Effect of Blood Transfusion in an Experimental Sarcoma Model

Lin, Ho Sheng; Samy, Ravi N.; Lum, Joanne; Dorie, Mary J.; Terris, David J.

doi:10.1001/archotol.128.3.308

Cited by 6 publications

(7 citation statements)

References 19 publications

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“…Several studies indicated that immunosuppressive effect is mediated by the leukocytes presence in allogeneic blood (Kirkley, 1999;Chu, 1999). The infusion of incompatible major histocompatibility complex antigens between donor and recipient may be responsible for this deleterious effect (Lin et al, 2002). Perioperative decrease in the interleukin-2 (IL-2) and natural killer (NK) cells activity suggested that allogeneic blood transfusion compromises the immune response (Bar-Yosef et al, 2001;Yan et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Effect of perioperative autologous versus allogeneic blood transfusion on the immune system in gastric cancer patients

Chen

Zhang

Gong

et al. 2007

J. Zhejiang Univ. - Sci. B

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Abstract:Background: Allogeneic blood transfusion-induced immunomodulation (TRIM) and its adverse effect on the prognosis of patients treated surgically for cancer remain complex and controversial. However, the potential risk associated with allogeneic blood transfusion has heightened interest in the use of autologous blood transfusion. In the present study, the serum concentrations of neopterin, interferon-gamma (IFN-γ), T lymphocyte subsets (CD3 + ratio had significantly decreased after operation, but decreased more significantly in group H (receiving allogeneic blood transfusion) than those in group A (receiving autologous whole blood transfusion) (P<0.05). On the 5th postoperative day, serum neopterin, IFN-γ, CD3 + , CD4+ T-cells, and CD4 + /CD8 + ratio returned to the baseline values in group A. In contrast, the above remain decreasing in group H, where there were no significant relations between serum neopterin and IFN-γ. Conclusion: Perioperative surgical trauma and stress have an immunosuppressive impact on gastric cancer patients. Allogeneic blood transfusion exacerbates the impaired immune response. Autologous blood transfusion might be significantly beneficial for immune-compromised patients in the perioperative period, clearly showing its superiority over allogeneic blood transfusion.

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Section: Introductionmentioning

confidence: 99%

Effect of perioperative autologous versus allogeneic blood transfusion on the immune system in gastric cancer patients

Chen

Zhang

Gong

et al. 2007

J. Zhejiang Univ. - Sci. B

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“…*Significant at 0.05, **significant at 0.01 Fig. 3 Kaplan-Meier survival curves for control and blood transfusion groups et al [3] observed that, in animal models, tumor size increase in allogeneic blood transfusion could be higher than syngeneic blood transfusion. However, syngeneic and autologous blood transfusion did not have different effects on tumor growth.…”

Section: Discussionmentioning

confidence: 96%

“…It could be allogeneic (obtained from a subject for injection to another of the same species) or autologous (obtained from a subject for injection to himself/itself) [1,2]. In laboratory animals, syngeneic blood transfusion (from inbred laboratory animals to another inbred animals of the same species) is also performed [3]. Since many years ago, blood transfusion has found an important place in medicine.…”

Section: Introductionmentioning

confidence: 99%

“…Increased prevalence of cancers and sudden relapse or growth of tumors are some consequences associated with TRIM. However, studies on immunomodulatory effects of transfusion of blood products on the growth and metastasis of tumors are not frequent [2,3,8,12,14,[16][17][18][19]. Therefore, the current study aimed to evaluate effects of allogeneic, syngeneic, fresh and storage blood transfusion on the growth and metastasis of tumors and survival in fibrosarcoma bearing BALB/c mice.…”

Section: Introductionmentioning

confidence: 99%

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Immunomodulatory Effects of Blood Transfusion on Tumor Size, Metastasis, and Survival in Experimental Fibrosarcoma

