiated when high levels of estradiol or progesterone are circulating.…”

Section: Discussionmentioning

confidence: 99%

Does the rate of orthodontic tooth movement change during the estrus cycle? A systematic review based on animal studies

et al. 2021

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Background As the fluctuation of sex hormone levels in menstruating women results in periodical effects in bone metabolism, understanding the implications for tooth movement could be of benefit to the orthodontist. This type of research presents practical and ethical problems in humans, but animal models could provide useful information. Our objective was to systematically investigate the available evidence on the question whether the rate of orthodontic tooth movement varies between the different stages of the estrus cycle in animals. Methods Unrestricted searches in 7 databases and manual searching of the reference lists in relevant studies were performed up to February 2021 (Medline [PubMed], CENTRAL [Cochrane Library; includes records from Embase, CINAHL, ClinicalTrials.gov, WHO's ICTRP, KoreaMed, Cochrane Review Groups’ Specialized Registers, and records identified by handsearching], Cochrane Database of Systematic Reviews [Cochrane Library], Scopus, Web of Knowledge [including Web of Science Core Collection, KCI Korean Journal Database, Russian Science Citation Index, SciELO Citation Index and Zoological Record], Arab World Research Source [EBSCO] and ProQuest Dissertation and Theses [ProQuest]). Our search focused on prospective controlled animal studies, whose samples included female subjects of any species that were quantitatively comparing the amount of tooth movement in the different stages of the estrus cycle. Following study retrieval and selection, relevant data was extracted, and the risk of bias was assessed using the SYRCLE’s Risk of Bias Tool. Results From the finally assessed records, 3 studies met the inclusion criteria. Two of the studies experimented on Wistar rats, whereas the other on cats. Tooth movement was induced by expansion or coil springs. The rate of orthodontic tooth movement was increased during the stages of the estrus cycle when oestrogen and/or progesterone levels were lower. The risk of bias in the retrieved studies was assessed to be unclear. Conclusion Hormonal changes during the estrus cycle may affect the rate of orthodontic tooth movement. Although these animal experiment results should be approached cautiously regarding their translational potential, it could be useful to consider the possible impact of these physiological changes in the clinical setting until more information becomes available. Registration: PROSPERO (CRD42021158069).

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“…Individual susceptibility, genetics, and systemic factors have been suggested as significant modulators of OIIRR [13]. Recent studies also investigated drugs and hormones as a potential influence on OIIRR [23][24][25][26][27], but to date, no research is available regarding cetirizine. Periodontal complications and subsequent alveolar bone loss are another possible side effect of orthodontic treatment, but can usually be controlled by proper oral hygiene [28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Effects of Histamine Receptor Antagonist Cetirizine on Orthodontic Tooth Movement

et al. 2020

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Many patients regularly take histamine receptor antagonists, such as cetirizine, to prevent allergic reactions, but these antiallergic drugs may have inadvertent effects on orthodontic treatment. In previous studies, histamine has been shown to modulate the sterile inflammatory reaction underlying orthodontic tooth movement. Pertinent effects of histamine antagonization via cetirizine during orthodontic treatment, however, have not been adequately investigated. We thus treated male Fischer344 rats either with tap water (control group) or cetirizine by daily oral gavage corresponding to the clinically used human dosage adjusted to the rat metabolism (0.87 mg/kg) or to a previously published high dosage of cetirizine (3 mg/kg). Experimental anterior movement of the first upper left molar was induced by insertion of a nickel-titanium (NiTi) coil spring (0.25 N) between the molar and the upper incisors. Cone-beam computed tomography (CBCT), micro-computed tomography (µCT) images, as well as histological hematoxylin-eosin (HE), and tartrate-resistant acid phosphatase (TRAP) stainings were used to assess the extent of tooth movement, cranial growth, periodontal bone loss, root resorptions, and osteoclast activity in the periodontal ligament. Both investigated cetirizine dosages had no impact on the weight gain of the animals and, thus, animal welfare. Neither the extent of tooth movement, nor cranial growth, nor root resorption, nor periodontal bone loss were significantly influenced by the cetirizine dosages investigated. We, thus, conclude that histamine receptor antagonist cetirizine can be used during orthodontic treatment to prevent allergic reactions without clinically relevant side effects on orthodontic tooth movement.

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Estrogen protects dental roots from orthodontic-induced inflammatory resorption

Cited by 17 publications

References 53 publications

Does exogenous female sex hormone administration affect the rate of tooth movement and root resorption? A systematic review of animal studies

Does exogenous female sex hormone administration affect the rate of tooth movement and root resorption? A systematic review of animal studies

Does the rate of orthodontic tooth movement change during the estrus cycle? A systematic review based on animal studies

Effects of Histamine Receptor Antagonist Cetirizine on Orthodontic Tooth Movement

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