Effects of Histamine Receptor Antagonist Cetirizine on Orthodontic Tooth Movement

Abstract

Many patients regularly take histamine receptor antagonists, such as cetirizine, to prevent allergic reactions, but these antiallergic drugs may have inadvertent effects on orthodontic treatment. In previous studies, histamine has been shown to modulate the sterile inflammatory reaction underlying orthodontic tooth movement. Pertinent effects of histamine antagonization via cetirizine during orthodontic treatment, however, have not been adequately investigated. We thus treated male Fischer344 rats either with tap water (control group) or cetirizine by daily oral gavage corresponding to the clinically used human dosage adjusted to the rat metabolism (0.87 mg/kg) or to a previously published high dosage of cetirizine (3 mg/kg). Experimental anterior movement of the first upper left molar was induced by insertion of a nickel-titanium (NiTi) coil spring (0.25 N) between the molar and the upper incisors. Cone-beam computed tomography (CBCT), micro-computed tomography (µCT) images, as well as histological hematoxylin-eosin (HE), and tartrate-resistant acid phosphatase (TRAP) stainings were used to assess the extent of tooth movement, cranial growth, periodontal bone loss, root resorptions, and osteoclast activity in the periodontal ligament. Both investigated cetirizine dosages had no impact on the weight gain of the animals and, thus, animal welfare. Neither the extent of tooth movement, nor cranial growth, nor root resorption, nor periodontal bone loss were significantly influenced by the cetirizine dosages investigated. We, thus, conclude that histamine receptor antagonist cetirizine can be used during orthodontic treatment to prevent allergic reactions without clinically relevant side effects on orthodontic tooth movement.

Real-Time Monitoring and Quantitative Evaluation of Resin In-Filtrant Repairing Enamel White Spot Lesions Based on Optical Coherence Tomography

“…The extracted right incisors of Rabbits #3, #4, #5, #6 and #7 were immersed in an EDTA decalcifying solution (Sangon Biotech, Shanghai, China) [36]. After rinsing for 5 min with running water, the samples were dehydrated and embedded in paraffin (Xiya Reagent, Linyi, Shandong, China).…”

Under pressure—mechanisms and risk factors for orthodontically induced inflammatory root resorption: a systematic review

“…All results showed that force-tested groups have a significantly higher risk of OIIRR than the no-force control groups ( 92 , 93 , 94 , 95 , 91 , 96 , 97 , 98 , 99 , 100 , 10 , 2 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 ). Only one study reported no significant difference in OIIRR between the intermittent force and control Groups ( 103 ).…”

“…Only one study reported no significant difference in OIIRR between the intermittent force and control Groups ( 103 ). Eight studies had data for the secondary outcomes; histological and molecular findings ( 91 , 100 , 10 , 101 , 2 , 102 , 104 , 106 ). The summaries of the included studies are listed in Supplementary Table 9 .…”

“…Twenty-eight articles were included for data extraction, 1 on mice ( 91 ) and 27 on three different types of rats (Wister, Sprague-Dawley, and Fischer-344) ( 92 , 93 , 113 , 114 , 115 , 95 , 116 , 117 , 97 , 118 , 10 , 119 , 2 , 120 , 102 , 121 , 122 , 123 , 124 , 105 , 125 , 106 , 126 , 128 , 108 , 109 , 127 ). All articles were published between 2003 and 2021.…”

Models for Oral Biology Research

“…Sperl et al [9] hypothesized that many patients, to prevent allergic reactions, regularly use histamine receptor antagonists, such as cetirizine. However, these may have adverse effects on orthodontic treatment.…”