Abdolmohammadi

Mahmoudi

Jafari‐Koshki

et al. 2018

Indian J Hematol Blood Transfus

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In spite of efforts, blood transfusion is still accompanied with adverse effects such as transfusion-related immunomodulation (TRIM). The current study aimed to evaluate the effects of allogeneic, syngeneic, fresh and storage blood transfusion on the growth and metastasis of tumors and survival in fibrosarcoma bearing BALB/c mice. Twenty-five BALB/c mice were grouped into five groups of equal size. All groups were injected 1.2 9 10 6 WEHI-164 cells subcutaneously to induce fibrosarcoma tumor. After expansion of the tumor, in four groups (except for the control group), hemorrhage-induced anemia was developed. Twenty-four hours later, blood deficit was replaced by fresh allogeneic, storage allogeneic, fresh syngeneic and storage syngeneic blood transfusion, respectively. After a blood transfusion, for 13 days, the tumor size and survival of the mice were evaluated. In the day 20, the mice were sacrificed and their spleen tissues were evaluated for TRIM induced metastasis. Tumor size increase in the groups that received allogeneic (fresh and storage) and storage syngeneic blood transfusion was significantly higher than the control group (P value \ 0.05). However, no significant difference was present in survival between the experiment groups and the control group. There was no metastasis in none of groups at the end of the study. Allogeneic and storage blood transfusion could have immunomodulatory effects such as increased tumor size. However, it seems that fresh and syngeneic blood transfusion have no effects on tumor growth in fibrosarcoma bearing mice. Further evidence may prove that more attention is warranted in blood transfusion into cancer cases.

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“…They tried to identify whether red cells, leukocytes or soluble factors from RBC units display cancer-promoting effects and found that aged erythrocytes, rather than leukocytes or soluble factors, were accountable for the effects in a storage time- and cell volume-dependent manner. Lin and colleagues compared the effects of allogeneic vs. syngeneic vs. autologous RBC transfusions in a murine model of a solid sarcoma [ 10 ]. They found that allogeneic blood transfusion was associated with an increased rate of tumor growth and postulated that this was mediated by major histocompatibility complex incompatible antigens, incurring immunomodulatory effects in the transfusion recipients.…”

Section: Introductionmentioning

confidence: 99%

Red Blood Cell-Derived Microparticles Exert No Cancer Promoting Effects on Colorectal Cancer Cells In Vitro

Fischer

Thies

Awad

et al. 2022

IJMS

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The biomedical consequences of allogeneic blood transfusions and the possible pathomechanisms of transfusion-related morbidity and mortality are still not entirely understood. In retrospective studies, allogeneic transfusion was associated with increased rates of cancer recurrence, metastasis and death in patients with colorectal cancer. However, correlation does not imply causation. The purpose of this study was to elucidate this empirical observation further in order to address insecurity among patients and clinicians. We focused on the in vitro effect of microparticles derived from red blood cell units (RMPs). We incubated different colon carcinoma cells with RMPs and analyzed their effects on growth, invasion, migration and tumor marker expression. Furthermore, effects on Wnt, Akt and ERK signaling were explored. Our results show RMPs do not seem to affect functional and phenotypic characteristics of different colon carcinoma cells and did not induce or inhibit Wnt, Akt or ERK signaling, albeit in cell culture models lacking tumor microenvironment. Allogeneic blood transfusions are associated with poor prognosis, but RMPs do not seem to convey tumor-enhancing effects. Most likely, the circumstances that necessitate the transfusion, such as preoperative anemia, tumor stage, perioperative blood loss and extension of surgery, take center stage.

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Effect of Blood Transfusion in an Experimental Sarcoma Model

Cited by 6 publications

References 19 publications

Effect of perioperative autologous versus allogeneic blood transfusion on the immune system in gastric cancer patients

Effect of perioperative autologous versus allogeneic blood transfusion on the immune system in gastric cancer patients

Immunomodulatory Effects of Blood Transfusion on Tumor Size, Metastasis, and Survival in Experimental Fibrosarcoma

Red Blood Cell-Derived Microparticles Exert No Cancer Promoting Effects on Colorectal Cancer Cells In Vitro

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