EFFECT OF BLACK GRAPE EXTRACT ON CD4+ and CD8+ EXPRESSION IN MICE INFECTED WITH Salmonella typhimurium

Abstract

Salmonelosis is a disease caused by the Salmonella sp. that causes a decrease in CD4+ expression. Black grape can boost the immune system through CD4+/CD8+ proliferation. The purpose of this study was to evaluate the activity of black grape extract to CD4+ and CD8+ expression in mice infected with Salmonella typhimurium. Research method is extract of black grapes, Salmonella typhimurium 108 infection, bacterial evaluation, extract therapy, flowcytometery examination, and 95% Anova test. The results of Anova test showed that the expression of CD4+ and CD8+ is not different. Biologically, an increase in CD4+ and CD8+ expression at doses of 100 mg/KgBB. A decrease in CD4+ and CD8+ expression at doses of 200 mg/KgBB and 400 mg/KgBB. Conclusion, biologically, black grape extract can increase the expression of CD4+ and CD8+ at low doses, as well as may decrease the expression of CD4+ and CD8+ at moderate to high doses.

Immunomodulator Effect of Cnidoscolus aconitifolius Leaves Extract on CD4+ and CD8+ Expression in Salmonella typhimurium infected mice

“…However, in Salmonella typhimurium bacterial infection, Salmonella typhimurium bacteria can inhibit MHC II presentation to CD4 + T cells (Alix et al, 2022) thus, CD4 + T lymphocyte cells are inactive and decrease CD4 + T cell expression when compared to normal (Figure 1 dan Figure 2). This event will lead to excessive systemic infection played by Salmonella typhimurium bacteria (Destiawan et al, 2023).…”

“…Therapy was started after the mice showed infection. Therapy is administered orally once a day for 7 days (Destiawan et al, 2023).…”